back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - TNF receptor-associated factor 6
PR:000002292 - http://purl.obolibrary.org/obo/PR_000002292
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002292   
  PRO nameTNF receptor-associated factor 6 
  Synonyms
PRO-Short-label: EXACT:TRAF6
Gene-based: RELATED:RNF85
Other: EXACT:E3 ubiquitin-protein ligase TRAF6 | interleukin-1 signal transducer | RING finger protein 85 | RING-type E3 ubiquitin transferase TRAF6
  Definition"A TNF receptor-associated factor that is a translation product of the human TRAF6 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000002191 TNF receptor-associated factor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence2                                                  Organism-Sequence 3                                        
         Modification3                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000002292
TNF receptor-associated factor 6
TRAF6
"A TNF receptor-associated factor that is a translation product of the human TRAF6 gene or a 1:1 ortholog thereof." [PRO:WCB]

organism-gene


PR:B5DF45
TNF receptor-associated factor 6 (rat)
rTRAF6
"A TNF receptor-associated factor 6 that is encoded in the genome of rat." [OMA:B5DF45, PRO:DNx]

organism-gene


PR:P70196
TNF receptor-associated factor 6 (mouse)
mTRAF6
"A TNF receptor-associated factor 6 that is encoded in the genome of mouse." [OMA:P70196, PRO:CNA]

Yes
organism-sequence


PR:P70196-1
TNF receptor-associated factor 6 isoform 1 (mouse)
mTRAF6/iso:1
"A TNF receptor-associated factor 6 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

organism-modification


PR:000035712
TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 (mouse)
mTRAF6/iso:1/K63polyUbiq:1
"A TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 in mouse. UniProtKB:P70196-1, Lys-124, PR:000044772." [PMID:17135271, PRO:HJD, TLR:AMM]

organism-sequence


PR:P70196-2
TNF receptor-associated factor 6 isoform 2 (mouse)
mTRAF6/iso:2
"A TNF receptor-associated factor 6 isoform 2 that is encoded in the genome of mouse." [PRO:JAN]

organism-gene


PR:Q6IWL4
TNF receptor-associated factor 6 (zebrafish)
z-TRAF6
"A TNF receptor-associated factor 6 that is encoded in the genome of zebrafish." [OMA:Q6IWL4, PRO:DNx]

organism-gene


PR:Q9Y4K3
TNF receptor-associated factor 6 (human)
hTRAF6
"A TNF receptor-associated factor 6 that is encoded in the genome of human." [PRO:CNx, UniProtKB:Q9Y4K3]

Yes
organism-sequence


PR:Q9Y4K3-1
TNF receptor-associated factor 6 isoform 1 (human)
hTRAF6/iso:1
"A TNF receptor-associated factor 6 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-modification


PR:000035714
TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human)
hTRAF6/K63polyUbiq:1
"A TNF receptor-associated factor 6 K63-polyubiquitinated 1 in human. UniProtKB:Q9Y4K3, Lys-124, PR:000044772." [PRO:DAN, UniProtKB:Q9Y4K3]
Yes
Yes
organism-modification


PR:000064696
TNF receptor-associated factor 6 ubiquitinated form (human)
hTRAF6/UbiqLys+
"A TNF receptor-associated factor 6 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q9Y4K3, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782845, Reactome:R-HSA-6783233]

organism-modification


PR:000066371
TNF receptor-associated factor 6 cysteinylated 1 (human)
hTRAF6/Cyst:1
"A TNF receptor-associated factor 6 (human) that has been cysteinylated on the residue at the position equivalent to Cys-390 of the amino acid sequence represented by UniProtKB:Q9Y4K3. UniProtKB:Q9Y4K3, Cys-390, MOD:00765." [IEDB_epitope:1004109, PRO:DNx]

sequence


PR:000002381
TNF receptor-associated factor 6 isoform 1
TRAF6/iso:1
"A TNF receptor-associated factor 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4K3-1 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:P70196-1
TNF receptor-associated factor 6 isoform 1 (mouse)
mTRAF6/iso:1
"A TNF receptor-associated factor 6 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]

organism-modification


PR:000035712
TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 (mouse)
mTRAF6/iso:1/K63polyUbiq:1
"A TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 in mouse. UniProtKB:P70196-1, Lys-124, PR:000044772." [PMID:17135271, PRO:HJD, TLR:AMM]

organism-sequence


PR:Q9Y4K3-1
TNF receptor-associated factor 6 isoform 1 (human)
hTRAF6/iso:1
"A TNF receptor-associated factor 6 isoform 1 that is encoded in the genome of human." [PRO:JAN]

modification


PR:000003138
TNF receptor-associated factor 6 isoform 1 ubiquitinated form
TRAF6/iso:1/UbiqLys+
"A TNF receptor-associated factor 6 isoform 1 that includes at least one ubiquitinated lysine." [PRO:CNA]

modification


PR:000003139
TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1
TRAF6/iso:1/K63polyUbiq:1
"A TNF receptor-associated factor 6 isoform 1 ubiquitinated form that is a major product of site-specific Lys-63-linked auto-ubiquitination. The ubiquitinated Lys residue is located downstream the RING domain. Example: UniProtKB:P70196-1, Lys-124, PR:000044772." [PMID:17135271, PRO:HJD, TLR:AMM]

organism-modification


PR:000035712
TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 (mouse)
mTRAF6/iso:1/K63polyUbiq:1
"A TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 in mouse. UniProtKB:P70196-1, Lys-124, PR:000044772." [PMID:17135271, PRO:HJD, TLR:AMM]

sequence


PR:000002382
TNF receptor-associated factor 6 isoform 2
TRAF6/iso:2
"A TNF receptor-associated factor 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70196-2 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:P70196-2
TNF receptor-associated factor 6 isoform 2 (mouse)
mTRAF6/iso:2
"A TNF receptor-associated factor 6 isoform 2 that is encoded in the genome of mouse." [PRO:JAN]

modification


PR:000035713
TNF receptor-associated factor 6 K63-polyubiquitinated 1
TRAF6/K63polyUbiq:1
"A TNF receptor-associated factor 6 that is a major product of site-specific Lys-63-linked auto-ubiquitination. Example: UniProtKB:Q9Y4K3, Lys-124, PR:000044772." [PRO:CNx, PRO:DAN]

organism-modification


PR:000035714
TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human)
hTRAF6/K63polyUbiq:1
"A TNF receptor-associated factor 6 K63-polyubiquitinated 1 in human. UniProtKB:Q9Y4K3, Lys-124, PR:000044772." [PRO:DAN, UniProtKB:Q9Y4K3]
Yes
Yes
Back to top
TRAF6 forms found in complexes   

TRAF6 Component
 Complexes
PR:000035714 hTRAF6/K63polyUbiq:1 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:P70196 mTRAF6 PR:000035710 traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036111 K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000036114 IkappaB kinase:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000036117 pIKBK:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000037471 traf6:ticam1:activated TLR3 complex (mouse)
PR:Q9Y4K3 hTRAF6 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000037344 traf6:ticam1:activated TLR3 complex (human)
Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035714 hTRAF6/K63polyUbiq:1
UniProtKB:Q9Y4K3, Lys-124, PR:000044772		 acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894