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Protein Ontology report - voltage-gated sodium channel subunit alpha
PR:000001975 - http://purl.obolibrary.org/obo/PR_000001975
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001975   
  PRO namevoltage-gated sodium channel subunit alpha 
  Definition"A voltage-gated sodium channel protein that has a core architecture consisting of four similar domains (I-VI), each containing six transmembrane helices (S1-S6), with a pore loop between S5 and S6. The S4 segments contain positively charged amino acids at every third position and serve as voltage sensors. These large proteins (about 2000 amino acids) contain a unique Sodium ion transport-associated domain (Pfam:PF06512) located between two pairs of Ion transport protein domains (Pfam:PF00520). An IQ calmodulin-binding motif (Pfam:PF00612) may be found about 100 amino acids from the carboxyl end." [PRO:WCB] 
  PRO Categoryfamily 
  ParentPR:000044660 voltage-gated sodium channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene11                                                  Organism-Gene 32                                        
         Sequence27                                                  Organism-Sequence 64                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF002448
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000001975 voltage-gated sodium channel subunit alpha, CACNA1I

gene


PR:000002095 sodium channel protein type 1 subunit alpha, SCN1A

organism-gene


PR:A2APX8 sodium channel protein type 1 subunit alpha (mouse), mSCN1A

organism-sequence


PR:A2APX8-1 sodium channel protein type 1 subunit alpha isoform m1 (mouse), mSCN1A/iso:m1

organism-sequence


PR:A2APX8-2 sodium channel protein type 1 subunit alpha isoform m2 (mouse), mSCN1A/iso:m2

organism-sequence


PR:A2APX8-3 sodium channel protein type 1 subunit alpha isoform m3 (mouse), mSCN1A/iso:m3

organism-gene


PR:P04774 sodium channel protein type 1 subunit alpha (rat), rSCN1A

organism-sequence


PR:P04774-1 sodium channel protein type 1 subunit alpha isoform 1 (rat), rSCN1A/iso:1

organism-gene


PR:P35498 sodium channel protein type 1 subunit alpha (human), hSCN1A

organism-sequence


PR:P35498-1 sodium channel protein type 1 subunit alpha isoform 1 (human), hSCN1A/iso:1

organism-sequence


PR:P35498-2 sodium channel protein type 1 subunit alpha isoform h2 (human), hSCN1A/iso:h2

organism-sequence


PR:P35498-3 sodium channel protein type 1 subunit alpha isoform h3 (human), hSCN1A/iso:h3

sequence


PR:000039339 sodium channel protein type 1 subunit alpha isoform 1, SCN1A/iso:1

organism-sequence


PR:P04774-1 sodium channel protein type 1 subunit alpha isoform 1 (rat), rSCN1A/iso:1

organism-sequence


PR:P35498-1 sodium channel protein type 1 subunit alpha isoform 1 (human), hSCN1A/iso:1

gene


PR:000002096 sodium channel protein type 10 subunit alpha, SCN10A

organism-gene


PR:Q62968 sodium channel protein type 10 subunit alpha (rat), rSCN10A

organism-sequence


PR:Q62968-1 sodium channel protein type 10 subunit alpha isoform r1 (rat), rSCN10A/iso:r1

organism-sequence


PR:Q62968-2 sodium channel protein type 10 subunit alpha isoform r2 (rat), rSCN10A/iso:r2

organism-gene


PR:Q6QIY3 sodium channel protein type 10 subunit alpha (mouse), mSCN10A

organism-sequence


PR:Q6QIY3-1 sodium channel protein type 10 subunit alpha isoform m1 (mouse), mSCN10A/iso:m1

organism-sequence


PR:Q6QIY3-2 sodium channel protein type 10 subunit alpha isoform m2 (mouse), mSCN10A/iso:m2

organism-sequence


PR:Q6QIY3-3 sodium channel protein type 10 subunit alpha isoform m3 (mouse), mSCN10A/iso:m3

organism-gene


PR:Q9Y5Y9 sodium channel protein type 10 subunit alpha (human), hSCN10A

gene


PR:000002097 sodium channel protein type 11 subunit alpha, SCN11A

organism-gene


PR:O88457 sodium channel protein type 11 subunit alpha (rat), rSCN11A

organism-gene


PR:Q9R053 sodium channel protein type 11 subunit alpha (mouse), mSCN11A

organism-gene


PR:Q9UI33 sodium channel protein type 11 subunit alpha (human), hSCN11A

organism-sequence


PR:Q9UI33-1 sodium channel protein type 11 subunit alpha isoform h1 (human), hSCN11A/iso:h1

organism-sequence


PR:Q9UI33-2 sodium channel protein type 11 subunit alpha isoform h2 (human), hSCN11A/iso:h2

organism-sequence


PR:Q9UI33-3 sodium channel protein type 11 subunit alpha isoform h3 (human), hSCN11A/iso:h3

organism-gene


PR:Q9W0Y8 sodium channel protein 60E (fruit fly), fly-SCN11A

organism-sequence


PR:Q9W0Y8-1 sodium channel protein 60E isoform G (fruit fly), fly-SCN11A/iso:G

organism-sequence


PR:Q9W0Y8-3 sodium channel protein 60E isoform P (fruit fly), fly-SCN11A/iso:P

gene


PR:000002098 sodium channel protein type 2 subunit alpha, SCN2A

organism-gene


PR:B1AWN6 sodium channel protein type 2 subunit alpha (mouse), mSCN2A

organism-gene


PR:E1BQT2 sodium channel protein (chicken), chick-SCN2A

organism-gene


PR:P04775 sodium channel protein type 2 subunit alpha (rat), rSCN2A

organism-gene


PR:Q99250 sodium channel protein type 2 subunit alpha (human), hSCN2A

organism-sequence


PR:Q99250-1 sodium channel protein type 2 subunit alpha isoform h1 (human), hSCN2A/iso:h1

organism-sequence


PR:Q99250-2 sodium channel protein type 2 subunit alpha isoform h2 (human), hSCN2A/iso:h2

gene


PR:000002099 sodium channel protein type 3 subunit alpha, SCN3A

organism-gene


PR:A2ASI5 sodium channel protein type 3 subunit alpha (mouse), mSCN3A

organism-sequence


PR:A2ASI5-1 sodium channel protein type 3 subunit alpha isoform m1 (mouse), mSCN3A/iso:m1

organism-sequence


PR:A2ASI5-2 sodium channel protein type 3 subunit alpha isoform m2 (mouse), mSCN3A/iso:m2

organism-sequence


PR:A2ASI5-3 sodium channel protein type 3 subunit alpha isoform m3 (mouse), mSCN3A/iso:m3

organism-gene


PR:P08104 sodium channel protein type 3 subunit alpha (rat), rSCN3A

organism-sequence


PR:P08104-1 sodium channel protein type 3 subunit alpha isoform 1 (rat), rSCN3A/iso:1

organism-gene


PR:Q9NY46 sodium channel protein type 3 subunit alpha (human), hSCN3A

organism-sequence


PR:Q9NY46-1 sodium channel protein type 3 subunit alpha isoform h1 (human), hSCN3A/iso:h1

organism-sequence


PR:Q9NY46-2 sodium channel protein type 3 subunit alpha isoform h2 (human), hSCN3A/iso:h2

organism-sequence


PR:Q9NY46-3 sodium channel protein type 3 subunit alpha isoform h3 (human), hSCN3A/iso:h3

organism-sequence


PR:Q9NY46-4 sodium channel protein type 3 subunit alpha isoform 4 (human), hSCN3A/iso:4

sequence


PR:000043650 sodium channel protein type 3 subunit alpha isoform 4, SCN3A/iso:4

organism-sequence


PR:P08104-1 sodium channel protein type 3 subunit alpha isoform 1 (rat), rSCN3A/iso:1

organism-sequence


PR:Q9NY46-4 sodium channel protein type 3 subunit alpha isoform 4 (human), hSCN3A/iso:4

gene


PR:000002100 sodium channel protein type 4 subunit alpha, SCN4A

organism-gene


PR:P15390 sodium channel protein type 4 subunit alpha (rat), rSCN4A

organism-gene


PR:P35499 sodium channel protein type 4 subunit alpha (human), hSCN4A

organism-modification


PR:000056393 sodium channel protein type 4 subunit alpha N-glycosylated 1 (human), hSCN4A/NGlyco:1

organism-modification


PR:000067684 sodium channel protein type 4 subunit alpha deaminated 1 (human), hSCN4A/Deam:1

organism-modification


PR:000081649 sodium channel protein type 4 subunit alpha deaminated 2 (human), hSCN4A/Deam:2

organism-gene


PR:Q9ER60 sodium channel protein type 4 subunit alpha (mouse), mSCN4A

gene


PR:000002101 sodium channel protein type 5 subunit alpha, SCN5A

organism-gene


PR:P15389 sodium channel protein type 5 subunit alpha (rat), rSCN5A

organism-sequence


PR:P15389-1 sodium channel protein type 5 subunit alpha isoform r1 (rat), rSCN5A/iso:r1

organism-sequence


PR:P15389-2 sodium channel protein type 5 subunit alpha isoform r2 (rat), rSCN5A/iso:r2

organism-gene


PR:Q14524 sodium channel protein type 5 subunit alpha (human), hSCN5A

organism-sequence


PR:Q14524-1 sodium channel protein type 5 subunit alpha isoform h1 (human), hSCN5A/iso:h1

organism-sequence


PR:Q14524-2 sodium channel protein type 5 subunit alpha isoform h2 (human), hSCN5A/iso:h2

organism-sequence


PR:Q14524-3 sodium channel protein type 5 subunit alpha isoform h3 (human), hSCN5A/iso:h3

organism-sequence


PR:Q14524-4 sodium channel protein type 5 subunit alpha isoform h4 (human), hSCN5A/iso:h4

organism-sequence


PR:Q14524-5 sodium channel protein type 5 subunit alpha isoform h5 (human), hSCN5A/iso:h5

organism-sequence


PR:Q14524-6 sodium channel protein type 5 subunit alpha isoform h6 (human), hSCN5A/iso:h6

organism-gene


PR:Q9JJV9 sodium channel protein type 5 subunit alpha (mouse), mSCN5A

organism-sequence


PR:Q9JJV9-1 sodium channel protein type 5 subunit alpha isoform 1 (mouse), mScn5a/iso:1
Yes
organism-sequence


PR:Q9JJV9-2 sodium channel protein type 5 subunit alpha isoform m2 (mouse), mSCN5A/iso:m2

organism-modification


PR:000049831 sodium channel protein type 5 subunit alpha phosphorylated 1 (mouse), mScn5a/Phos:1

organism-modification


PR:000049832 sodium channel protein type 5 subunit alpha unphosphorylated 1 (mouse), mScn5a/UnPhos:1

gene


PR:000002102 sodium channel protein type 7 subunit alpha, SCN7A

organism-gene


PR:Q01118 sodium channel protein type 7 subunit alpha (human), hSCN7A

gene


PR:000002103 sodium channel protein type 8 subunit alpha, SCN8A

organism-gene


PR:O88420 sodium channel protein type 8 subunit alpha (rat), rSCN8A

organism-sequence


PR:O88420-1 sodium channel protein type 8 subunit alpha isoform r1 (rat), rSCN8A/iso:r1

organism-sequence


PR:O88420-2 sodium channel protein type 8 subunit alpha isoform 2 (rat), rSCN8A/iso:2

organism-gene


PR:Q9UQD0 sodium channel protein type 8 subunit alpha (human), hSCN8A

organism-sequence


PR:Q9UQD0-1 sodium channel protein type 8 subunit alpha isoform h1 (human), hSCN8A/iso:h1

organism-sequence


PR:Q9UQD0-2 sodium channel protein type 8 subunit alpha isoform h2 (human), hSCN8A/iso:h2

organism-sequence


PR:Q9UQD0-3 sodium channel protein type 8 subunit alpha isoform h3 (human), hSCN8A/iso:h3

organism-sequence


PR:Q9UQD0-4 sodium channel protein type 8 subunit alpha isoform h4 (human), hSCN8A/iso:h4

organism-sequence


PR:Q9UQD0-5 sodium channel protein type 8 subunit alpha isoform h5 (human), hSCN8A/iso:h5

organism-modification


PR:000073611 sodium channel protein type 8 subunit alpha deaminated 1 (human), hSCN8A/Deam:1

organism-gene


PR:Q9WTU3 sodium channel protein type 8 subunit alpha (mouse), mSCN8A

organism-sequence


PR:Q9WTU3-1 sodium channel protein type 8 subunit alpha isoform m1 (mouse), mSCN8A/iso:m1

organism-sequence


PR:Q9WTU3-2 sodium channel protein type 8 subunit alpha isoform m2 (mouse), mSCN8A/iso:m2

organism-sequence


PR:Q9WTU3-3 sodium channel protein type 8 subunit alpha isoform 3 (mouse), mSCN8A/iso:3

organism-sequence


PR:Q9WTU3-4 sodium channel protein type 8 subunit alpha isoform m4 (mouse), mSCN8A/iso:m4

organism-sequence


PR:Q9WTU3-5 sodium channel protein type 8 subunit alpha isoform m5 (mouse), mSCN8A/iso:m5

sequence


PR:000044069 sodium channel protein type 8 subunit alpha isoform 3, SCN8A/iso:3

organism-sequence


PR:O88420-2 sodium channel protein type 8 subunit alpha isoform 2 (rat), rSCN8A/iso:2

organism-sequence


PR:Q9WTU3-3 sodium channel protein type 8 subunit alpha isoform 3 (mouse), mSCN8A/iso:3

gene


PR:000002104 sodium channel protein type 9 subunit alpha, SCN9A

organism-gene


PR:O08562 sodium channel protein type 9 subunit alpha (rat), rSCN9A

organism-sequence


PR:O08562-1 sodium channel protein type 9 subunit alpha isoform 1 (rat), rSCN9A/iso:1

organism-gene


PR:Q15858 sodium channel protein type 9 subunit alpha (human), hSCN9A

organism-sequence


PR:Q15858-1 sodium channel protein type 9 subunit alpha isoform h1 (human), hSCN9A/iso:h1

organism-sequence


PR:Q15858-2 sodium channel protein type 9 subunit alpha isoform h2 (human), hSCN9A/iso:h2

organism-sequence


PR:Q15858-3 sodium channel protein type 9 subunit alpha isoform h3 (human), hSCN9A/iso:h3

organism-sequence


PR:Q15858-4 sodium channel protein type 9 subunit alpha isoform h4 (human), hSCN9A/iso:h4

organism-gene


PR:Q62205 sodium channel protein type 9 subunit alpha (mouse), mSCN9A

organism-sequence


PR:Q62205-1 sodium channel protein type 9 subunit alpha isoform 1 (mouse), mSCN9A/iso:1

sequence


PR:000041094 sodium channel protein type 9 subunit alpha isoform 1, SCN9A/iso:1

organism-sequence


PR:O08562-1 sodium channel protein type 9 subunit alpha isoform 1 (rat), rSCN9A/iso:1

organism-sequence


PR:Q62205-1 sodium channel protein type 9 subunit alpha isoform 1 (mouse), mSCN9A/iso:1

gene


PR:000050403 sodium channel protein para, para

organism-gene


PR:P35500 sodium channel protein para (fruit fly), fly-para

organism-sequence


PR:P35500-1 sodium channel protein para isoform A (fruit fly), fly-para/iso:A

organism-sequence


PR:P35500-2 sodium channel protein para isoform D (fruit fly), fly-para/iso:D

organism-sequence


PR:P35500-3 sodium channel protein para isoform exonb (fruit fly), fly-para/iso:exonb

organism-sequence


PR:P35500-4 sodium channel protein para isoform C (fruit fly), fly-para/iso:C

organism-sequence


PR:P35500-5 sodium channel protein para isoform E (fruit fly), fly-para/iso:E

organism-sequence


PR:P35500-6 sodium channel protein para isoform F24 (fruit fly), fly-para/iso:F24

organism-sequence


PR:P35500-7 sodium channel protein para isoform F30 (fruit fly), fly-para/iso:F30

organism-sequence


PR:P35500-8 sodium channel protein para isoform B (fruit fly), fly-para/iso:B

organism-sequence


PR:P35500-9 sodium channel protein para isoform exond (fruit fly), fly-para/iso:exond

organism-gene


PR:Q94615 sodium channel protein (Musca domestica), para (MUSDO)

sequence


PR:000050404 sodium channel protein para sequence variant at position 989, para/var:not_S989

sequence


PR:000050416 Kdr S989P, para/var:S762P

sequence


PR:000050405 sodium channel protein para sequence variant at position 1011, para/var:not_I1011

sequence


PR:000050414 Kdr I1011M, para/var:I784M

sequence


PR:000050415 Kdr I1011V, para/var:I784V

sequence


PR:000050406 sodium channel protein para sequence variant at position 1014, para/var:not_L1014

sequence


PR:000050417 Kdr L1014S, para/var:L1014S

sequence


PR:000050449 Kdr L1014C, para/var:L1014C

sequence


PR:000050450 Kdr L1014F, para/var:L1014F

sequence


PR:000050407 sodium channel protein para sequence variant at position 1016, para/var:not_V1016

sequence


PR:000050412 Kdr V1016G, para/var:V1021G

sequence


PR:000050431 Kdr V1016I, para/var:V1021I

sequence


PR:000050408 sodium channel protein para sequence variant at position 1532, para/var:not_I1532

sequence


PR:000050418 Kdr I1532T, para/var:I1472T

sequence


PR:000050409 sodium channel protein para sequence variant at position 1534, para/var:not_F1534

sequence


PR:000050419 Kdr F1534C, para/var:F1318C

sequence


PR:000050426 Kdr F1534L, para/var:F1474L

sequence


PR:000050427 Kdr F1534S, para/var:F1474S

sequence


PR:000050410 sodium channel protein para sequence variant at position 1575, para/var:not_N1575

sequence


PR:000050428 Kdr N1575Y, para/var:N1515Y

sequence


PR:000050411 sodium channel protein para sequence variant at position 1763, para/var:not_D1763

sequence


PR:000050429 Kdr D1763Y, para/var:D1763Y

sequence


PR:000050430 insecticide resistant sodium channel protein para, para/kdr

sequence


PR:000050412 Kdr V1016G, para/var:V1021G

sequence


PR:000050414 Kdr I1011M, para/var:I784M

sequence


PR:000050415 Kdr I1011V, para/var:I784V

sequence


PR:000050416 Kdr S989P, para/var:S762P

sequence


PR:000050417 Kdr L1014S, para/var:L1014S

sequence


PR:000050418 Kdr I1532T, para/var:I1472T

sequence


PR:000050419 Kdr F1534C, para/var:F1318C

sequence


PR:000050426 Kdr F1534L, para/var:F1474L

sequence


PR:000050427 Kdr F1534S, para/var:F1474S

sequence


PR:000050428 Kdr N1575Y, para/var:N1515Y

sequence


PR:000050429 Kdr D1763Y, para/var:D1763Y

sequence


PR:000050431 Kdr V1016I, para/var:V1021I

sequence


PR:000050449 Kdr L1014C, para/var:L1014C

sequence


PR:000050450 Kdr L1014F, para/var:L1014F

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q9JJV9-1 mScn5a/iso:1

"A sodium channel protein type 5 subunit alpha (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJV9-1." [PRO:DNx, UniProtKB:Q9JJV9]		 acts_upstream_of_or_withinGO:0006814 sodium ion transport MGI:3623302; PMID:11834499