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Protein Ontology report - NS4A-NS4B-NS5
PR:000036840 -
http://purl.obolibrary.org/obo/PR_000036840
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000036840
PRO name
NS4A-NS4B-NS5
Synonyms
PRO-Short-label
:
EXACT:
DenV-NS4AB5
Definition
"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS345 by the two-component proteinase NS2B-NS3 at the NS3-NS4A site consisting of NS4A, 2K, NS4B, and NS5." [
PMID:1531368
, PRO:ES]
Comment
Requested by=IDODEN. The polyprotein NS4A-NS4B-NS5 was cleaved at the NS4A/NS4B junction in the absence of other dengue virus functions.
PRO Category
modification
Parent
PR:000036818
dengue virus genome polyprotein proteolytic cleavage product
PR:000036839
NS345
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
6
Organism-Modification
3
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000036840
NS4A-NS4B-NS5, DenV-NS4AB5
modification
PR:000036841
NS4AB, DenV-NS4AB
modification
PR:000036830
NS4A, DenV-NS4A
organism-modification
PR:000044763
NS4A (Dengue virus 2 Thailand/NGS-C/1944), NS4A (DEN2N)
Yes
organism-modification
PR:000044764
NS4A (Dengue virus 2 Thailand/16681/84), NS4A (DEN26)
Yes
modification
PR:000036842
2KNS4B, DenV-2KNS4B
modification
PR:000036831
2K, DenV-2K
organism-modification
PR:000044765
2K (Dengue virus 2 Thailand/NGS-C/1944), 2K (DEN2N)
Yes
modification
PR:000036843
NS4B-NS5, DenV-NS4B5
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000044763
NS4A (DEN2N)
UniProtKB:P14340, 2094-2220 | PRO_0000037966
"An NS4A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2094-2220." [PRO:DNx]
acts_upstream_of_or_within
GO:0019079
viral genome replication
PMID:17276984
located_in
GO:0019034
viral replication complex
PMID:17276984
PR:000044764
NS4A (DEN26)
UniProtKB:P29990, 2094-2220 | PRO_0000037933
"An NS4A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2094-2220." [PRO:DNx]
acts_upstream_of_or_within
GO:0060339
negative regulation of type I interferon-mediated signaling pathway
PMID:14612562
PR:000044765
2K (DEN2N)
UniProtKB:P14340, 2221-2243 | PRO_0000261391
"A 2K in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2221-2243." [PRO:DNx]
acts_upstream_of_or_within
GO:0045051
protein insertion into ER membrane by internal uncleaved signal-anchor sequence
PMID:17276984
enables
GO:0043495
protein-membrane adaptor activity
PMID:21810535
located_in
GO:0016020
membrane
PMID:21810535
