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Protein Ontology report - tyrosine-protein kinase BTK (human)
PR:Q06187 - http://purl.obolibrary.org/obo/PR_Q06187
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:Q06187   
  PRO nametyrosine-protein kinase BTK (human) 
  Synonyms
PRO-Short-label: EXACT:hBTK
Gene-based: RELATED:AGMX1 | ATK | BPK | BTK
Other: EXACT:agammaglobulinemia tyrosine kinase (human) | B-cell progenitor kinase (human) | bruton tyrosine kinase (human)
  Definition"A tyrosine-protein kinase BTK that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q06187
  PRO Categoryorganism-gene 
  ParentPR:000002110 tyrosine-protein kinase BTK
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:1133 BTK (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q06187
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:Q06187

tyrosine-protein kinase BTK (human)

hBTK


"A tyrosine-protein kinase BTK that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q06187]


organism-sequence



PR:Q06187-1

tyrosine-protein kinase BTK isoform BTK-A (human)

hBTK/iso:BTK-A


"A tyrosine-protein kinase BTK isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:Q06187-2

tyrosine-protein kinase BTK isoform BTK-C (human)

hBTK/iso:BTK-C


"A tyrosine-protein kinase BTK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q06187-2." [PRO:DNx, UniProtKB:Q06187]


organism-modification



PR:000044351

tyrosine-protein kinase BTK, initiator methionine removed form (human)

hBTK/InitMet-


"A tyrosine-protein kinase BTK, initiator methionine removed form in human. Example: UniProtKB:Q06187-1, 2-659." [PRO:CNA, UniProtKB:Q06187]


Yes
organism-modification



PR:000046518

tyrosine-protein kinase BTK, initiator methionine removed phosphorylated 2 (human)

hBTK/InitMet-/Phos:2


"A tyrosine-protein kinase BTK, initiator methionine removed form (human) that has been post-translationally modified to include phosphotyrosine at positions 223 and 551 of the amino acid sequence represented by UniProtKB:Q06187. UniProtKB:Q06187, 2-659, Tyr-223/Tyr-551, MOD:00048." [PRO:DNx, Reactome:R-HSA-2424454, Reactome:R-HSA-984807]


organism-modification



PR:000046519

tyrosine-protein kinase BTK, initiator methionine removed phosphorylated 1 (human)

hBTK/InitMet-/Phos:1


"A tyrosine-protein kinase BTK, initiator methionine removed form (human) that has been phosphorylated on the residue at the position equivalent to Tyr-551 of the amino acid sequence represented by UniProtKB:Q06187. UniProtKB:Q06187, 2-659, Tyr-551, MOD:00048." [PRO:DNx, Reactome:R-HSA-2685603]


organism-modification



PR:000045882

tyrosine-protein kinase BTK phosphorylated 1 (human)

hBTK/Phos:1


"A tyrosine-protein kinase BTK (human) that has been phosphorylated on the residue at the position equivalent to Tyr-551 of the amino acid sequence represented by UniProtKB:Q06187-1. Example: UniProtKB:Q06187-1, Tyr-551, MOD:00048." [iPTMnet:Q06187, PMID:11226282, PMID:7565679]


organism-modification



PR:000069637

tyrosine-protein kinase BTK deaminated 1 (human)

hBTK/Deam:1


"A tyrosine-protein kinase BTK (human) that has been deaminated on the residue at the position equivalent to Gln-103 of the amino acid sequence represented by UniProtKB:Q06187-1. Example: UniProtKB:Q06187-1, Gln-103, MOD:00685." [IEDB_epitope:1353605, PRO:DNx]


organism-modification



PR:000070839

tyrosine-protein kinase BTK deaminated 2 (human)

hBTK/Deam:2


"A tyrosine-protein kinase BTK (human) that has been deaminated on the residue at the position equivalent to Asn-381 of the amino acid sequence represented by UniProtKB:Q06187-1. Example: UniProtKB:Q06187-1, Asn-381, MOD:00684." [IEDB_epitope:1376974, PRO:DNx]


organism-modification



PR:000077962

tyrosine-protein kinase BTK methylated 1 (human)

hBTK/Me:1


"A tyrosine-protein kinase BTK (human) that has been methylated on the residue at the position equivalent to Cys-145 of the amino acid sequence represented by UniProtKB:Q06187-1. Example: UniProtKB:Q06187-1, Cys-145, MOD:00660." [IEDB_epitope:1018627, PRO:DNx]


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hBTK forms found in complexes   

hBTK Component
Complexes
PR:000044351 hBTK/InitMet- PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)