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Protein Ontology report - monocyte differentiation antigen CD14 (human)
PR:P08571 - http://purl.obolibrary.org/obo/PR_P08571
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P08571   
  PRO namemonocyte differentiation antigen CD14 (human) 
  Synonyms
PRO-Short-label: EXACT:hCD14
Gene-based: RELATED:CD14
Other: EXACT:My23 antigen (human) | myeloid cell-specific leucine-rich glycoprotein (human)
  Definition"A CD14 molecule that is encoded in the genome of human." [PRO:WCB, UniProtKB:P08571] 
  PRO Categoryorganism-gene 
  ParentPR:000001889 CD14 molecule
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:1628 CD14 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification0                                                  Organism-Modification 14                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P08571
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P08571 monocyte differentiation antigen CD14 (human)
hCD14
Yes
organism-modification


PR:000036615 CD14 molecule cleaved 1 soluble form (human)
hCD14/Clv:1/soluble
Yes
organism-modification


PR:000036945 CD14 molecule cleaved and soluble form (human)
hCD14/ClvPrd/soluble

organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human)
hCD14/Clv:2/soluble

organism-modification


PR:000036615 CD14 molecule cleaved 1 soluble form (human)
hCD14/Clv:1/soluble

organism-modification


PR:000037480 CD14 molecule cleaved 2 (human)
hCD14/Clv:2

Yes
organism-modification


PR:000035702 CD14 molecule cleaved 2 GPI-anchored form (human)
hCD14/Clv:2/anchored
Yes
Yes
organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human)
hCD14/Clv:2/soluble
Yes
Yes
organism-modification


PR:000050392 presepsin (human)
hPSEP

organism-modification


PR:000054476 monocyte differentiation antigen CD14 N-glycosylated 1 (human)
hCD14/NGlyco:1

organism-modification


PR:000054477 monocyte differentiation antigen CD14 O-glycosylated 1 (human)
hCD14/OGlyco:1

organism-modification


PR:000054478 monocyte differentiation antigen CD14 O-glycosylated 2 (human)
hCD14/OGlyco:2

organism-modification


PR:000054479 monocyte differentiation antigen CD14 O-glycosylated 3 (human)
hCD14/OGlyco:3

organism-modification


PR:000054480 monocyte differentiation antigen CD14 O-glycosylated 4 (human)
hCD14/OGlyco:4

organism-modification


PR:000054481 monocyte differentiation antigen CD14 O-glycosylated 5 (human)
hCD14/OGlyco:5

organism-modification


PR:000065690 monocyte differentiation antigen CD14 cysteinylated 1 (human)
hCD14/Cyst:1

organism-modification


PR:000079106 monocyte differentiation antigen CD14 deaminated 1 (human)
hCD14/Deam:1

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hCD14 forms found in complexes   

hCD14 Component
 Complexes
PR:000035702 hCD14/Clv:2/anchored PR:000025773 lipopolysaccharide receptor complex 3 (human)
PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037464 LPS:GPI-anchored CD14 complex (human)
PR:000035703 hCD14/Clv:2/soluble PR:000037463 LPS:secreted CD14 alpha (human)
PR:000037479 lipopolysaccharide receptor complex 4 (human)
PR:000037480 hCD14/Clv:2 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035702 hCD14/Clv:2/anchored
UniProtKB:P08571, 20-345, Asn-345, MOD:00167		 acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
located_inGO:0005886 plasma membrane Reactome:REACT_7740
GO:0005886 plasma membrane Reactome:REACT_7740
PR:000035703 hCD14/Clv:2/soluble acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
enablesGO:0001530 lipopolysaccharide binding PMID:9464818
located_inCL:0000129 microglial cell PMID:24659539
GO:0005576 extracellular region PMID:2779588; PMID:9665271
PR:000036615 hCD14/Clv:1/soluble
UniProtKB:P08571, 20-367		 located_inGO:0005576 extracellular region PMID:7519994
PR:P08571 hCD14 located_inNOT CL:0000127 astrocyte PMID:24659539