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| heteromeric SMAD protein complex | A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric. [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020] | | GO:0005667; G0071141 |
| inhibitory smad protein | A smad protein that is an antagonist of the transforming growth factor beta (TGF-beta) superfamily signaling pathways. It lacks the C-terminal SSxS motif, necessary for receptor mediated phosphorylation that is present in the receptor-regulated smads. [PMID:11532220] | family | PR:000000027 |
| smad protein | A protein with core domain composition consisting of one MH1 domain (Pfam:PF03165) at the N terminus and one MH2 domain (Pfam:PF03166) at the C-terminus, separated by a non-conserved linker region. Smad proteins are mediators of signal transduction in transforming growth factor beta (TGF-beta) superfamily pathways. [PRO:CNA] | family | PR:000000001 |
| smad ubiquitination regulatory factor | A HECT domain-containing E3 ubiquitin-protein ligase with WW domains that mediates smad ubiquitination. [PRO:CNA] | family | PR:000000016 |
| SMAD protein complex | A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven. [GOC:bhm, GOC:mah, PMID:9670020] | | GO:0032991 |
| BMP receptor-regulated smad protein | A smad protein that mediates signal transduction through activation of bone morphogenetic protein (BMP) or anti-Mullerian hormone pathways. [PMID:11532220] | family | PR:000000027 |
| TGF-beta receptor-regulated smad protein unmodified form | A TGF-beta receptor-regulated smad protein that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage. [PRO:CNA] | modification | PR:000000066 |
| TGF-beta receptor-regulated smad protein unmodified form (human) | A TGF-beta receptor-regulated smad protein unmodified form in human. [PRO:CNA] | organism-modification | PR:000027744; PR:000029067 |
| smad nuclear interacting protein 1 (rat) | A smad nuclear-interacting protein 1 that is encoded in the genome of rat. [OMA:Q5M9G6, PRO:DNx] | organism-gene | PR:000015328; PR:000029033 |
| smad nuclear-interacting protein 1 (mouse) | A smad nuclear-interacting protein 1 that is encoded in the genome of mouse. [OMA:Q8BIZ6, PRO:DNx] | organism-gene | PR:000015328; PR:000029032 |
| TGF-beta receptor-regulated smad protein | A smad protein that mediates signal transduction through activation of transforming growth factor beta (TGF-beta) or activin pathways. [PMID:11532220] | family | PR:000000027 |
| smad nuclear-interacting protein 1 (human) | A smad nuclear-interacting protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TAD8] | organism-gene | PR:000015328; PR:000029067 |
| TGF-beta receptor-regulated smad protein phosphorylated form (human) | A TGF-beta receptor-regulated smad protein phosphorylated form in human. [PRO:CNA] | organism-modification | PR:000027746; PR:000029067 |
| TGF-beta receptor-regulated smad protein phosphorylated form | A TGF-beta receptor-regulated smad protein that has been phosphorylated in the last two Ser residues within the SSxS C-terminal motif by TGF-beta pathway activation. [PRO:CNA] | modification | PR:000000066 |
| smad protein daf-3 isoform i (worm) | A smad protein daf-3 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q95QI7-9. [PRO:DNx, UniProtKB:Q95QI7] | organism-sequence | PR:Q95QI7 |
| smad protein daf-3 isoform h (worm) | A smad protein daf-3 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q95QI7-8. [PRO:DNx, UniProtKB:Q95QI7] | organism-sequence | PR:Q95QI7 |
| smad protein daf-3 isoform g (worm) | A smad protein daf-3 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q95QI7-7. [PRO:DNx, UniProtKB:Q95QI7] | organism-sequence | PR:Q95QI7 |
| smad protein daf-3 isoform c (worm) | A smad protein daf-3 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q95QI7-6. [PRO:DNx, UniProtKB:Q95QI7] | organism-sequence | PR:Q95QI7 |
| smad protein daf-3 isoform b (worm) | A smad protein daf-3 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q95QI7-5. [PRO:DNx, UniProtKB:Q95QI7] | organism-sequence | PR:Q95QI7 |
| smad protein daf-3 isoform e (worm) | A smad protein daf-3 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q95QI7-4. [PRO:DNx, UniProtKB:Q95QI7] | organism-sequence | PR:Q95QI7 |
| smad protein daf-3 isoform f (worm) | A smad protein daf-3 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q95QI7-3. [PRO:DNx, UniProtKB:Q95QI7] | organism-sequence | PR:Q95QI7 |
| smad protein daf-3 isoform d (worm) | A smad protein daf-3 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q95QI7-2. [PRO:DNx, UniProtKB:Q95QI7] | organism-sequence | PR:Q95QI7 |
| smad protein daf-3 isoform a (worm) | A smad protein daf-3 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q95QI7-1. [PRO:DNx, UniProtKB:Q95QI7] | organism-sequence | PR:Q95QI7 |
| smad-related protein daf-14 isoform a (worm) | A smad-related protein daf-14 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:F5GUE5-2. [PRO:DNx, UniProtKB:F5GUE5] | organism-sequence | PR:F5GUE5 |
| smad-related protein daf-14 isoform b (worm) | A smad-related protein daf-14 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:F5GUE5-1. [PRO:DNx, UniProtKB:F5GUE5] | organism-sequence | PR:F5GUE5 |
| smad9 | A BMP receptor-regulated smad protein that is a translation product of the human SMAD9 gene or a 1:1 ortholog thereof. [PMID:10708948] | gene | PR:000000038 |
| smad5 | A BMP receptor-regulated smad protein that is a translation product of the human SMAD5 gene or a 1:1 ortholog thereof. [PMID:10708949] | gene | PR:000000038 |
| smad4 | A smad protein that is a translation product of the human SMAD4 gene or a 1:1 ortholog thereof. It lacks the C-terminal SSxS motif, necessary for receptor mediated phosphorylation, that is present in the receptor-regulated smads. [PMID:10708949, PRO:CNA] | gene | PR:000000027 |
| smad7 | An inhibitory smad protein that is a translation product of the human SMAD7 gene or a 1:1 ortholog thereof. Smad7 is a negative regulator of TGF-beta signaling. [PMID:17438144] | gene | PR:000000099 |
| smad1 | A BMP receptor-regulated smad protein that is a translation product of the human SMAD1 gene or a 1:1 ortholog thereof. [PMID:10708949, PRO:CNA] | gene | PR:000000038 |
| smad5 isoform 2 | A smad5 that is a translation product of a transcript comprising intron 6 generating a C-terminus truncated MH2 domain and a unique C-terminus sequence lacking the SSxS motif necessary for SMAD activation. [EST:AA169504, PMID:10845932, PRO:CNA, PRO:DAN] | sequence | PR:000000372 |
| smad3 | A TGF-beta receptor-regulated smad protein that is a translation product of the human SMAD3 gene or a 1:1 ortholog thereof. [PMID:9311995] | gene | PR:000000066 |
| smad nuclear-interacting protein 1 | A protein that is a translation product of the human SNIP1 gene or a 1:1 ortholog thereof. [PRO:DNx] | gene | PR:000000001 |
| smad6 | An inhibitory smad protein that is a translation product of the human SMAD6 gene or a 1:1 ortholog thereof. Inhibitor of bone morphogenetic protein (BMP) signaling, and the interaction with BMP type 1 receptors is a critical step in the function of smad6. [PMID:17493940] | gene | PR:000000099 |
| smad protein daf-3 (worm) | A protein that is a translation product of the daf-3 gene in worm. [PRO:DNx, UniProtKB:Q95QI7] | organism-gene | PR:000036194 |
| smad protein daf-8 (worm) | A protein that is a translation product of the daf-8 gene in worm. [PRO:DNx, UniProtKB:Q21733] | organism-gene | PR:000036194 |
| smad2 | A TGF-beta receptor-regulated smad protein that is a translation product of the human SMAD2 gene or a 1:1 ortholog thereof. [PMID:9311995] | gene | PR:000000066 |
| sara-type zinc finger FYVE domain-containing protein | A protein that has a core domain composition consisting of a FYVE zinc finger (Pfam:PF01363) domain and a smad-binding domain that is involved in recruiting and presenting receptor-regulated smads to the receptor complex. [PMID:17356069] | family | PR:000000001 |
| smad-related protein daf-14 (worm) | A protein that is a translation product of the daf-14 gene in worm. [PRO:DNx, UniProtKB:F5GUE5] | organism-gene | PR:000036194 |
| E3 ubiquitin-protein ligase SMURF2 | A smad ubiquitination regulatory factor that is a translation product of the human SMURF2 gene or a 1:1 ortholog thereof. [PRO:CNA] | gene | PR:000000127 |
| E3 ubiquitin-protein ligase SMURF1 | A smad ubiquitination regulatory factor that is a translation product of the human SMURF1 gene or a 1:1 ortholog thereof. [PRO:CNA] | gene | PR:000000127 |
| CG17168 protein (fruit fly) | A smad nuclear-interacting protein 1 that is encoded in the genome of fruit fly. [PANTHER:PTHR23308:SF8, PRO:DNx] | organism-gene | PR:000015328; PR:000029060 |
| C32E8.5 protein (worm) | A smad nuclear-interacting protein 1 that is encoded in the genome of worm. [PANTHER:PTHR23308:SF8, PRO:DNx] | organism-gene | PR:000015328; PR:000036194 |
| smad2-smad4 protein complex 4 | A smad2-smad4 protein complex that contains smad4 and smad2 phosphorylated on a [S/T] residue within the MH1-MH2 domain linker region in response to decorin-induced Ca(2+) signaling. [PMID:11027280] | complex | GO:0071144 |
| smad2-smad4 protein complex 3 | A smad2-smad4 protein complex that contains smad4 and the long isoform of SMAD2 phosphorylated by ERK1. [PMID:12193595] | complex | GO:0071144 |
| SMAD5 antisense gene protein 1 | A protein that is a translation product of the human SMAD5-AS1 gene or a 1:1 ortholog thereof. [PRO:DNx] | gene | PR:000000001 |
| smad6 isoform 2 | A smad6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43541-2 or a 1:1 ortholog thereof. [PMID:11284962, PRO:CNA, PRO:DAN] | sequence | PR:000000373 |
| mothers against decapentaplegic homolog 9 (mouse) | A smad9 that is encoded in the genome of mouse. [OMA:Q9JIW5, PRO:DNx] | organism-gene | PR:000000375; PR:000029032 |
| mothers against decapentaplegic homolog 9 (rat) | A smad9 that is encoded in the genome of rat. [OMA:O54835, PRO:DNx] | organism-gene | PR:000000375; PR:000029033 |
| smad9 isoform 1 | A smad9 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JIW5-1 or a 1:1 ortholog thereof. [PRO:CNA, PRO:DAN] | sequence | PR:000000375 |
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