PRO Term |
GO Annotation |
Evidence |
PR:000035405 hBUB1/PhosRes-
"A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in human." [PRO:CNA] |
enables | NOT GO:0005515 protein binding with PR:P53350 hPLK1 |
PMID:16760428 |
located_in | GO:0000776 kinetochore |
PMID:16760428 |
PR:000035407 hBUB1/Phos:4 hBUB1 phosphorylated "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 in human." [PMID:11792804, PMID:15525512, PRO:KER] |
enables | increased GO:0004672 protein kinase activity relative to PR:000035405 hBUB1/PhosRes- |
PMID:15525512 |
PR:000035412 hBUB1/Phos:7 UniProtKB:O43683, Ser-593, MOD:00046|Thr-609, MOD:00047 | UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047 "A BUB1 CDK-consensus sites phosphorylated form in human. Phosphorylation occurs during mitosis and spindle disruption (e.g. with nocodazole). Thr-609 phosphorylation is critical for interaction with PLK1. Example: UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047." [PMID:16760428, PRO:KER] |
acts_upstream_of_or_within | GO:0034501 protein localization to kinetochore |
PMID:16760428 |
enables | increased GO:0005515 protein binding with PR:Q9NQS7 hINCENP |
PMID:16760428 |
PR:000035421 hBUB1/Phos:10 UniProtKB:O43683-1, Ser-314, MOD:00046 | hBUB1 phosphorylated "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 in human. Example: UniProtKB:O43683-1, Ser-314, MOD:00046." [PMID:22071147, PMID:22099307, PRO:KER] |
acts_upstream_of_or_within | GO:0006281 DNA repair |
PMID:22071147 |
GO:0031577 spindle checkpoint signaling |
PMID:22099307 |
enables | increased GO:0004672 protein kinase activity relative to PR:000035405 hBUB1/PhosRes- |
PMID:22071147 |
located_in | GO:0035861 site of double-strand break |
PMID:22071147 |
PR:O43683 hBUB1 BUB1 | BUB1L | BUB1A (human) "A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of human." [PMID:10749118, PMID:11030144, PMID:11792804, PMID:12719470, PMID:15190214, PMID:15525512, PMID:15592459, PMID:16760428, PMID:17671183, PMID:17785528, PMID:20016069, PMID:20624902, PMID:20703093, PRO:KER] |
acts_upstream_of_or_within | GO:0007059 chromosome segregation |
PMID:16580887 |
GO:0007062 sister chromatid cohesion |
PMID:16580887 |
GO:0031577 spindle checkpoint signaling |
PMID:15525512 |
GO:0043066 negative regulation of apoptotic process |
PMID:19252416 |
GO:0043069 negative regulation of programmed cell death |
PMID:20057499 |
GO:0071459 protein localization to chromosome, centromeric region |
PMID:21658950 |
GO:0071459 protein localization to chromosome, centromeric region |
PMID:21658950 |
GO:0071459 protein localization to chromosome, centromeric region |
PMID:21658950 |
GO:0071459 protein localization to chromosome, centromeric region |
PMID:21658950 |
enables | GO:0004672 protein kinase activity |
PMID:10198256 |
GO:0005515 protein binding with PR:O60566 BUB1B |
PMID:10198256 |
GO:0005515 protein binding with PR:P04637-1 |
PMID:10198256 |
GO:0005515 protein binding with PR:P25054 APC |
PMID:10198256 |
GO:0005515 protein binding with PR:P53350 hPLK1 |
PMID:10198256 |
GO:0005515 protein binding with PR:Q8NG31 AF15q14 (human) |
PMID:10198256 |
GO:0005515 protein binding with PR:Q9Y6D9 hMAD1 |
PMID:10198256 |
GO:0005515 protein binding |
PMID:10198256 |
located_in | GO:0000776 kinetochore |
PMID:20624902 |
GO:0000939 inner kinetochore |
PMID:11792804 |
GO:0000940 outer kinetochore |
PMID:11792804; PMID:16760428 |