back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - IRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex
PR:000028699 - http://purl.obolibrary.org/obo/PR_000028699
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000028699   
  PRO nameIRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex 
  Synonyms
Reactome-displayName: RELATED:activated TLR4:TRAM:TRIF:p-TBK1/p-IKKE:IRF3/IRF7
  Definition"A protein-containing complex that is composed of activated Toll-like receptor 4 (TLR4), Ticam2, Ticam1, a phosphorylated kinase tbk1 or IKK epsilon and the non-phosphorylated form of IRF3 or IRF7. IRF3 and IRF7 are recruited via phosphorylated tbk1 and IKK epsilon." [] 
  CommentRequested by=TLR. 
  PRO Categorycomplex 
  ParentG0032991 protein-containing complex
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Complex5                                                  Organism-Complex 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
complex


PR:000028699 IRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex
hTBK1/Phos:1

complex


PR:000036029 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
BTBD7/iso:3

organism-complex


PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
BTBD7/iso:3
Yes
complex


PR:000036033 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
hTRAF3/K63polyUbiq+

organism-complex


PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
hTRAF3/K63polyUbiq+
Yes
complex


PR:000036035 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
hTRAF3/K63polyUbiq+

organism-complex


PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
hTRAF3/K63polyUbiq+
Yes
complex


PR:000036037 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
hTRAF3/K63polyUbiq+

organism-complex


PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
hTRAF3/K63polyUbiq+
Yes
Back to top
Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathwayPR:000036030 BTBD7/iso:3 Reactome:REACT_6809
PR:000036034 hTRAF3/K63polyUbiq+ Reactome:REACT_6809
PR:000036036 hTRAF3/K63polyUbiq+ Reactome:REACT_6809
PR:000036038 hTRAF3/K63polyUbiq+ Reactome:REACT_6809

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004674 protein serine/threonine kinase activityPR:000036030 BTBD7/iso:3 Reactome:REACT_27000
PR:000036034 hTRAF3/K63polyUbiq+ Reactome:REACT_27000
PR:000036036 hTRAF3/K63polyUbiq+ Reactome:REACT_27000
PR:000036038 hTRAF3/K63polyUbiq+ Reactome:REACT_27000

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0010008 endosome membranePR:000036030 BTBD7/iso:3 Reactome:REACT_27000
PR:000036034 hTRAF3/K63polyUbiq+ Reactome:REACT_27000
PR:000036036 hTRAF3/K63polyUbiq+ Reactome:REACT_27000
PR:000036038 hTRAF3/K63polyUbiq+ Reactome:REACT_27000