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Protein Ontology report - MD2:GB4:TLR4 complex (mouse)
PR:000037794 -
Ontology Information Show OBO stanza / PAF / GPI
  PRO nameMD2:GB4:TLR4 complex (mouse) 
  Definition"A protein-containing complex in mouse that is composed of two copies of the proteins Toll-like receptor 4 (TLR4) and the lymphocyte antigen 96 (LY96/MD2), and two globotetraosylceramide (GB4) molecules." [PMID:23471986, PRO:CNA] 
  CommentNote: PMID:23471986, binding of Gb4 to the LPS receptor TLR4-MD-2 was demonstrated by coprecipitation of Gb4 with recombinant MD-2 and by native PAGE. Evidence=(ECO:0000269, based on PMID:23471986). 
  PRO Categoryorganism-complex 
  ParentG0032991 protein-containing complex
  TaxonNCBITaxon:10090 Mus musculus
  Term Hierarchy
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000037794 hIRF7/iso:1/UnPhos:1 acts_upstream_of_or_withinGO:0034144 negative regulation of toll-like receptor 4 signaling pathway PMID:23471986
enablesNOT GO:0001530 lipopolysaccharide binding PMID:23471986