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Protein Ontology report - smad3
PR:000000365 - http://purl.obolibrary.org/obo/PR_000000365
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000365   
  PRO namesmad3 
  Synonyms
PRO-Short-label: EXACT:SMAD3
Gene-based: RELATED:MADH3
Other: EXACT:JV15-2 | MAD homolog 3 | MAD-3 | mad3 | mothers against DPP homolog 3 | SMAD 3 | SMAD family member 3
  Definition"A TGF-beta receptor-regulated smad protein that is a translation product of the human SMAD3 gene or a 1:1 ortholog thereof." [PMID:9311995] 
  PRO Categorygene 
  ParentPR:000000066 TGF-beta receptor-regulated smad protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 7                                        
         Modification6                                                  Organism-Modification 18                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000365 smad3, SMAD3

organism-gene


PR:P84022 mothers against decapentaplegic homolog 3 (human), hSMAD3

organism-sequence


PR:000062539 mothers against decapentaplegic homolog 3 sequence variant S425F (human), hSMAD3/var:S425F

organism-sequence


PR:000063486 mothers against decapentaplegic homolog 3 sequence variant S425C (human), hSMAD3/var:S425C

organism-sequence


PR:P84022-1 mothers against decapentaplegic homolog 3 isoform 1 (human), hSMAD3/iso:1
Yes
organism-modification


PR:000026333 smad3 isoform 1 phosphorylated 1 (human), hSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036557 smad3 isoform 1 acetylated and phosphorylated 1 (human), hSMAD3/iso:1/AcPhos:1
Yes
organism-sequence


PR:P84022-2 mothers against decapentaplegic homolog 3 isoform h2 (human), hSMAD3/iso:h2

organism-sequence


PR:P84022-3 mothers against decapentaplegic homolog 3 isoform h3 (human), hSMAD3/iso:h3

organism-sequence


PR:P84022-4 mothers against decapentaplegic homolog 3 isoform h4 (human), hSMAD3/iso:h4

organism-modification


PR:000049285 mothers against decapentaplegic homolog 3 phosphorylated 1 (human), hSMAD3/Phos:1

organism-modification


PR:000049286 mothers against decapentaplegic homolog 3 phosphorylated 2 (human), hSMAD3/Phos:2

organism-modification


PR:000049287 mothers against decapentaplegic homolog 3 ubiquitinated form (human), hSMAD3/UbiqLys+

organism-modification


PR:000064859 mothers against decapentaplegic homolog 3 phosphorylated and ubiquitinated 1 (human), hSMAD3/PhosUbiq:1

organism-modification


PR:000060563 mothers against decapentaplegic homolog 3 sequence variant R268H phosphorylated 1 (human), hSMAD3/var:R268H/Phos:1

organism-modification


PR:000061858 mothers against decapentaplegic homolog 3 ADP-ribosylated and phosphorylated 1 (human), hSMAD3/ADPribPhos:1

organism-modification


PR:000063368 mothers against decapentaplegic homolog 3 phosphorylated 3 (human), hSMAD3/Phos:3

organism-modification


PR:000063580 mothers against decapentaplegic homolog 3 sequence variant R268C phosphorylated 1 (human), hSMAD3/var:R268C/Phos:1

organism-modification


PR:000063639 mothers against decapentaplegic homolog 3 sequence variant D258N phosphorylated 1 (human), hSMAD3/var:D258N/Phos:1

organism-modification


PR:000065228 mothers against decapentaplegic homolog 3 deaminated 1 (human), hSMAD3/Deam:1

organism-modification


PR:000065534 mothers against decapentaplegic homolog 3 methylated 1 (human), hSMAD3/Me:1

organism-modification


PR:000073148 mothers against decapentaplegic homolog 3 cysteinylated 1 (human), hSMAD3/Cyst:1

organism-modification


PR:000074741 mothers against decapentaplegic homolog 3 methylated 2 (human), hSMAD3/Me:2

organism-gene


PR:P84023 mothers against decapentaplegic homolog 3 (chicken), chick-SMAD3

organism-gene


PR:P84025 mothers against decapentaplegic homolog 3 (rat), rSMAD3

organism-gene


PR:Q8BUN5 mothers against decapentaplegic homolog 3 (mouse), mSMAD3

organism-sequence


PR:Q8BUN5-1 mothers against decapentaplegic homolog 3 isoform 1 (mouse), mSMAD3/iso:1
Yes
organism-modification


PR:000036558 smad3 isoform 1 phosphorylated 1 (mouse), mSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036560 smad3 isoform 1 phosphorylated 2 (mouse), mSMAD3/iso:1/Phos:2
Yes
organism-modification


PR:000036561 smad3 isoform 1 phosphorylated 3 (mouse), mSMAD3/iso:1/Phos:3
Yes
sequence


PR:000000475 smad3 isoform 1, SMAD3/iso:1

organism-sequence


PR:P84022-1 mothers against decapentaplegic homolog 3 isoform 1 (human), hSMAD3/iso:1
Yes
organism-modification


PR:000026333 smad3 isoform 1 phosphorylated 1 (human), hSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036557 smad3 isoform 1 acetylated and phosphorylated 1 (human), hSMAD3/iso:1/AcPhos:1
Yes
organism-sequence


PR:Q8BUN5-1 mothers against decapentaplegic homolog 3 isoform 1 (mouse), mSMAD3/iso:1
Yes
organism-modification


PR:000036558 smad3 isoform 1 phosphorylated 1 (mouse), mSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036560 smad3 isoform 1 phosphorylated 2 (mouse), mSMAD3/iso:1/Phos:2
Yes
organism-modification


PR:000036561 smad3 isoform 1 phosphorylated 3 (mouse), mSMAD3/iso:1/Phos:3
Yes
modification


PR:000000577 smad3 isoform 1 acetylated and phosphorylated form, SMAD3/iso:1/AcPhos+

modification


PR:000000657 smad3 isoform 1 acetylated and phosphorylated 1, SMAD3/iso:1/AcPhos:1

organism-modification


PR:000036557 smad3 isoform 1 acetylated and phosphorylated 1 (human), hSMAD3/iso:1/AcPhos:1
Yes
modification


PR:000000578 smad3 isoform 1 phosphorylated form, SMAD3/iso:1/PhosRes+

modification


PR:000000577 smad3 isoform 1 acetylated and phosphorylated form, SMAD3/iso:1/AcPhos+

modification


PR:000000657 smad3 isoform 1 acetylated and phosphorylated 1, SMAD3/iso:1/AcPhos:1

organism-modification


PR:000036557 smad3 isoform 1 acetylated and phosphorylated 1 (human), hSMAD3/iso:1/AcPhos:1
Yes
modification


PR:000000658 smad3 isoform 1 phosphorylated 1, SMAD3/iso:1/Phos:1

organism-modification


PR:000026333 smad3 isoform 1 phosphorylated 1 (human), hSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036558 smad3 isoform 1 phosphorylated 1 (mouse), mSMAD3/iso:1/Phos:1
Yes
modification


PR:000000659 smad3 isoform 1 phosphorylated 2, SMAD3/iso:1/Phos:2

organism-modification


PR:000036560 smad3 isoform 1 phosphorylated 2 (mouse), mSMAD3/iso:1/Phos:2
Yes
modification


PR:000000660 smad3 isoform 1 phosphorylated 3, SMAD3/iso:1/Phos:3

organism-modification


PR:000036561 smad3 isoform 1 phosphorylated 3 (mouse), mSMAD3/iso:1/Phos:3
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026333 hSMAD3/iso:1/Phos:1
UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046
"A smad3 isoform 1 phosphorylated 1 in human. UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046." [PRO:DNx, UniProtKB:P84022]		 acts_upstream_of_or_withinGO:0006366 transcription by RNA polymerase II PMID:10823886
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8774881; PMID:9380693
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10823886; PMID:12943993
GO:0008134 transcription factor binding PMID:15084259
GO:0046332 SMAD binding PMID:15350224; PMID:9311995
located_inGO:0005634 nucleus PMID:10846168; PMID:15280432
GO:0005667 transcription factor complex PMID:12374795
PR:000036557 hSMAD3/iso:1/AcPhos:1
UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046
"A smad3 isoform 1 acetylated and phosphorylated 1 in human. UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756, PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17074756
enablesGO:0003700 DNA-binding transcription factor activity PMID:17074756
located_inGO:0005634 nucleus PMID:17074756
PR:000036558 mSMAD3/iso:1/Phos:1
UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046
"A smad3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046." [PMID:10823886, PMID:12943993, PMID:15282343, PMID:15464984, PMID:9702197, PRO:CNA]		 enablesGO:0003690 double-stranded DNA binding PMID:15282343
GO:0003700 DNA-binding transcription factor activity PMID:10823886; PMID:12943993
GO:0008134 transcription factor binding PMID:15464984; PMID:9702197
located_inGO:0005634 nucleus PMID:12943993; PMID:15282343
GO:0005667 transcription factor complex PMID:9702197
PR:000036560 mSMAD3/iso:1/Phos:2
UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046
"A smad3 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN]		 enablesdecreased GO:0003700 DNA-binding transcription factor activity relative to PR:000036558 mSMAD3/iso:1/Phos:1 PMID:15241418
PR:000036561 mSMAD3/iso:1/Phos:3
UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046
"A smad3 isoform 1 phosphorylated 3 in mouse. UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046." [PMID:10197981, PRO:CNA, PRO:DAN]		 enablesNOT GO:0003713 transcription coactivator activity PMID:10197981
located_inGO:0005737 cytoplasm PMID:10197981
PR:P84022-1 hSMAD3/iso:1

"A smad3 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:8774881
enablesGO:0005515 protein binding with PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:12154125
GO:0005515 protein binding with PR:O95405-1 PMID:12154125
located_inGO:0005737 cytoplasm PMID:17074053
PR:Q8BUN5-1 mSMAD3/iso:1

"A smad3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12543979
enablesGO:0005515 protein binding with PR:000036434 mTGFBR1/iso:1/SigPep-/Phos:1 PMID:12154125
GO:0005515 protein binding with PR:A2A8R0 mZFYVE9/iso:1 PMID:12154125