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Protein Ontology report - IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR3/TLR4 complex (human)
PR:000036180 - http://purl.obolibrary.org/obo/PR_000036180
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:000036180   
  PRO nameIKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR3/TLR4 complex (human) 
  Synonyms
Other: EXACT:activated TLR3/TLR4:TRIF:K63-pUb-RIP1:IKKcomplex (human)
  Definition"A protein-containing complex in human that is composed of Ticam2 (TRAM), Ticam1 (TRIF), the death receptor RIPK1 (RIP1) cross-linked to K63-linked polyubiquitin, the IKK complex (consisting of IKKA, IKKB and NEMO), and either activated Toll-like receptor 4 (TLR4) or activated Toll-like receptor 3 (TLR3)." [PRO:DAN, Reactome:R-HSA-937030] 
  PRO Categoryorganism-complex 
  ParentG0032991
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Complex0                                                  Organism-Complex 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?
organism-complex



PR:000036180 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR3/TLR4 complex (human), hACTB/Ac:1


organism-complex



PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human), hRIPK1/K63polyUbiq:1


organism-complex



PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human), ARAP3/iso:1


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036053
hRIPK1/K63polyUbiq:1
activated TLR4:TRIF:K63-pUb-RIP1:IKKcomplex (human)
acts_upstream_of_or_withinGO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_inGO:0010008 endosome membrane Reactome:REACT_26016
PR:000037364
ARAP3/iso:1
activated TLR3:TRIF:K63-pUb-RIP1:IKKcomplex (human)
acts_upstream_of_or_withinGO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_inGO:0010008 endosome membrane Reactome:REACT_6783