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Protein Ontology report - tyrosine-protein kinase Lck (human)
PR:P06239 - http://purl.obolibrary.org/obo/PR_P06239
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P06239   
  PRO nametyrosine-protein kinase Lck (human) 
  Synonyms
PRO-Short-label: EXACT:hLCK
Gene-based: RELATED:LCK
Other: EXACT:leukocyte C-terminal Src kinase (human) | LSK (human) | lymphocyte cell-specific protein-tyrosine kinase (human) | p56-LCK (human) | protein YT16 (human) | proto-oncogene Lck (human) | T cell-specific protein-tyrosine kinase (human)
  Definition"A tyrosine-protein kinase Lck that is encoded in the genome of human." [PRO:DNx] 
  PRO Categoryorganism-gene 
  ParentPR:000002998 tyrosine-protein kinase Lck
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:6524 LCK (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P06239
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:P06239

tyrosine-protein kinase Lck (human)

hLCK


"A tyrosine-protein kinase Lck that is encoded in the genome of human." [PRO:DNx]


Yes
organism-sequence



PR:P06239-1

tyrosine-protein kinase Lck isoform Long (human)

hLCK/iso:Long


"A tyrosine-protein kinase Lck isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036619

tyrosine-protein kinase Lck isoform 1 phosphorylated 1 (human)

hLCK/iso:1/Phos:1


"A tyrosine-protein kinase Lck isoform 1 phosphorylated 1 in human. UniProtKB:P06239-1, Tyr-394/Tyr-505, MOD:00048." [PMID:9043947, PRO:CL]

Yes

organism-modification



PR:000036622

tyrosine-protein kinase Lck isoform 1 phosphorylated 2 (human)

hLCK/iso:1/Phos:2


"A tyrosine-protein kinase Lck isoform 1 phosphorylated 2 in human. UniProtKB:P06239-1, Tyr-394, MOD:00048." [PMID:9043947, PRO:CL]

Yes

organism-sequence



PR:P06239-2

tyrosine-protein kinase Lck isoform Short (human)

hLCK/iso:Short


"A tyrosine-protein kinase Lck (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06239-2." [PRO:DNx, UniProtKB:P06239]


organism-sequence



PR:P06239-3

tyrosine-protein kinase Lck isoform h3 (human)

hLCK/iso:h3


"A tyrosine-protein kinase Lck (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06239-3." [PRO:DNx, UniProtKB:P06239]


organism-modification



PR:000048171

tyrosine-protein kinase Lck phosphorylated 2 (human)

hLCK/Phos:2


"A tyrosine-protein kinase Lck (human) that has been phosphorylated on the residue at the position equivalent to Tyr-394 of the amino acid sequence represented by UniProtKB:P06239. UniProtKB:P06239, Tyr-394, MOD:00048." [PRO:DNx, Reactome:R-HSA-202308, Reactome:R-HSA-8857940]


organism-modification



PR:000048172

tyrosine-protein kinase Lck phosphorylated 3 (human)

hLCK/Phos:3


"A tyrosine-protein kinase Lck (human) that has been phosphorylated on the residue at the position equivalent to Tyr-505 of the amino acid sequence represented by UniProtKB:P06239. UniProtKB:P06239, Tyr-505, MOD:00048." [PRO:DNx, Reactome:R-HSA-202159]


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hLCK forms found in complexes   

hLCK Component
Complexes
PR:P06239 hLCK PR:000028449 CD4:Lck complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036619 hLCK/iso:1/Phos:1
UniProtKB:P06239-1, Tyr-394/Tyr-505, MOD:00048
enablesdecreased GO:0016301 kinase activity relative to PR:000036622 hLCK/iso:1/Phos:2 PMID:9043947
PR:000036622 hLCK/iso:1/Phos:2
UniProtKB:P06239-1, Tyr-394, MOD:00048
enablesGO:0016301 kinase activity PMID:9043947
GO:0044877 protein-containing complex binding PMID:9043947