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Protein Ontology report - immunoglobulin heavy chain protein
PR:000050174 - http://purl.obolibrary.org/obo/PR_000050174
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000050174   
  PRO nameimmunoglobulin heavy chain protein 
  Synonyms
PRO-Short-label: EXACT:IgH
  Definition"A protein that is a translation product of some mRNA produced by a somatically recombined immunoglobulin heavy chain locus." [GOC:add, PRO:ADD] 
  CommentRequested by=IEDB. Note: In human, the IgH locus is described by https://www.genenames.org/cgi-bin/genefamilies/set/349. In mouse, the locus is described by MGI:96442
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family3                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000050174

immunoglobulin heavy chain protein

IgH


"A protein that is a translation product of some mRNA produced by a somatically recombined immunoglobulin heavy chain locus." [GOC:add, PRO:ADD]


gene



PR:000050186

IgD heavy chain protein

IgHD


"An immunoglobulin heavy chain protein in which the constant region is encoded by the IgD gene segment." [PRO:DAN]


organism-gene



PR:000050187

IgD heavy chain protein (human)

hIgHD


"An IgD heavy chain protein that is encoded in the genome of human." [PRO:DAN]


Yes
family



PR:000050252

IgG heavy chain protein

IgHG


"An immunoglobulin heavy chain protein in which the constant region is encoded by some IgG gene segment." [PRO:DAN]


seqgroup



PR:000050253

IgG1 heavy chain protein

IgHG1


"An IgG heavy chain protein in which the constant region is encoded by the IgG1 gene segment." [PRO:DAN]


organism-seqgroup



PR:000050291

IgG1 heavy chain protein (human)

hIgHG1


"An IgG1 heavy chain protein that is encoded in the genome of human." [GOC:add, PRO:ADD, PRO:DAN]


Yes
organism-seqgroup



PR:000050297

IgG1 heavy chain protein, secretory isoform (human)

hIgHG1/iso:secretory


"An IgG1 heavy chain protein (human) that is a translation product of some mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA." [GOC:add, PMID:17496345, PMID:9185563, PRO:ADD, PRO:DAN]


Yes
organism-seqgroup



PR:000050301

IgG1 heavy chain protein, membrane-bound isoform (human)

hIgHG1/iso:membrane-bound


"An IgG1 heavy chain protein (human) that is a translation product of some mRNA polyadenylated at a site 3' to the membrane exons." [GOC:add, PMID:17496345, PMID:9185563, PRO:ADD, PRO:DAN]


Yes
seqgroup



PR:000050254

IgG2 heavy chain protein

IgHG2


"An IgG heavy chain protein in which the constant region is encoded by the IgG2 gene segment." [PRO:DAN]


organism-seqgroup



PR:000050292

IgG2 heavy chain protein (human)

hIgHG2


"An IgG2 heavy chain protein that is encoded in the genome of human." [GOC:add, PRO:ADD, PRO:DAN]


Yes
organism-seqgroup



PR:000050298

IgG2 heavy chain protein, secretory isoform (human)

hIgHG2/iso:secretory


"An IgG2 heavy chain protein (human) that is a translation product of some mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA." [GOC:add, PMID:17496345, PMID:9185563, PRO:ADD, PRO:DAN]


Yes
organism-seqgroup



PR:000050302

IgG2 heavy chain protein, membrane-bound isoform (human)

hIgHG2/iso:membrane-bound


"An IgG2 heavy chain protein (human) that is a translation product of some mRNA polyadenylated at a site 3' to the membrane exons." [GOC:add, PMID:17496345, PMID:9185563, PRO:ADD, PRO:DAN]


Yes
seqgroup



PR:000050255

IgG3 heavy chain protein

IgHG3


"An IgG heavy chain protein in which the constant region is encoded by the IgG3 gene segment." [PRO:DAN]


organism-seqgroup



PR:000050293

IgG3 heavy chain protein (human)

hIgHG3


"An IgG3 heavy chain protein that is encoded in the genome of human." [GOC:add, PRO:ADD, PRO:DAN]


Yes
organism-seqgroup



PR:000050299

IgG3 heavy chain protein, secretory isoform (human)

hIgHG3/iso:secretory


"An IgG3 heavy chain protein (human) that is a translation product of some mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA." [GOC:add, PMID:17496345, PMID:9185563, PRO:ADD, PRO:DAN]


Yes
organism-seqgroup



PR:000050303

IgG3 heavy chain protein, membrane-bound isoform (human)

hIgHG3/iso:membrane-bound


"An IgG3 heavy chain protein (human) that is a translation product of some mRNA polyadenylated at a site 3' to the membrane exons." [GOC:add, PMID:17496345, PMID:9185563, PRO:ADD, PRO:DAN]


Yes
seqgroup



PR:000050256

IgG4 heavy chain protein

IgHG4


"An IgG heavy chain protein in which the constant region is encoded by the IgG4 gene segment." [PRO:DAN]


organism-seqgroup



PR:000050294

IgG4 heavy chain protein (human)

hIgHG4


"An IgG4 heavy chain protein that is encoded in the genome of human." [GOC:add, PRO:ADD, PRO:DAN]


Yes
organism-seqgroup



PR:000050300

IgG4 heavy chain protein, secretory isoform (human)

hIgHG4/iso:secretory


"An IgG4 heavy chain protein (human) that is a translation product of some mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA." [GOC:add, PMID:17496345, PMID:9185563, PRO:ADD, PRO:DAN]


Yes
organism-seqgroup



PR:000050304

IgG4 heavy chain protein, membrane-bound isoform (human)

hIgHG4/iso:membrane-bound


"An IgG4 heavy chain protein (human) that is a translation product of some mRNA polyadenylated at a site 3' to the membrane exons." [GOC:add, PMID:17496345, PMID:9185563, PRO:ADD, PRO:DAN]


Yes
seqgroup



PR:000050259

IgG2a heavy chain protein

IgHG2a


"An IgG heavy chain protein in which the constant region is encoded by the IgG2a gene segment." [PRO:DAN]


seqgroup



PR:000050260

IgG2b heavy chain protein

IgHG2b


"An IgG heavy chain protein in which the constant region is encoded by the IgG2b gene segment." [PRO:DAN]


seqgroup



PR:000050261

IgG2c heavy chain protein

IgHG2c


"An IgG heavy chain protein in which the constant region is encoded by the IgG2c gene segment." [PRO:DAN]


seqgroup



PR:000050295

IgG heavy chain protein, secretory isoform

IgHG/iso:secretory


"An IgG heavy chain protein that is a translation product of some mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA." [GOC:add, PMID:17496345, PMID:9185563, PRO:ADD, PRO:DAN]


seqgroup



PR:000050296

IgG heavy chain protein, membrane-bound isoform

IgHG/iso:membrane-bound


"An IgG heavy chain protein that is a translation product of some mRNA polyadenylated at a site 3' to the membrane exons." [GOC:add, PMID:17496345, PMID:9185563, PRO:ADD, PRO:DAN]


seqgroup



PR:000050257

IgM heavy chain protein

IgHM


"An immunoglobulin heavy chain protein in which the constant region is encoded by the IgM gene segment." [PRO:DAN]


seqgroup



PR:000050258

IgE heavy chain protein

IgHE


"An immunoglobulin heavy chain protein in which the constant region is encoded by the IgE gene segment." [PRO:DAN]


seqgroup



PR:000050465

IgY heavy chain protein

IgHY


"An immunoglobulin heavy chain protein in which the constant region is encoded by the IgY gene segment." [PRO:DAN]


seqgroup



PR:000050593

IgN heavy chain protein

IgHN


"An immunoglobulin heavy chain protein in which the constant region is encoded by the IgN gene segment." [PRO:DAN]


family



PR:000050176

IgA heavy chain protein

IgHA


"An immunoglobulin heavy chain protein in which the constant region is encoded either by the IgA1 gene segment or the IgA2 gene segment." [PRO:DAN]


gene



PR:000050177

IgA1 heavy chain protein

IgHA1


"An IgA heavy chain protein in which the constant region is encoded by the IgA1 gene segment." [PRO:DAN]


organism-gene



PR:000050179

IgA1 heavy chain protein (human)

hIgHA1


"An IgA1 heavy chain protein that is encoded in the genome of human." [PRO:DAN]


Yes
organism-seqgroup



PR:000050376

IgA1 heavy chain protein, secretory isoform (human)

hIgHA1/iso:secretory


"An IgA1 heavy chain protein, secretory isoform that is encoded in the genome of human. This is a translation product of an IgA1 mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA." [GOC:add, PRO:ADD, PRO:DAN]


Yes
organism-seqgroup



PR:000050377

IgA1 heavy chain protein, membrane bound isoform (human)

hIgHA1/iso:membrane-bound


"An IgA1 heavy chain protein, membrane-bound isoform that is encoded in the genome of human. This is a translation product of an IgA1 mRNA polyadenylated at a site 3' to the membrane exons." [GOC:add, PRO:ADD, PRO:DAN]


Yes
seqgroup



PR:000050372

IgA1 heavy chain protein, secretory isoform

IgHA1/iso:secretory


"An IgA1 heavy chain protein that is a translation product of some mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA." [GOC:add, PRO:ADD, PRO:DAN]


organism-seqgroup



PR:000050376

IgA1 heavy chain protein, secretory isoform (human)

hIgHA1/iso:secretory


"An IgA1 heavy chain protein, secretory isoform that is encoded in the genome of human. This is a translation product of an IgA1 mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA." [GOC:add, PRO:ADD, PRO:DAN]


Yes
seqgroup



PR:000050373

IgA1 heavy chain protein, membrane-bound isoform

IgHA1/iso:membrane-bound


"An IgA1 heavy chain protein that is a translation product of some mRNA polyadenylated at a site 3' to the membrane exons." [GOC:add, PRO:ADD, PRO:DAN]


organism-seqgroup



PR:000050377

IgA1 heavy chain protein, membrane bound isoform (human)

hIgHA1/iso:membrane-bound


"An IgA1 heavy chain protein, membrane-bound isoform that is encoded in the genome of human. This is a translation product of an IgA1 mRNA polyadenylated at a site 3' to the membrane exons." [GOC:add, PRO:ADD, PRO:DAN]


Yes
gene



PR:000050178

IgA2 heavy chain protein

IgHA2


"An IgA heavy chain protein in which the constant region is encoded by the IgA2 gene segment." [PRO:DAN]


organism-gene



PR:000050180

IgA2 heavy chain protein (human)

hIgHA2


"An IgA2 heavy chain protein that is encoded in the genome of human." [PRO:DAN]


Yes
organism-seqgroup



PR:000050378

IgA2 heavy chain protein, secretory isoform (human)

hIgHA2/iso:secretory


"An IgA2 heavy chain protein, secretory isoform that is encoded in the genome of human. This is a translation product of an IgA2 mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA." [GOC:add, PRO:ADD, PRO:DAN]


Yes
organism-seqgroup



PR:000050379

IgA2 heavy chain protein, membrane bound isoform (human)

hIgHA2/iso:membrane-bound


"An IgA2 heavy chain protein, membrane-bound isoform that is encoded in the genome of human. This is a translation product of an IgA2 mRNA polyadenylated at a site 3' to the membrane exons." [GOC:add, PRO:ADD, PRO:DAN]


Yes
seqgroup



PR:000050374

IgA2 heavy chain protein, secretory isoform

IgHA2/iso:secretory


"An IgA2 heavy chain protein that is a translation product of some mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA." [GOC:add, PRO:ADD, PRO:DAN]


organism-seqgroup



PR:000050378

IgA2 heavy chain protein, secretory isoform (human)

hIgHA2/iso:secretory


"An IgA2 heavy chain protein, secretory isoform that is encoded in the genome of human. This is a translation product of an IgA2 mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA." [GOC:add, PRO:ADD, PRO:DAN]


Yes
seqgroup



PR:000050375

IgA2 heavy chain protein, membrane-bound isoform

IgHA2/iso:membrane-bound


"An IgA2 heavy chain protein that is a translation product of some mRNA polyadenylated at a site 3' to the membrane exons." [GOC:add, PRO:ADD, PRO:DAN]


organism-seqgroup



PR:000050379

IgA2 heavy chain protein, membrane bound isoform (human)

hIgHA2/iso:membrane-bound


"An IgA2 heavy chain protein, membrane-bound isoform that is encoded in the genome of human. This is a translation product of an IgA2 mRNA polyadenylated at a site 3' to the membrane exons." [GOC:add, PRO:ADD, PRO:DAN]


Yes
seqgroup



PR:000050594

IgA heavy chain protein, secretory isoform

IgHA/iso:secretory


"An IgA heavy chain protein that is a translation product of some mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA." [GOC:add, PRO:ADD, PRO:DAN]


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IgH forms found in complexes   

IgH Component
Complexes
PR:000050179 hIgHA1 PR:000050157 IgA1 immunoglobulin complex (human)
PR:000050180 hIgHA2 PR:000050158 IgA2 immunoglobulin complex (human)
PR:000050187 hIgHD PR:000050170 IgD immunoglobulin complex (human)
PR:000050171 IgD immunoglobulin complex, circulating (human)
PR:000050172 IgD B cell receptor complex (human)
PR:000050173 IgD immunoglobulin complex, GPI-anchored (human)
PR:000050291 hIgHG1 PR:000050305 IgG1 immunoglobulin complex (human)
PR:000050292 hIgHG2 PR:000050306 IgG2 immunoglobulin complex (human)
PR:000050293 hIgHG3 PR:000050307 IgG3 immunoglobulin complex (human)
PR:000050294 hIgHG4 PR:000050308 IgG4 immunoglobulin complex (human)
PR:000050297 hIgHG1/iso:secretory PR:000050309 IgG1 immunoglobulin complex, circulating (human)
PR:000050298 hIgHG2/iso:secretory PR:000050310 IgG2 immunoglobulin complex, circulating (human)
PR:000050299 hIgHG3/iso:secretory PR:000050311 IgG3 immunoglobulin complex, circulating (human)
PR:000050300 hIgHG4/iso:secretory PR:000050312 IgG4 immunoglobulin complex, circulating (human)
PR:000050301 hIgHG1/iso:membrane-bound PR:000050313 IgG1 B cell receptor complex (human)
PR:000050302 hIgHG2/iso:membrane-bound PR:000050314 IgG2 B cell receptor complex (human)
PR:000050303 hIgHG3/iso:membrane-bound PR:000050315 IgG3 B cell receptor complex (human)
PR:000050304 hIgHG4/iso:membrane-bound PR:000050316 IgG4 B cell receptor complex (human)
PR:000050376 hIgHA1/iso:secretory PR:000050159 IgA1 immunoglobulin complex, circulating (human)
PR:000050163 monomeric IgA1 immunoglobulin complex (human)
PR:000050377 hIgHA1/iso:membrane-bound PR:000050161 IgA1 B cell receptor complex (human)
PR:000050378 hIgHA2/iso:secretory PR:000050160 IgA2 immunoglobulin complex, circulating (human)
PR:000050379 hIgHA2/iso:membrane-bound PR:000050162 IgA2 B cell receptor complex (human)