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Protein Ontology report - tyrosine-protein kinase Lck
PR:000002998 - http://purl.obolibrary.org/obo/PR_000002998
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002998   
  PRO nametyrosine-protein kinase Lck 
  Synonyms
PRO-Short-label: EXACT:LCK
Gene-based: RELATED:Lsk-t
Other: EXACT:leukocyte C-terminal Src kinase | LSK | lymphocyte cell-specific protein-tyrosine kinase | p56-LCK | proto-oncogene Lck | proto-oncogene tyrosine-protein kinase lck | T cell-specific protein-tyrosine kinase
  Definition"A proto-oncogene SRC-like tyrosine-protein kinase that is a translation product of the human LCK gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000002997 proto-oncogene SRC-like tyrosine-protein kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification3                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2053
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000002998 tyrosine-protein kinase Lck
LCK

organism-gene


PR:P06239 tyrosine-protein kinase Lck (human)
hLCK

Yes
organism-sequence


PR:P06239-1 tyrosine-protein kinase Lck isoform Long (human)
hLCK/iso:Long

organism-modification


PR:000036619 tyrosine-protein kinase Lck isoform 1 phosphorylated 1 (human)
hLCK/iso:1/Phos:1
Yes
organism-modification


PR:000036622 tyrosine-protein kinase Lck isoform 1 phosphorylated 2 (human)
hLCK/iso:1/Phos:2
Yes
organism-sequence


PR:P06239-2 tyrosine-protein kinase Lck isoform Short (human)
hLCK/iso:Short

organism-sequence


PR:P06239-3 tyrosine-protein kinase Lck isoform h3 (human)
hLCK/iso:h3

organism-modification


PR:000048171 tyrosine-protein kinase Lck phosphorylated 2 (human)
hLCK/Phos:2

organism-modification


PR:000048172 tyrosine-protein kinase Lck phosphorylated 3 (human)
hLCK/Phos:3

organism-gene


PR:P06240 proto-oncogene tyrosine-protein kinase LCK (mouse)
mLCK

organism-sequence


PR:P06240-1 proto-oncogene tyrosine-protein kinase LCK isoform 1 (mouse)
mLCK/iso:1

organism-modification


PR:000045642 proto-oncogene tyrosine-protein kinase LCK phosphorylated 1 (mouse)
mLCK/Phos:1

organism-modification


PR:000049824 proto-oncogene tyrosine-protein kinase LCK phosphorylated 2 (mouse)
mLCK/Phos:2

organism-modification


PR:000049825 proto-oncogene tyrosine-protein kinase LCK phosphorylated 3 (mouse)
mLCK/Phos:3

organism-gene


PR:Q01621 proto-oncogene tyrosine-protein kinase LCK (rat)
rLCK

sequence


PR:000002999 tyrosine-protein kinase Lck isoform 1
LCK/iso:1

organism-sequence


PR:P06239-1 tyrosine-protein kinase Lck isoform Long (human)
hLCK/iso:Long

organism-modification


PR:000036619 tyrosine-protein kinase Lck isoform 1 phosphorylated 1 (human)
hLCK/iso:1/Phos:1
Yes
organism-modification


PR:000036622 tyrosine-protein kinase Lck isoform 1 phosphorylated 2 (human)
hLCK/iso:1/Phos:2
Yes
organism-sequence


PR:P06240-1 proto-oncogene tyrosine-protein kinase LCK isoform 1 (mouse)
mLCK/iso:1

modification


PR:000003000 tyrosine-protein kinase Lck isoform 1 phosphorylated form
LCK/iso:1/PhosRes+

modification


PR:000003001 tyrosine-protein kinase Lck isoform 1 phosphorylated 1
LCK/iso:1/Phos:1

organism-modification


PR:000036619 tyrosine-protein kinase Lck isoform 1 phosphorylated 1 (human)
hLCK/iso:1/Phos:1
Yes
modification


PR:000003034 tyrosine-protein kinase Lck isoform 1 phosphorylated 2
LCK/iso:1/Phos:2

organism-modification


PR:000036622 tyrosine-protein kinase Lck isoform 1 phosphorylated 2 (human)
hLCK/iso:1/Phos:2
Yes
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LCK forms found in complexes   

LCK Component
 Complexes
PR:P06239 hLCK PR:000028449 CD4:Lck complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036619 hLCK/iso:1/Phos:1
UniProtKB:P06239-1, Tyr-394/Tyr-505, MOD:00048		 enablesdecreased GO:0016301 kinase activity relative to PR:000036622 hLCK/iso:1/Phos:2 PMID:9043947
PR:000036622 hLCK/iso:1/Phos:2
UniProtKB:P06239-1, Tyr-394, MOD:00048		 enablesGO:0016301 kinase activity PMID:9043947
GO:0044877 protein-containing complex binding PMID:9043947