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Protein Ontology report - interleukin-17
PR:000001092 - http://purl.obolibrary.org/obo/PR_000001092
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000001092   
  PRO nameinterleukin-17 
  Synonyms
PRO-Short-label: EXACT:fam:IL-17
Other: EXACT:IL17
  Definition"A protein that is a T cell-derived cytokine that may play an important role in the initiation or maintenance of the proinflammatory response. Except for IL-17B, all other IL-17 family members are homodimers containing five highly conserved cysteine residues forming characteristic cystein-knot structure, similar to that found in the TGF-beta-like cystine-knot (PR:000000008). This class consists of six cytokines. Among them, interleukin 17A (IL-17) and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play a critical role in inflammation and autoimmunity. On the other hand, IL-17E, also called IL-25, has been associated with allergic responses." [PMID:17982105, PMID:18280574] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene6                                                  Organism-Gene 14                                        
         Sequence1                                                  Organism-Sequence 6                                        
         Modification4                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF003430
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000001092 interleukin-17, fam:IL-17
Yes
gene


PR:000001113 interleukin-25, IL25

organism-gene


PR:Q8VHH8 interleukin-25 (mouse), mIL25

organism-gene


PR:Q9H293 interleukin-25 (human), hIL25

organism-sequence


PR:Q9H293-1 interleukin-25 isoform h1 (human), hIL25/iso:h1

organism-sequence


PR:Q9H293-2 interleukin-25 isoform h2 (human), hIL25/iso:h2

organism-modification


PR:000048012 interleukin-25, signal peptide removed form (human), hIL25/SigPep-

modification


PR:000018341 interleukin-25, signal peptide removed form, IL25/SigPep-

organism-modification


PR:000048012 interleukin-25, signal peptide removed form (human), hIL25/SigPep-

gene


PR:000001138 interleukin-17A, IL17A

organism-gene


PR:Q16552 interleukin-17A (human), hIL17A

organism-modification


PR:000036602 interleukin-17A, signal peptide removed form (human), hIL17A/SigPep-
Yes
Yes
organism-gene


PR:Q5TKT0 interleukin 17_5 (zebrafish), z-IL17A

organism-gene


PR:Q61453 interleukin-17A (rat), rIL17A

organism-gene


PR:Q62386 interleukin-17A (mouse), mIL17A

modification


PR:000018349 interleukin-17A, signal peptide removed form, IL17A/SigPep-

organism-modification


PR:000036602 interleukin-17A, signal peptide removed form (human), hIL17A/SigPep-
Yes
Yes
modification


PR:000025428 interleukin-17A proteolytic cleavage product, IL17A/ClvPrd

gene


PR:000001139 interleukin-17B, IL17B

organism-gene


PR:Q9QXT6 interleukin-17B (mouse), mIL17B

organism-sequence


PR:Q9QXT6-1 interleukin-17B isoform 1 (mouse), mIL17B/iso:1

organism-gene


PR:Q9UHF5 interleukin-17B (human), hIL17B

organism-sequence


PR:Q9UHF5-1 interleukin-17B isoform 1 (human), hIL17B/iso:1

sequence


PR:000043889 interleukin-17B isoform 1, IL17B/iso:1

organism-sequence


PR:Q9QXT6-1 interleukin-17B isoform 1 (mouse), mIL17B/iso:1

organism-sequence


PR:Q9UHF5-1 interleukin-17B isoform 1 (human), hIL17B/iso:1

gene


PR:000001140 interleukin-17C, IL17C

organism-gene


PR:Q8K4C5 interleukin-17C (mouse), mIL17C

organism-gene


PR:Q9P0M4 interleukin-17C (human), hIL17C

organism-modification


PR:000047989 interleukin-17C, signal peptide removed form (human), hIL17C/SigPep-

gene


PR:000001141 interleukin-17D, IL17D

organism-gene


PR:Q8TAD2 interleukin-17D (human), hIL17D

gene


PR:000001142 interleukin-17F, IL17F

organism-gene


PR:Q5BJ95 interleukin-17F (rat), rIL17F

organism-gene


PR:Q7TNI7 interleukin-17F (mouse), mIL17F

organism-sequence


PR:Q7TNI7-1 interleukin-17F isoform m1 (mouse), mIL17F/iso:m1

organism-sequence


PR:Q7TNI7-2 interleukin-17F isoform m2 (mouse), mIL17F/iso:m2

organism-gene


PR:Q96PD4 interleukin-17F (human), hIL17F

organism-modification


PR:000044527 interleukin-17F, signal peptide removed form (human), hIL17F/SigPep-

Yes
modification


PR:000018351 interleukin-17F, signal peptide removed form, IL17F/SigPep-

organism-modification


PR:000044527 interleukin-17F, signal peptide removed form (human), hIL17F/SigPep-

Yes
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fam:IL-17 forms found in complexes   

fam:IL-17 Component
 Complexes
PR:000036602 hIL17A/SigPep- PR:000044528 interleukin 17F/17A heterodimer (human)
PR:000044530 interleukin 17A homodimer (human)
PR:000044527 hIL17F/SigPep- PR:000044528 interleukin 17F/17A heterodimer (human)
PR:000044529 interleukin 17F homodimer (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000001092 fam:IL-17
IL17
"A protein that is a T cell-derived cytokine that may play an important role in the initiation or maintenance of the proinflammatory response. Except for IL-17B, all other IL-17 family members are homodimers containing five highly conserved cysteine residues forming characteristic cystein-knot structure, similar to that found in the TGF-beta-like cystine-knot (PR:000000008). This class consists of six cytokines. Among them, interleukin 17A (IL-17) and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play a critical role in inflammation and autoimmunity. On the other hand, IL-17E, also called IL-25, has been associated with allergic responses." [PMID:17982105, PMID:18280574]		 acts_upstream_of_or_withinGO:0019221 cytokine-mediated signaling pathway PIRSF:PIRSF003430
PR:000036602 hIL17A/SigPep-
UniProtKB:Q16552, 24-155 | PRO_0000015423
"An interleukin-17A, signal peptide removed form in human. UniProtKB:Q16552, 24-155." [PMID:15055556, PMID:15340161, PMID:7499828, PRO:CNA]		 enablesGO:0005125 cytokine activity PMID:7499828
GO:0042803 protein homodimerization activity PMID:15055556
located_inGO:0005615 extracellular space PMID:15340161; PMID:7499828