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Protein Ontology report - mitotic checkpoint serine/threonine-protein kinase BUB1 (human)
PR:O43683 - http://purl.obolibrary.org/obo/PR_O43683
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:O43683   
  PRO namemitotic checkpoint serine/threonine-protein kinase BUB1 (human) 
  Synonyms
PRO-Short-label: EXACT:hBUB1
Gene-based: RELATED:BUB1 | BUB1L
Other: EXACT:BUB1A (human)
  Definition"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of human." [PMID:10749118, PMID:11030144, PMID:11792804, PMID:12719470, PMID:15190214, PMID:15525512, PMID:15592459, PMID:16760428, PMID:17671183, PMID:17785528, PMID:20016069, PMID:20624902, PMID:20703093, PRO:KER] 
  PRO Categoryorganism-gene 
  ParentPR:000004854 mitotic checkpoint serine/threonine-protein kinase BUB1
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:1148 BUB1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 17                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:O43683
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human)
hBUB1
Yes
Yes
organism-sequence


PR:O43683-1 mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h1 (human)
hBUB1/iso:h1

organism-sequence


PR:O43683-2 mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h2 (human)
hBUB1/iso:h2

organism-sequence


PR:O43683-3 mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h3 (human)
hBUB1/iso:h3

organism-modification


PR:000035399 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (human)
hBUB1/Phos:2

organism-modification


PR:000035405 mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (human)
hBUB1/PhosRes-
Yes
organism-modification


PR:000035407 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (human)
hBUB1/Phos:4
Yes
organism-modification


PR:000035412 mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 7 (human)
hBUB1/Phos:7
Yes
Yes
organism-modification


PR:000035418 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8 (human)
hBUB1/Phos:8

organism-modification


PR:000035421 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 (human)
hBUB1/Phos:10
Yes
organism-modification


PR:000065566 mitotic checkpoint serine/threonine-protein kinase BUB1 cysteinylated 1 (human)
hBUB1/Cyst:1

organism-modification


PR:000066031 mitotic checkpoint serine/threonine-protein kinase BUB1 cysteinylated 2 (human)
hBUB1/Cyst:2

organism-modification


PR:000071538 mitotic checkpoint serine/threonine-protein kinase BUB1 methylated 1 (human)
hBUB1/Me:1

organism-modification


PR:000072604 mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 1 (human)
hBUB1/Deam:1

organism-modification


PR:000073548 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 (human)
hBUB1/Phos:1

organism-modification


PR:000073549 mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 2 (human)
hBUB1/Deam:2

organism-modification


PR:000076189 mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 3 (human)
hBUB1/Deam:3

organism-modification


PR:000076708 mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 4 (human)
hBUB1/Deam:4

organism-modification


PR:000076926 mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 5 (human)
hBUB1/Deam:5

organism-modification


PR:000078756 mitotic checkpoint serine/threonine-protein kinase BUB1 methylated 2 (human)
hBUB1/Me:2

organism-modification


PR:000079803 mitotic checkpoint serine/threonine-protein kinase BUB1 methylated 3 (human)
hBUB1/Me:3

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hBUB1 forms found in complexes   

hBUB1 Component
 Complexes
PR:000035412 hBUB1/Phos:7 PR:000035581 phosphoBUB1:PLK1 complex (human)
PR:O43683 hBUB1 PR:000035564 BUB1:BUB3 complex (human)
PR:000035567 BUB1:BUB3:MAD1L1 complex (human)
PR:000035576 BUB1:BUB3:APC complex (human)
PR:000035577 BUB1:phosphoBUB1B complex (human)
PR:000035579 BUB1:unphosphoBUB1B complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035405 hBUB1/PhosRes- enablesNOT GO:0005515 protein binding with PR:P53350 hPLK1 PMID:16760428
located_inGO:0000776 kinetochore PMID:16760428
PR:000035407 hBUB1/Phos:4 enablesincreased GO:0004672 protein kinase activity relative to PR:000035405 hBUB1/PhosRes- PMID:15525512
PR:000035412 hBUB1/Phos:7
Example: UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047		 acts_upstream_of_or_withinGO:0034501 protein localization to kinetochore PMID:16760428
enablesincreased GO:0005515 protein binding with PR:Q9NQS7 hINCENP PMID:16760428
PR:000035421 hBUB1/Phos:10
Example: UniProtKB:O43683-1, Ser-314, MOD:00046		 acts_upstream_of_or_withinGO:0006281 DNA repair PMID:22071147
GO:0031577 spindle checkpoint signaling PMID:22099307
enablesincreased GO:0004672 protein kinase activity relative to PR:000035405 hBUB1/PhosRes- PMID:22071147
located_inGO:0035861 site of double-strand break PMID:22071147
PR:O43683 hBUB1 acts_upstream_of_or_withinGO:0007059 chromosome segregation PMID:16580887
GO:0007062 sister chromatid cohesion PMID:16580887
GO:0031577 spindle checkpoint signaling PMID:15525512
GO:0043066 negative regulation of apoptotic process PMID:19252416
GO:0043069 negative regulation of programmed cell death PMID:20057499
GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
enablesGO:0004672 protein kinase activity PMID:10198256
GO:0005515 protein binding with PR:O60566 BUB1B PMID:10198256
GO:0005515 protein binding with PR:P04637-1 PMID:10198256
GO:0005515 protein binding with PR:P25054 APC PMID:10198256
GO:0005515 protein binding with PR:P53350 hPLK1 PMID:10198256
GO:0005515 protein binding with PR:Q8NG31 AF15q14 (human) PMID:10198256
GO:0005515 protein binding with PR:Q9Y6D9 hMAD1 PMID:10198256
GO:0005515 protein binding PMID:10198256
located_inGO:0000776 kinetochore PMID:20624902
GO:0000939 inner kinetochore PMID:11792804
GO:0000940 outer kinetochore PMID:11792804; PMID:16760428