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Protein Ontology report - transforming growth factor beta-1, signal peptide removed form (human)
PR:000049430 -
http://purl.obolibrary.org/obo/PR_000049430
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
GPI
PRO ID
PR:000049430
PRO name
transforming growth factor beta-1, signal peptide removed form (human)
Synonyms
PRO-Short-label
:
EXACT:
hTGFB1/SigPep-
PRO-proteoform-std
:
EXACT:
UniProtKB:P01137
, 30-390
Definition
"A transforming growth factor beta-1 (human) that has had the signal peptide removed.
UniProtKB:P01137
, 30-390." [PRO:DNx,
Reactome:R
-HSA-114705]
PRO Category
organism-modification
Parent
PR:000018291
TGF-beta 1, signal peptide removed form
PR:P01137
transforming growth factor beta-1 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
0
Organism-Modification
18
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
organism-modification
PR:000049430
transforming growth factor beta-1, signal peptide removed form (human), hTGFB1/SigPep-
organism-modification
PR:000021903
TGF-beta 1 sequence variant T81H, signal peptide removed form (human), hTGFB1/var:T81H/SigPep-
organism-modification
PR:000000619
TGF-beta 1 sequence variant T81H cleaved 1 (human), hTGFB1/var:T81H/Clv:1
Yes
organism-modification
PR:000000620
TGF-beta 1 sequence variant T81H cleaved 2 (human), hTGFB1/var:T81H/Clv:2
Yes
organism-modification
PR:000021904
TGF-beta 1 sequence variant R218C, signal peptide removed form (human), hTGFB1/var:R218C/SigPep-
organism-modification
PR:000000621
TGF-beta 1 sequence variant R218C cleaved 1 (human), hTGFB1/var:R218C/Clv:1
Yes
organism-modification
PR:000000622
TGF-beta 1 sequence variant R218C cleaved 2 (human), hTGFB1/var:R218C/Clv:2
Yes
organism-modification
PR:000021905
TGF-beta 1 sequence variant H222D, signal peptide removed form (human), hTGFB1/var:H222D/SigPep-
organism-modification
PR:000000623
TGF-beta 1 sequence variant H222D cleaved 1 (human), hTGFB1/var:H222D/Clv:1
Yes
organism-modification
PR:000000624
TGF-beta 1 sequence variant H222D cleaved 2 (human), hTGFB1/var:H222D/Clv:2
Yes
organism-modification
PR:000021906
TGF-beta 1 sequence variant C225R, signal peptide removed form (human), hTGFB1/var:C225R/SigPep-
organism-modification
PR:000000625
TGF-beta 1 sequence variant C225R cleaved 1 (human), hTGFB1/var:C225R/Clv:1
Yes
organism-modification
PR:000000626
TGF-beta 1 sequence variant C225R cleaved 2 (human), hTGFB1/var:C225R/Clv:2
Yes
organism-modification
PR:000021907
TGF-beta 1 sequence variant R218H, signal peptide removed form (human), hTGFB1/var:R218H/SigPep-
organism-modification
PR:000000627
TGF-beta 1 sequence variant R218H cleaved 1 (human), hTGFB1/var:R218H/Clv:1
Yes
organism-modification
PR:000000628
TGF-beta 1 sequence variant R218H cleaved 2 (human), hTGFB1/var:R218H/Clv:2
Yes
organism-modification
PR:000026335
TGF-beta 1 isoform 1 inactive form (human), hTGFB1/iso:1/inactive
Yes
organism-modification
PR:000036526
TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000619
hTGFB1/var:T81H/Clv:1
UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979 | TGF-beta 1 sequence variant 2 cleaved 1 (human)
"A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN]
located_in
SO:0001558
polypeptide_localization_variant
PMID:12493741
PR:000000620
hTGFB1/var:T81H/Clv:2
UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979 | TGF-beta 1 sequence variant 2 cleaved 2 (human)
"A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN]
located_in
GO:0005615
extracellular space
PMID:12493741
PR:000000621
hTGFB1/var:R218C/Clv:1
UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950 | TGF-beta 1 sequence variant 3 cleaved 1 (human)
"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950." [PMID:11278244, PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11062463
;
PMID:12493741
;
PMID:12843182
enables
GO:0005160
transforming growth factor beta receptor binding
PMID:11278244
increased
GO:0008083
growth factor activity
relative to
PR:000000616
TGF-beta 1 active protein
PMID:11062463
;
PMID:12493741
;
PMID:12843182
GO:0042803
protein homodimerization activity
PMID:11062463
;
PMID:12493741
;
PMID:12843182
located_in
GO:0005615
extracellular space
PMID:11062463
;
PMID:12493741
;
PMID:12843182
PR:000000622
hTGFB1/var:R218C/Clv:2
UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950 | TGF-beta 1 sequence variant 3 cleaved 2 (human)
"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide (PR:000000621). UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950." [PMID:10973241, PMID:11062463, PMID:11278244, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN]
located_in
SO:0001561
polypeptide_partial_loss_of_function
PMID:11278244
PR:000000623
hTGFB1/var:H222D/Clv:1
UniProtKB:P01137, 279-390, His-222, CHEBI:29958 | TGF-beta 1 sequence variant 5 cleaved 1 (human)
"A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, His-222, CHEBI:29958." [PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:12493741
GO:0043066
negative regulation of apoptotic process
PMID:12493741
enables
increased
GO:0008083
growth factor activity
relative to
PR:000000616
TGF-beta 1 active protein
PMID:12493741
located_in
GO:0005615
extracellular space
PMID:12493741
PR:000000624
hTGFB1/var:H222D/Clv:2
UniProtKB:P01137, 30-278, His-222, CHEBI:29958 | TGF-beta 1 sequence variant 5 cleaved 2 (human)
"A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, His-222, CHEBI:29958." [PMID:11278244, PRO:CNA, PRO:DAN]
located_in
SO:0001561
polypeptide_partial_loss_of_function
PMID:11278244
SO:0001601
conformational_change_variant
PMID:11278244
PR:000000625
hTGFB1/var:C225R/Clv:1
UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952 | TGF-beta 1 sequence variant 6 cleaved 1 (human)
"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952." [PRO:CNA, PRO:DAN]
enables
increased
GO:0008083
growth factor activity
relative to
PR:000000616
TGF-beta 1 active protein
PMID:11062463
;
PMID:12493741
;
PMID:12843182
located_in
GO:0005615
extracellular space
PMID:11062463
;
PMID:12493741
;
PMID:12843182
PR:000000626
hTGFB1/var:C225R/Clv:2
UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952 | TGF-beta 1 sequence variant 6 cleaved 2 (human)
"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952." [PMID:11278244, PRO:CNA, PRO:DAN]
located_in
SO:0001561
polypeptide_partial_loss_of_function
PMID:11278244
PR:000000627
hTGFB1/var:R218H/Clv:1
UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979 | TGF-beta 1 sequence variant 4 cleaved 1 (human)
"A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11278244
enables
GO:0005160
transforming growth factor beta receptor binding
PMID:11278244
increased
GO:0008083
growth factor activity
relative to
PR:000000616
TGF-beta 1 active protein
PMID:12493741
;
PMID:12843182
GO:0042803
protein homodimerization activity
PMID:11278244
located_in
GO:0005615
extracellular space
PMID:11278244
PR:000000628
hTGFB1/var:R218H/Clv:2
UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979 | TGF-beta 1 sequence variant 4 cleaved 2 (human)
"A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide. UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN]
located_in
SO:0001561
polypeptide_partial_loss_of_function
PMID:11278244
SO:0001601
conformational_change_variant
PMID:11278244
PR:000026335
hTGFB1/iso:1/inactive
UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160 | PRO_0000033762, PRO_0000033763, Asn-82, MOD:00160
"A TGF-beta 1 isoform 1 inactive form in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PRO:DAN]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:3162913
enables
NOT
GO:0005160
transforming growth factor beta receptor binding
PMID:2677679
;
PMID:3162913
GO:0042803
protein homodimerization activity
PMID:3162913
located_in
GO:0031012
extracellular matrix
PMID:17015622
;
PMID:8294500
GO:0032991
protein-containing complex
PMID:3162913
PR:000036526
hTGFB1/iso:1/LAP
UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160
"A TGF-beta 1 isoform 1 latency associated peptide in human. UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:17015622, PMID:3162913, PRO:CNA, PRO:DAN]
located_in
GO:0032991
protein-containing complex
PMID:17015622
;
PMID:3162913
