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Protein Ontology report - Axin-1

PR:000004526 - http://purl.obolibrary.org/obo/PR_000004526

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000004526

PRO name

Axin-1

Synonyms

PRO-Short-label:	EXACT:	AXIN1
Gene-based:	RELATED:	AXIN \| Fu
Other:	EXACT:	axis inhibition protein 1 \| protein Fused

Definition

"An Axin that is a translation product of the human AXIN1 gene or a 1:1 ortholog thereof." [PRO:DNx]

PRO Category

gene

Parent

PR:000025824 Axin

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	6
Sequence	2	Organism-Sequence	11
Modification	0	Organism-Modification	4

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?

gene

PR:000004526 Axin-1, AXIN1

organism-gene

PR:O15169 Axin-1 (human), hAXIN1

organism-sequence

PR:000060464 Axin-1 sequence variant W247* (human), hAXIN1/var:W247*

organism-sequence

PR:000061379 Axin-1 sequence variant Y346* (human), hAXIN1/var:Y346*

organism-sequence

PR:000062109 Axin-1 sequence variant E406* (human), hAXIN1/var:E406*

organism-sequence

PR:000063020 Axin-1 sequence variant L396M (human), hAXIN1/var:L396M

organism-sequence

PR:000063515 Axin-1 sequence variant E255S (human), hAXIN1/var:E255S

organism-sequence

PR:000063568 Axin-1 sequence variant R354L (human), hAXIN1/var:R354L

organism-sequence

PR:O15169-1 Axin-1 isoform 1 (human), hAXIN1/iso:1

Yes

organism-sequence

PR:O15169-2 Axin-1 isoform 2 (human), hAXIN1/iso:2

organism-modification

PR:000046442 Axin-1 ADP-ribosylated form (human), hAXIN1/ADPribRes+

organism-modification

PR:000046443 Axin-1 ADP-ribosylated and ubiquitinated form (human), hAXIN1/ADPribUbiq+

organism-modification

PR:000046443 Axin-1 ADP-ribosylated and ubiquitinated form (human), hAXIN1/ADPribUbiq+

organism-modification

PR:000046444 Axin-1 phosphorylated 1 (human), hAXIN1/Phos:1

organism-modification

PR:000046445 Axin-1 ubiquitinated 1 (human), hAXIN1/Ubiq:1

organism-gene

PR:O35625 Axin-1 (mouse), mAXIN1

organism-sequence

PR:O35625-1 Axin-1 isoform 1 (mouse), mAXIN1/iso:1

Yes

organism-sequence

PR:O35625-2 Axin-1 isoform 2 (mouse), mAXIN1/iso:2

organism-gene

PR:O42400 Axin-1 (chicken), chick-AXIN1

organism-gene

PR:O70239 Axin-1 (rat), rAXIN1

organism-sequence

PR:O70239-1 Axin-1 isoform 2 (rat), rAXIN1/iso:2

organism-gene

PR:P57094 Axin-1 (zebrafish), z-AXIN1

organism-gene

PR:Q9V407 Axin (fruit fly), fly-AXIN1

sequence

PR:000025825 Axin-1 isoform 1, AXIN1/iso:1

organism-sequence

PR:O15169-1 Axin-1 isoform 1 (human), hAXIN1/iso:1

Yes

organism-sequence

PR:O35625-1 Axin-1 isoform 1 (mouse), mAXIN1/iso:1

Yes

sequence

PR:000025826 Axin-1 isoform 2, AXIN1/iso:2

organism-sequence

PR:O15169-2 Axin-1 isoform 2 (human), hAXIN1/iso:2

organism-sequence

PR:O35625-2 Axin-1 isoform 2 (mouse), mAXIN1/iso:2

organism-sequence

PR:O70239-1 Axin-1 isoform 2 (rat), rAXIN1/iso:2

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:O15169-1 hAXIN1/iso:1 "An Axin-1 isoform 1 that is encoded in the genome of human." [PMID:9230313, PRO:CNA]	enables	GO:0005515 protein binding with PR:000036448 hMYC/iso:1/Phos:1	PMID:19131971
	enables	GO:0060090 molecular adaptor activity	PMID:19131971
PR:O35625-1 mAXIN1/iso:1 "An Axin-1 isoform 1 that is encoded in the genome of mouse." [PMID:9230313, PRO:HJD]	acts_upstream_of_or_within	GO:0030178 negative regulation of Wnt signaling pathway	MGI:4462715; PMID:10581160
	enables	GO:0008013 beta-catenin binding	MGI:4462715; PMID:10581160