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Protein Ontology report - CD14 molecule cleaved 2

PR:000036848 - http://purl.obolibrary.org/obo/PR_000036848

Protein Forms

Complex

Annotations

Ontology Information

Show OBO stanza

PAF

PRO ID

PR:000036848

PRO name

CD14 molecule cleaved 2

Synonyms

PRO-Short-label:

EXACT:

CD14/Clv:2

Definition

"A CD14 molecule, signal peptide removed form that lacks the propeptide. Example: UniProtKB:P08571, 20-345." [PRO:DAN]

PRO Category

modification

Parent

PR:000018574 CD14 molecule, signal peptide removed form

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Modification	3	Organism-Modification	6

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

modification

PR:000036848 CD14 molecule cleaved 2

CD14/Clv:2

Yes

modification

PR:000002147 CD14 molecule cleaved 2 soluble form

CD14/Clv:2/soluble

Yes

organism-modification

PR:000029986 CD14 molecule cleaved 2 soluble form (mouse)

mCD14/Clv:2/soluble

organism-modification

PR:000035703 CD14 molecule cleaved 2 soluble form (human)

hCD14/Clv:2/soluble

Yes

modification

PR:000002149 CD14 molecule cleaved 2 GPI-anchored form

CD14/Clv:2/anchored

Yes

organism-modification

PR:000035702 CD14 molecule cleaved 2 GPI-anchored form (human)

hCD14/Clv:2/anchored

Yes

organism-modification

PR:000037470 CD14 molecule cleaved 2 GPI-anchored form (mouse)

mCD14/Clv:2/anchored

Yes

organism-modification

PR:000036946 CD14 molecule cleaved 2 (mouse)

mCD14/Clv:2

organism-modification

PR:000029986 CD14 molecule cleaved 2 soluble form (mouse)

mCD14/Clv:2/soluble

organism-modification

PR:000037470 CD14 molecule cleaved 2 GPI-anchored form (mouse)

mCD14/Clv:2/anchored

organism-modification

PR:000037480 CD14 molecule cleaved 2 (human)

hCD14/Clv:2

Yes

organism-modification

PR:000035702 CD14 molecule cleaved 2 GPI-anchored form (human)

hCD14/Clv:2/anchored

Yes

organism-modification

PR:000035703 CD14 molecule cleaved 2 soluble form (human)

hCD14/Clv:2/soluble

Yes

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CD14/Clv:2 forms found in complexes

CD14/Clv:2 Component	Complexes
PR:000002147 CD14/Clv:2/soluble	PR:000025494 LPS:secreted CD14 alpha
	PR:000025496 lipopolysaccharide receptor complex 2
	PR:000025498 lipopolysaccharide receptor complex 4
PR:000002149 CD14/Clv:2/anchored	PR:000025493 LPS:GPI-anchored CD14 complex
	PR:000025495 lipopolysaccharide receptor complex 1
	PR:000025497 lipopolysaccharide receptor complex 3
PR:000035702 hCD14/Clv:2/anchored	PR:000025773 lipopolysaccharide receptor complex 3 (human)
	PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
	PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
	PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
	PR:000037464 LPS:GPI-anchored CD14 complex (human)
PR:000035703 hCD14/Clv:2/soluble	PR:000037463 LPS:secreted CD14 alpha (human)
PR:000035703 hCD14/Clv:2/soluble	PR:000037479 lipopolysaccharide receptor complex 4 (human)
PR:000037470 mCD14/Clv:2/anchored	PR:000037468 LPS:GPI-anchored CD14 complex (mouse)
PR:000037470 mCD14/Clv:2/anchored	PR:000037476 lipopolysaccharide receptor complex 3 (mouse)
PR:000037480 hCD14/Clv:2	PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
	PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
	PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
	PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

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Functional Annotation (GO-centric view)

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Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0032147 activation of protein kinase activity	PR:000036848 CD14/Clv:2	MGI_ref:3836081; PMID:18854309
GO:0034142 toll-like receptor 4 signaling pathway	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_6894
GO:0034142 toll-like receptor 4 signaling pathway	PR:000035703 hCD14/Clv:2/soluble	Reactome:REACT_6894
Molecular Function GO Term	Protein Forms & Complexes	Evidence
GO:0001530 lipopolysaccharide binding	PR:000035703 hCD14/Clv:2/soluble	PMID:9464818
Cellular Location GO Term	Protein Forms & Complexes	Evidence
CL:0000129 microglial cell	PR:000035703 hCD14/Clv:2/soluble	PMID:24659539
GO:0005576 extracellular region	PR:000035703 hCD14/Clv:2/soluble	PMID:2779588; PMID:9665271
GO:0005737 cytoplasm	PR:000036848 CD14/Clv:2	MGI_ref:3836081; PMID:18854309
GO:0005886 plasma membrane	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
	PR:000035702 hCD14/Clv:2/anchored	Reactome:REACT_7740
GO:0016020 membrane	PR:000036848 CD14/Clv:2	MGI_ref:3836081; PMID:18854309