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Protein Ontology report - cyclin-dependent kinase inhibitor 1B isoform 1
PR:000003091 - http://purl.obolibrary.org/obo/PR_000003091
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003091   
  PRO namecyclin-dependent kinase inhibitor 1B isoform 1 
  Synonyms
PRO-Short-label: EXACT:CDKN1B/iso:1
  Definition"A cyclin-dependent kinase inhibitor 1B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46527-1 or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorysequence 
  ParentPR:000003090 cyclin-dependent kinase inhibitor 1B
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification5                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000003091 cyclin-dependent kinase inhibitor 1B isoform 1
CDKN1B/iso:1

organism-sequence


PR:P46414-1 cyclin-dependent kinase inhibitor 1B isoform 1 (mouse)
mCDKN1B/iso:1

organism-sequence


PR:P46527-1 cyclin-dependent kinase inhibitor 1B isoform 1 (human)
hCDKN1B/iso:1

organism-modification


PR:000025750 cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2 (human)
hCDKN1B/iso:1/Phos:2
Yes
organism-modification


PR:000025752 cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 3 (human)
hCDKN1B/iso:1/Phos:3

organism-modification


PR:000036634 cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 1 (human)
hCDKN1B/iso:1/Phos:1
Yes
organism-modification


PR:000045370 cyclin-dependent kinase inhibitor 1B isoform 1 unphosphorylated 2 (human)
hCDKN1B/iso:1/UnPhos:2
Yes
modification


PR:000003092 cyclin-dependent kinase inhibitor 1B isoform 1 unmodified form
CDKN1B/iso:1/UnMod

modification


PR:000003093 cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated form
CDKN1B/iso:1/PhosRes+

modification


PR:000003094 cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 1
CDKN1B/iso:1/Phos:1

organism-modification


PR:000036634 cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 1 (human)
hCDKN1B/iso:1/Phos:1
Yes
modification


PR:000025749 cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2
CDKN1B/iso:1/Phos:2

organism-modification


PR:000025750 cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2 (human)
hCDKN1B/iso:1/Phos:2
Yes
modification


PR:000025751 cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 3
CDKN1B/iso:1/Phos:3

organism-modification


PR:000025752 cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 3 (human)
hCDKN1B/iso:1/Phos:3

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025750 hCDKN1B/iso:1/Phos:2
UniProtKB:P46527-1, Tyr-88, MOD:00048		 acts_upstream_of_or_withinGO:0051318 G1 phase PMID:17254966
enablesdecreased GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity relative to PR:000045370 hCDKN1B/iso:1/UnPhos:2 PMID:17254966
GO:0005515 protein binding with PR:P24385 B-cell lymphoma 1 protein (human) PMID:17254966
GO:0005515 protein binding with PR:P24864 CCNE PMID:17254966
GO:0005515 protein binding PMID:17254966
GO:0044877 protein-containing complex binding PMID:17254966
PR:000036634 hCDKN1B/iso:1/Phos:1
UniProtKB:P46527-1, Thr-157, MOD:00047		 acts_upstream_of_or_withinGO:0008284 positive regulation of cell population proliferation PMID:12244301
enablesdecreased GO:0005515 protein binding with PR:P31946 hYWHAB PMID:15057270
decreased GO:0005515 protein binding with PR:P61981 hYWHAG PMID:15057270
decreased GO:0005515 protein binding with PR:P62258 14-3-3E (human) PMID:15057270
decreased GO:0005515 protein binding with PR:P52294 hKPNA1 PMID:15057270
located_inGO:0005737 cytoplasm PMID:15057270
GO:0005829 cytosol PMID:12244301
PR:000045370 hCDKN1B/iso:1/UnPhos:2
UniProtKB:P46527-1, Tyr-88, PR:000026291		 acts_upstream_of_or_withinGO:0008285 negative regulation of cell population proliferation PMID:12244301
GO:0051318 G1 phase PMID:17254966
enablesGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity PMID:17254966
GO:0005515 protein binding PMID:12244301
GO:0044877 protein-containing complex binding PMID:17254966
located_inGO:0005634 nucleus PMID:12244301