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Protein Ontology report - latent TGF-beta-binding protein
PR:000000018 - http://purl.obolibrary.org/obo/PR_000000018
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000018   
  PRO namelatent TGF-beta-binding protein 
  Definition"A protein that is similar in overall domain structure to fibrillins that is mainly composed of two types of repeated protein domains, namely epidermal growth factor (EGF-like) and TB (8-Cys-like repeats). The latent TGF-beta-binding protein is characterized by having four of the TB domains." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 6                                        
         Sequence2                                                  Organism-Sequence 8                                        
         Modification3                                                  Organism-Modification 66                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037569
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000018 latent TGF-beta-binding protein, IFNG
Yes
gene


PR:000000101 latent TGF-beta-binding protein 1, LTBP1

organism-gene


PR:Q00918 latent-transforming growth factor beta-binding protein 1 (rat), rLTBP1

organism-gene


PR:Q14766 latent-transforming growth factor beta-binding protein 1 (human), hLTBP1

organism-sequence


PR:Q14766-1 latent-transforming growth factor beta-binding protein 1 isoform Long (human), hLTBP1/iso:Long
Yes
organism-modification


PR:000036463 latent TGF-beta-binding protein 1 isoform 1, signal peptide removed form (human), hLTBP1/iso:1/SigPep-
Yes
organism-sequence


PR:Q14766-2 latent-transforming growth factor beta-binding protein 1 isoform Short (human), hLTBP1/iso:Short

organism-modification


PR:000036461 latent TGF-beta-binding protein 1 isoform 2, signal peptide removed form (human), hLTBP1/iso:2/SigPep-
Yes
organism-sequence


PR:Q14766-3 latent-transforming growth factor beta-binding protein 1 isoform h3 (human), hLTBP1/iso:h3

organism-sequence


PR:Q14766-4 latent-transforming growth factor beta-binding protein 1 isoform h4 (human), hLTBP1/iso:h4

organism-sequence


PR:Q14766-5 latent-transforming growth factor beta-binding protein 1 isoform h5 (human), hLTBP1/iso:h5

organism-modification


PR:000048267 latent-transforming growth factor beta-binding protein 1, signal peptide removed form (human), hLTBP1/SigPep-

organism-modification


PR:000036461 latent TGF-beta-binding protein 1 isoform 2, signal peptide removed form (human), hLTBP1/iso:2/SigPep-
Yes
organism-modification


PR:000036463 latent TGF-beta-binding protein 1 isoform 1, signal peptide removed form (human), hLTBP1/iso:1/SigPep-
Yes
organism-modification


PR:000057228 latent-transforming growth factor beta-binding protein 1 N-glycosylated 1 (human), hLTBP1/NGlyco:1

organism-modification


PR:000057229 latent-transforming growth factor beta-binding protein 1 N-glycosylated 2 (human), hLTBP1/NGlyco:2

organism-modification


PR:000057231 latent-transforming growth factor beta-binding protein 1 N-glycosylated 4 (human), hLTBP1/NGlyco:4

organism-modification


PR:000057232 latent-transforming growth factor beta-binding protein 1 N-glycosylated 5 (human), hLTBP1/NGlyco:5

organism-modification


PR:000057233 latent-transforming growth factor beta-binding protein 1 N-glycosylated 6 (human), hLTBP1/NGlyco:6

organism-modification


PR:000057235 latent-transforming growth factor beta-binding protein 1 O-glycosylated 1 (human), hLTBP1/OGlyco:1

organism-modification


PR:000057236 latent-transforming growth factor beta-binding protein 1 O-glycosylated 2 (human), hLTBP1/OGlyco:2

organism-modification


PR:000057237 latent-transforming growth factor beta-binding protein 1 O-glycosylated 3 (human), hLTBP1/OGlyco:3

organism-modification


PR:000057238 latent-transforming growth factor beta-binding protein 1 O-glycosylated 4 (human), hLTBP1/OGlyco:4

organism-modification


PR:000057239 latent-transforming growth factor beta-binding protein 1 O-glycosylated 5 (human), hLTBP1/OGlyco:5

organism-modification


PR:000057240 latent-transforming growth factor beta-binding protein 1 O-glycosylated 6 (human), hLTBP1/OGlyco:6

organism-modification


PR:000057241 latent-transforming growth factor beta-binding protein 1 O-glycosylated 7 (human), hLTBP1/OGlyco:7

organism-modification


PR:000057242 latent-transforming growth factor beta-binding protein 1 O-glycosylated 8 (human), hLTBP1/OGlyco:8

organism-modification


PR:000057243 latent-transforming growth factor beta-binding protein 1 O-glycosylated 9 (human), hLTBP1/OGlyco:9

organism-modification


PR:000057244 latent-transforming growth factor beta-binding protein 1 O-glycosylated 10 (human), hLTBP1/OGlyco:10

organism-modification


PR:000057245 latent-transforming growth factor beta-binding protein 1 O-glycosylated 11 (human), hLTBP1/OGlyco:11

organism-modification


PR:000057246 latent-transforming growth factor beta-binding protein 1 O-glycosylated 12 (human), hLTBP1/OGlyco:12

organism-modification


PR:000057247 latent-transforming growth factor beta-binding protein 1 O-glycosylated 13 (human), hLTBP1/OGlyco:13

organism-modification


PR:000057248 latent-transforming growth factor beta-binding protein 1 O-glycosylated 14 (human), hLTBP1/OGlyco:14

organism-modification


PR:000057249 latent-transforming growth factor beta-binding protein 1 O-glycosylated 15 (human), hLTBP1/OGlyco:15

organism-modification


PR:000057250 latent-transforming growth factor beta-binding protein 1 O-glycosylated 16 (human), hLTBP1/OGlyco:16

organism-modification


PR:000057251 latent-transforming growth factor beta-binding protein 1 O-glycosylated 17 (human), hLTBP1/OGlyco:17

organism-modification


PR:000057252 latent-transforming growth factor beta-binding protein 1 O-glycosylated 18 (human), hLTBP1/OGlyco:18

organism-modification


PR:000057253 latent-transforming growth factor beta-binding protein 1 O-glycosylated 19 (human), hLTBP1/OGlyco:19

organism-modification


PR:000057254 latent-transforming growth factor beta-binding protein 1 O-glycosylated 20 (human), hLTBP1/OGlyco:20

organism-modification


PR:000060399 latent-transforming growth factor beta-binding protein 1, signal peptide removed phosphorylated form (human), hLTBP1/SigPep-/PhosRes+

organism-modification


PR:000066752 latent-transforming growth factor beta-binding protein 1 cysteinylated 1 (human), hLTBP1/Cyst:1

organism-modification


PR:000079465 latent-transforming growth factor beta-binding protein 1 cysteinylated 2 (human), hLTBP1/Cyst:2

organism-modification


PR:000079568 latent-transforming growth factor beta-binding protein 1 cysteinylated 3 (human), hLTBP1/Cyst:3

organism-gene


PR:Q8CG19 latent-transforming growth factor beta-binding protein 1 (mouse), mLTBP1

organism-sequence


PR:Q8CG19-1 latent-transforming growth factor beta-binding protein 1 isoform Long (mouse), mLTBP1/iso:Long

organism-sequence


PR:Q8CG19-2 latent-transforming growth factor beta-binding protein 1 isoform Short (mouse), mLTBP1/iso:Short

organism-modification


PR:000036462 latent TGF-beta-binding protein 1 isoform 2, signal peptide removed form (mouse), mLTBP1/iso:2/SigPep-
Yes
organism-sequence


PR:Q8CG19-3 latent-transforming growth factor beta-binding protein 1 isoform m3 (mouse), mLTBP1/iso:m3

sequence


PR:000000285 latent TGF-beta-binding protein 1 isoform 1, LTBP1/iso:1

organism-sequence


PR:Q14766-1 latent-transforming growth factor beta-binding protein 1 isoform Long (human), hLTBP1/iso:Long
Yes
organism-modification


PR:000036463 latent TGF-beta-binding protein 1 isoform 1, signal peptide removed form (human), hLTBP1/iso:1/SigPep-
Yes
organism-sequence


PR:Q8CG19-1 latent-transforming growth factor beta-binding protein 1 isoform Long (mouse), mLTBP1/iso:Long

modification


PR:000000553 latent TGF-beta-binding protein 1 isoform 1, signal peptide removed form, LTBP1/iso:1/SigPep-

organism-modification


PR:000036463 latent TGF-beta-binding protein 1 isoform 1, signal peptide removed form (human), hLTBP1/iso:1/SigPep-
Yes
sequence


PR:000000286 latent TGF-beta-binding protein 1 isoform 2, LTBP1/iso:2

organism-sequence


PR:Q14766-2 latent-transforming growth factor beta-binding protein 1 isoform Short (human), hLTBP1/iso:Short

organism-modification


PR:000036461 latent TGF-beta-binding protein 1 isoform 2, signal peptide removed form (human), hLTBP1/iso:2/SigPep-
Yes
organism-sequence


PR:Q8CG19-2 latent-transforming growth factor beta-binding protein 1 isoform Short (mouse), mLTBP1/iso:Short

organism-modification


PR:000036462 latent TGF-beta-binding protein 1 isoform 2, signal peptide removed form (mouse), mLTBP1/iso:2/SigPep-
Yes
modification


PR:000000552 latent TGF-beta-binding protein 1 isoform 2, signal peptide removed form, LTBP1/iso:2/SigPep-

organism-modification


PR:000036461 latent TGF-beta-binding protein 1 isoform 2, signal peptide removed form (human), hLTBP1/iso:2/SigPep-
Yes
organism-modification


PR:000036462 latent TGF-beta-binding protein 1 isoform 2, signal peptide removed form (mouse), mLTBP1/iso:2/SigPep-
Yes
modification


PR:000025430 latent TGF-beta-binding protein 1 proteolytic cleavage product, LTBP1/ClvPrd

gene


PR:000009973 latent-transforming growth factor beta-binding protein 2, LTBP2

organism-gene


PR:O08999 latent-transforming growth factor beta-binding protein 2 (mouse), mLTBP2

organism-gene


PR:O35806 latent-transforming growth factor beta-binding protein 2 (rat), rLTBP2

organism-gene


PR:Q14767 latent-transforming growth factor beta-binding protein 2 (human), hLTBP2

organism-modification


PR:000048268 latent-transforming growth factor beta-binding protein 2, signal peptide removed form (human), hLTBP2/SigPep-

organism-modification


PR:000057255 latent-transforming growth factor beta-binding protein 2 O-glycosylated 1 (human), hLTBP2/OGlyco:1

organism-modification


PR:000057256 latent-transforming growth factor beta-binding protein 2 O-glycosylated 2 (human), hLTBP2/OGlyco:2

organism-modification


PR:000057257 latent-transforming growth factor beta-binding protein 2 O-glycosylated 3 (human), hLTBP2/OGlyco:3

organism-modification


PR:000057258 latent-transforming growth factor beta-binding protein 2 O-glycosylated 4 (human), hLTBP2/OGlyco:4

organism-modification


PR:000057259 latent-transforming growth factor beta-binding protein 2 O-glycosylated 5 (human), hLTBP2/OGlyco:5

organism-modification


PR:000057260 latent-transforming growth factor beta-binding protein 2 O-glycosylated 6 (human), hLTBP2/OGlyco:6

organism-modification


PR:000057261 latent-transforming growth factor beta-binding protein 2 O-glycosylated 7 (human), hLTBP2/OGlyco:7

organism-modification


PR:000057262 latent-transforming growth factor beta-binding protein 2 O-glycosylated 8 (human), hLTBP2/OGlyco:8

organism-modification


PR:000057263 latent-transforming growth factor beta-binding protein 2 O-glycosylated 9 (human), hLTBP2/OGlyco:9

organism-modification


PR:000057264 latent-transforming growth factor beta-binding protein 2 O-glycosylated 10 (human), hLTBP2/OGlyco:10

organism-modification


PR:000057265 latent-transforming growth factor beta-binding protein 2 O-glycosylated 11 (human), hLTBP2/OGlyco:11

organism-modification


PR:000057266 latent-transforming growth factor beta-binding protein 2 O-glycosylated 12 (human), hLTBP2/OGlyco:12

organism-modification


PR:000057267 latent-transforming growth factor beta-binding protein 2 O-glycosylated 13 (human), hLTBP2/OGlyco:13

organism-modification


PR:000057268 latent-transforming growth factor beta-binding protein 2 O-glycosylated 14 (human), hLTBP2/OGlyco:14

organism-modification


PR:000057269 latent-transforming growth factor beta-binding protein 2 O-glycosylated 15 (human), hLTBP2/OGlyco:15

organism-modification


PR:000057270 latent-transforming growth factor beta-binding protein 2 O-glycosylated 16 (human), hLTBP2/OGlyco:16

organism-modification


PR:000057271 latent-transforming growth factor beta-binding protein 2 O-glycosylated 17 (human), hLTBP2/OGlyco:17

organism-modification


PR:000057272 latent-transforming growth factor beta-binding protein 2 O-glycosylated 18 (human), hLTBP2/OGlyco:18

organism-modification


PR:000057273 latent-transforming growth factor beta-binding protein 2 O-glycosylated 19 (human), hLTBP2/OGlyco:19

organism-modification


PR:000057274 latent-transforming growth factor beta-binding protein 2 O-glycosylated 20 (human), hLTBP2/OGlyco:20

organism-modification


PR:000057275 latent-transforming growth factor beta-binding protein 2 O-glycosylated 21 (human), hLTBP2/OGlyco:21

organism-modification


PR:000057276 latent-transforming growth factor beta-binding protein 2 O-glycosylated 22 (human), hLTBP2/OGlyco:22

organism-modification


PR:000057277 latent-transforming growth factor beta-binding protein 2 O-glycosylated 23 (human), hLTBP2/OGlyco:23

organism-modification


PR:000057278 latent-transforming growth factor beta-binding protein 2 O-glycosylated 24 (human), hLTBP2/OGlyco:24

organism-modification


PR:000057279 latent-transforming growth factor beta-binding protein 2 O-glycosylated 25 (human), hLTBP2/OGlyco:25

organism-modification


PR:000057280 latent-transforming growth factor beta-binding protein 2 O-glycosylated 26 (human), hLTBP2/OGlyco:26

organism-modification


PR:000057281 latent-transforming growth factor beta-binding protein 2 O-glycosylated 27 (human), hLTBP2/OGlyco:27

organism-modification


PR:000057282 latent-transforming growth factor beta-binding protein 2 O-glycosylated 28 (human), hLTBP2/OGlyco:28

organism-modification


PR:000057283 latent-transforming growth factor beta-binding protein 2 O-glycosylated 29 (human), hLTBP2/OGlyco:29

organism-modification


PR:000057284 latent-transforming growth factor beta-binding protein 2 O-glycosylated 30 (human), hLTBP2/OGlyco:30

organism-modification


PR:000057285 latent-transforming growth factor beta-binding protein 2 O-glycosylated 31 (human), hLTBP2/OGlyco:31

organism-modification


PR:000057286 latent-transforming growth factor beta-binding protein 2 O-glycosylated 32 (human), hLTBP2/OGlyco:32

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000018 IFNG

"A protein that is similar in overall domain structure to fibrillins that is mainly composed of two types of repeated protein domains, namely epidermal growth factor (EGF-like) and TB (8-Cys-like repeats). The latent TGF-beta-binding protein is characterized by having four of the TB domains." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PIRSF:PIRSF037569
enablesGO:0019838 growth factor binding with PR:000000046 transforming growth factor beta PIRSF:PIRSF037569
PR:000036461 hLTBP1/iso:2/SigPep-
UniProtKB:Q14766-2, 21-1395
"A latent TGF-beta-binding protein 1 isoform 2, signal peptide removed form in human. UniProtKB:Q14766-2, 21-1395." [PMID:10930463, PMID:11104663, PRO:CNA]		 enablesGO:0005515 protein binding with PR:000000617 LAP PMID:10930463
located_inGO:0032991 protein-containing complex PMID:10930463; PMID:11104663
PR:000036462 mLTBP1/iso:2/SigPep-
UniProtKB:Q8CG19-2, 20-1394
"A latent TGF-beta-binding protein 1 isoform 2, signal peptide removed form in mouse. UniProtKB:Q8CG19-2, 20-1394." [PMID:11104663, PMID:7730318, PMID:9008713, PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11104663; PMID:7730318
located_inGO:0005615 extracellular space PMID:9008713
PR:000036463 hLTBP1/iso:1/SigPep-
UniProtKB:Q14766-1, 24-1721
"A latent TGF-beta-binding protein 1 isoform 1, signal peptide removed form in human. UniProtKB:Q14766-1, 24-1721." [PMID:8537398, PRO:CNA, PRO:DAN]		 enablesGO:0005024 transforming growth factor beta receptor activity PMID:8537398
located_inGO:0031012 extracellular matrix PMID:8537398
PR:Q14766-1 hLTBP1/iso:Long
latent-transforming growth factor beta-binding protein 1 isoform LTBP-1L (human)
"A latent TGF-beta-binding protein 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 enablesGO:0005024 transforming growth factor beta receptor activity PMID:8537398
located_inGO:0031012 extracellular matrix PMID:8537398