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Protein Ontology report - viral dsRNA:TLR3 complex (human) PR:000037303 - http://purl.obolibrary.org/obo/PR_000037303        Annotations       Ontology Information Show OBO stanza / PAF / GPI   PRO ID PR:000037303      PRO name viral dsRNA:TLR3 complex (human)    Synonyms PRO-Short-label: EXACT: h(vir)dsRNA:TLR3   Definition "A viral dsRNA:TLR3 complex whose components are encoded in the genome of human." [PMID:18172197, PMID:19595807, PRO:VS, Reactome:R-HSA-167985]    Comment Requested by=TLR. Note: Viral dsRNA triggers an antiviral pathway mediated by Toll-like receptor 3. TLR3 dimerization occurs upon ligand binding to positivly charged residues on the ectodomain termini of TLR3 wich are responsible for the interaction with sugar-phosphate groups of dsRNA.    PRO Category organism-complex    Parent PR:000037302 viral dsRNA:TLR3 complex   Taxon NCBITaxon:9606 Homo sapiens   Term Hierarchy   Visualization DAG: OLS: Back to top Functional Annotation (PRO-centric view) Switch to GO Centric View    PRO Term GO Annotation Evidence PR:000037303 h(vir)dsRNA:TLR3 "A viral dsRNA:TLR3 complex whose components are encoded in the genome of human." [PMID:18172197, PMID:19595807, PRO:VS, Reactome:R-HSA-167985] acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783