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Protein Ontology report - cyclin-dependent kinase inhibitor 1B isoform 1 (human)
PR:P46527-1 - http://purl.obolibrary.org/obo/PR_P46527-1
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P46527-1   
  PRO namecyclin-dependent kinase inhibitor 1B isoform 1 (human) 
  Synonyms
PRO-Short-label: EXACT:hCDKN1B/iso:1
  Definition"A cyclin-dependent kinase inhibitor 1B isoform 1 that is encoded in the genome of human." [PRO:CNA] 
  PRO Categoryorganism-sequence 
  ParentPR:000003091 cyclin-dependent kinase inhibitor 1B isoform 1
PR:P46527 cyclin-dependent kinase inhibitor 1B (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P46527-1
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-sequence


PR:P46527-1
cyclin-dependent kinase inhibitor 1B isoform 1 (human)
hCDKN1B/iso:1
"A cyclin-dependent kinase inhibitor 1B isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000025750
cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2 (human)
hCDKN1B/iso:1/Phos:2
"A cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2 in human. Phosphorylation at this site promotes subsequent Cdk2-mediated phosphorylation at Thr-187. UniProtKB:P46527-1, Tyr-88, MOD:00048." [PMID:17254966, PRO:JAN]
Yes
organism-modification


PR:000025752
cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 3 (human)
hCDKN1B/iso:1/Phos:3
"A cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 3 in human. UniProtKB:P46527-1, Tyr-88, MOD:00048|Thr-187, MOD:00047." [PMID:17254966, PRO:CNA]

organism-modification


PR:000036634
cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 1 (human)
hCDKN1B/iso:1/Phos:1
"A cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 1 in human. UniProtKB:P46527-1, Thr-157, MOD:00047." [PMID:12244301, PMID:15057270, PRO:JAN]
Yes
organism-modification


PR:000045370
cyclin-dependent kinase inhibitor 1B isoform 1 unphosphorylated 2 (human)
hCDKN1B/iso:1/UnPhos:2
"A cyclin-dependent kinase inhibitor 1B isoform 1 (human) that lacks phosphorylation at Tyr-88. UniProtKB:P46527-1, Tyr-88, PR:000026291." [PRO:CNA]
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0008284 positive regulation of cell population proliferationPR:000036634 hCDKN1B/iso:1/Phos:1 PMID:12244301
GO:0008285 negative regulation of cell population proliferationPR:000045370 hCDKN1B/iso:1/UnPhos:2 PMID:12244301
GO:0051318 G1 phasePR:000025750 hCDKN1B/iso:1/Phos:2 PMID:17254966
PR:000045370 hCDKN1B/iso:1/UnPhos:2 PMID:17254966

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activityPR:000025750 hCDKN1B/iso:1/Phos:2 PMID:17254966
PR:000045370 hCDKN1B/iso:1/UnPhos:2 PMID:17254966
GO:0005515 protein bindingPR:000025750 hCDKN1B/iso:1/Phos:2 PMID:17254966
PR:000025750 hCDKN1B/iso:1/Phos:2 PMID:17254966
PR:000025750 hCDKN1B/iso:1/Phos:2 PMID:17254966
PR:000025750 hCDKN1B/iso:1/Phos:2 PMID:17254966
PR:000025750 hCDKN1B/iso:1/Phos:2 PMID:17254966
PR:000025750 hCDKN1B/iso:1/Phos:2 PMID:17254966
PR:000036634 hCDKN1B/iso:1/Phos:1 PMID:15057270
PR:000036634 hCDKN1B/iso:1/Phos:1 PMID:15057270
PR:000036634 hCDKN1B/iso:1/Phos:1 PMID:15057270
PR:000036634 hCDKN1B/iso:1/Phos:1 PMID:15057270
PR:000045370 hCDKN1B/iso:1/UnPhos:2 PMID:12244301
GO:0044877 protein-containing complex bindingPR:000025750 hCDKN1B/iso:1/Phos:2 PMID:17254966
PR:000045370 hCDKN1B/iso:1/UnPhos:2 PMID:17254966

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005634 nucleusPR:000045370 hCDKN1B/iso:1/UnPhos:2 PMID:12244301
GO:0005737 cytoplasmPR:000036634 hCDKN1B/iso:1/Phos:1 PMID:15057270
GO:0005829 cytosolPR:000036634 hCDKN1B/iso:1/Phos:1 PMID:12244301