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Protein Ontology report - pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex
PR:000036059 - http://purl.obolibrary.org/obo/PR_000036059
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000036059   
  PRO namepro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex 
  Synonyms
Other: RELATED:activated TLR4:TRIF:RIP1:FADD:pro-caspase-8
  Definition"A protein-containing complex that is composed of activated Toll-like receptor 4 (TLR4), ticam2 (TRAM), ticam1 (TRIF), ripk1 (RIP1), fadd and the procaspase 8 precursor." [Reactome:R-HSA-2562542] 
  CommentRequested by=TLR. 
  PRO Categorycomplex 
  ParentG0032991 protein-containing complex
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Complex1                                                  Organism-Complex 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
complex


PR:000036059 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex, hRIPK1/K63polyUbiq:1

organism-complex


PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human), hRIPK1/K63polyUbiq:1
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036060 hRIPK1/K63polyUbiq:1
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 (human)
"A pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human." [Reactome:R-HSA-2562542]		 acts_upstream_of_or_withinGO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
enablesGO:0004197 cysteine-type endopeptidase activity Reactome:REACT_151344
located_inGO:0010008 endosome membrane Reactome:REACT_151344