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Protein Ontology report - cyclin-dependent kinase inhibitor 1B isoform 1 (human)
PR:P46527-1 - http://purl.obolibrary.org/obo/PR_P46527-1
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P46527-1   
  PRO namecyclin-dependent kinase inhibitor 1B isoform 1 (human) 
  Synonyms
PRO-Short-label: EXACT:hCDKN1B/iso:1
  Definition"A cyclin-dependent kinase inhibitor 1B isoform 1 that is encoded in the genome of human." [PRO:CNA] 
  PRO Categoryorganism-sequence 
  ParentPR:000003091 cyclin-dependent kinase inhibitor 1B isoform 1
PR:P46527 cyclin-dependent kinase inhibitor 1B (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P46527-1
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
organism-sequence


PR:P46527-1 cyclin-dependent kinase inhibitor 1B isoform 1 (human)
hCDKN1B/iso:1

organism-modification


PR:000025750 cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2 (human)
hCDKN1B/iso:1/Phos:2
Yes
organism-modification


PR:000025752 cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 3 (human)
hCDKN1B/iso:1/Phos:3

organism-modification


PR:000036634 cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 1 (human)
hCDKN1B/iso:1/Phos:1
Yes
organism-modification


PR:000045370 cyclin-dependent kinase inhibitor 1B isoform 1 unphosphorylated 2 (human)
hCDKN1B/iso:1/UnPhos:2
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025750 hCDKN1B/iso:1/Phos:2
UniProtKB:P46527-1, Tyr-88, MOD:00048
"A cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2 in human. Phosphorylation at this site promotes subsequent Cdk2-mediated phosphorylation at Thr-187. UniProtKB:P46527-1, Tyr-88, MOD:00048." [PMID:17254966, PRO:JAN]		 acts_upstream_of_or_withinGO:0051318 G1 phase PMID:17254966
enablesdecreased GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity relative to PR:000045370 hCDKN1B/iso:1/UnPhos:2 PMID:17254966
GO:0005515 protein binding with PR:P24385 B-cell lymphoma 1 protein (human) PMID:17254966
GO:0005515 protein binding with PR:P24864 CCNE PMID:17254966
GO:0005515 protein binding PMID:17254966
GO:0044877 protein-containing complex binding PMID:17254966
PR:000036634 hCDKN1B/iso:1/Phos:1
UniProtKB:P46527-1, Thr-157, MOD:00047
"A cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 1 in human. UniProtKB:P46527-1, Thr-157, MOD:00047." [PMID:12244301, PMID:15057270, PRO:JAN]		 acts_upstream_of_or_withinGO:0008284 positive regulation of cell population proliferation PMID:12244301
enablesdecreased GO:0005515 protein binding with PR:P31946 hYWHAB PMID:15057270
decreased GO:0005515 protein binding with PR:P61981 hYWHAG PMID:15057270
decreased GO:0005515 protein binding with PR:P62258 14-3-3E (human) PMID:15057270
decreased GO:0005515 protein binding with PR:P52294 hKPNA1 PMID:15057270
located_inGO:0005737 cytoplasm PMID:15057270
GO:0005829 cytosol PMID:12244301
PR:000045370 hCDKN1B/iso:1/UnPhos:2
UniProtKB:P46527-1, Tyr-88, PR:000026291
"A cyclin-dependent kinase inhibitor 1B isoform 1 (human) that lacks phosphorylation at Tyr-88. UniProtKB:P46527-1, Tyr-88, PR:000026291." [PRO:CNA]		 acts_upstream_of_or_withinGO:0008285 negative regulation of cell population proliferation PMID:12244301
GO:0051318 G1 phase PMID:17254966
enablesGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity PMID:17254966
GO:0005515 protein binding PMID:12244301
GO:0044877 protein-containing complex binding PMID:17254966
located_inGO:0005634 nucleus PMID:12244301