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Protein Ontology report - IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex
PR:000036052 -
http://purl.obolibrary.org/obo/PR_000036052
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000036052
PRO name
IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex
Synonyms
Other
:
EXACT:
activated TLR4:TRIF:K63-pUb-RIP1:IKKcomplex
Definition
"A protein-containing complex that is composed of activated Toll-like receptor 4 (TLR4), Ticam2 (TRAM), Ticam1 (TRIF), the death receptor RIPK1 (RIP1) cross-linked to K63-linked polyubiquitin, and the IKK complex (consisting of IKKA, IKKB and NEMO)." [
PMID:15064760
,
PMID:15814722
,
PMID:16115877
,
Reactome:R
-HSA-937030]
Comment
Requested by=TLR.
PRO Category
complex
Parent
G0032991
protein-containing complex
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Complex
1
Organism-Complex
1
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
complex
PR:000036052
IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex, hRIPK1/K63polyUbiq:1
organism-complex
PR:000036053
IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human), hRIPK1/K63polyUbiq:1
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000036053
hRIPK1/K63polyUbiq:1
activated TLR4:TRIF:K63-pUb-RIP1:IKKcomplex (human)
"An IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human." [PMID:15064760, PMID:15814722, PMID:16115877, Reactome:R-HSA-937030]
acts_upstream_of_or_within
GO:0002756
MyD88-independent toll-like receptor signaling pathway
Reactome:REACT_6809
located_in
GO:0010008
endosome membrane
Reactome:REACT_26016
