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Protein Ontology Report - CEACAM1

PR:000001328 - http://purl.obolibrary.org/obo/PR_000001328
Ontology Information
PRO ID PR:000001328 Show OBO stanza / PAF
PRO name carcinoembryonic antigen-related cell adhesion molecule 1
Synonyms
PRO-short-label: EXACT: CEACAM1
Gene-based: RELATED: BGP | BGP1
Other: EXACT: BGP-1 | CD66a | MHV-R | MHVR1 | biliary glycoprotein 1 | biliary glycoprotein D
RELATED: Bgpd | murine hepatitis virus receptor
BROAD: pp120
Definition A protein that is a translation product of the human CEACAM1 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 0 organism-sequence 29
modification 1 organism-modification 15
union 2
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:P31809-4
mCEACAM1a/iso:2S
acts_upstream_of_or_within GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules MGI:5503958, PMID:10491101
located_in GO:0009897 external side of plasma membrane MGI:5503958, PMID:10491101
located_in GO:0009897 external side of plasma membrane MGI:81180, PMID:8896983
PR:P31809-1
mCEACAM1a/iso:4L
acts_upstream_of_or_within GO:0042130 negative regulation of T cell proliferation MGI:3693042, PMID:17081782
acts_upstream_of_or_within GO:0032703 negative regulation of interleukin-2 production MGI:3693042, PMID:17081782
PR:P31809-3
mCEACAM1a/iso:3
acts_upstream_of_or_within GO:0046329 negative regulation of JNK cascade MGI:3693042, PMID:17081782
acts_upstream_of_or_within GO:0032703 negative regulation of interleukin-2 production MGI:3693042, PMID:17081782
PR:000044488
mCEACAM1a/iso:2S/SigPep-/NGlycoAsn+
MOD:00160 		enables GO:0046790 virion binding MGI:3053174, PMID:8380065
PR:000044489
mCEACAM1a/iso:4/NGlycoAsp+
acts_upstream_of_or_within GO:0044794 positive regulation by host of viral process MGI:2148352, PMID:11483763
enables NOT GO:0001618 virus receptor activity MGI:5608587, PMID:2164599
located_in GO:0016020 membrane MGI:63233, PMID:8402684
located_in GO:0031526 brush border membrane MGI:73162, PMID:1648219
located_in GO:0016020 membrane MGI:5608587, PMID:2164599
located_in GO:0016020 membrane MGI:73162, PMID:1648219
PR:000044469
mCEACAM1a/iso:4C1/SigPep-/NGlycoAsn+
MOD:00160 		acts_upstream_of_or_within GO:0044793 negative regulation by host of viral process MGI:3848729, PMID:19358828
located_in GO:0005615 extracellular space MGI:3848729, PMID:19358828
PR:000044490
mCEACAM1a/iso:2/NGlycoAsp+
acts_upstream_of_or_within GO:0044793 negative regulation by host of viral process MGI:2148352, PMID:11483763
enables NOT GO:0001618 virus receptor activity MGI:5608587, PMID:2164599
located_in GO:0016020 membrane MGI:5608587, PMID:2164599
located_in GO:0016020 membrane MGI:63233, PMID:8402684
located_in GO:0031526 brush border membrane MGI:73162, PMID:1648219
PR:000044466
mCEACAM1a
acts_upstream_of_or_within GO:0044794 positive regulation by host of viral process MGI:1098064, PMID:9343248
PR:000044467
mCEACAM1b
acts_upstream_of_or_within GO:0044828 negative regulation by host of viral genome replication MGI:55926, PMID:6327825
acts_upstream_of_or_within GO:0044793 negative regulation by host of viral process MGI:1098064, PMID:9343248
PR:000044465
mCEACAM1a/iso:4S/SigPep-/NGlycoAsn+
MOD:00160 		acts_upstream_of_or_within GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation MGI:5451119, PMID:23123061
acts_upstream_of_or_within GO:0046718 viral entry into host cell MGI:49235, PMID:1719235
acts_upstream_of_or_within GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation MGI:5451119, PMID:23123061
acts_upstream_of_or_within GO:0002639 positive regulation of immunoglobulin production MGI:5451119, PMID:23123061
acts_upstream_of_or_within GO:0070237 positive regulation of activation-induced cell death of T cells MGI:5451119, PMID:23123061
acts_upstream_of_or_within GO:0048541 Peyer's patch development MGI:5451119, PMID:23123061
acts_upstream_of_or_within GO:0070886 positive regulation of calcineurin-NFAT signaling cascade MGI:5451119, PMID:23123061
acts_upstream_of_or_within GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules MGI:5608586, PMID:1633107
acts_upstream_of_or_within GO:0042102 positive regulation of T cell proliferation MGI:5451119, PMID:23123061
acts_upstream_of_or_within GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation MGI:5451119, PMID:23123061
enables GO:0046790 virion binding MGI:3053174, PMID:8380065
enables GO:0001618 virus receptor activity MGI:49235, PMID:1719235
located_in GO:0009897 external side of plasma membrane MGI:81180, PMID:8896983
located_in GO:0009897 external side of plasma membrane MGI:5608586, PMID:1633107
PR:000044471
mCEACAM1a/iso:2/SigPep-/NGlycoAsn+
MOD:00160 		located_in GO:0005615 extracellular space MGI:3848729, PMID:19358828
PR:000044470
mCEACAM1a/iso:2C1/SigPep-/NGlycoAsn+
MOD:00160 		located_in GO:0005615 extracellular space MGI:3848729, PMID:19358828
PR:000044464
mCEACAM1a/iso:4L/SigPep-/NGlycoPhos:1
Tyr-488/Tyr-515, MOD:00048|MOD:00160 		enables GO:0005515 protein binding with PR:P35235 mPTPN11 MGI:1326994, PMID:9867848
enables GO:0005515 protein binding with PR:P29351 mPTPN6 MGI:1326994, PMID:9867848
enables GO:0005515 protein binding with PR:P29351 mPTPN6 MGI:86453, PMID:9047385
PR:000044472
mCEACAM1b/iso:2S/SigPep-/NGlycoAsn+
MOD:00160 		enables NOT GO:0046790 virion binding MGI:3053174, PMID:8380065
PR:Q99232
mCEACAM1b/iso:2S
acts_upstream_of_or_within GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules MGI:59357, PMID:1985902
PR:000044502
mCEACAM1a/iso:C1/SigPep-/NGlycoAsn+
located_in GO:0005615 extracellular space MGI:3848729, PMID:19358828
PR:000044501
mCEACAM1b/iso:4/SigPep-/NGlycoAsn+
located_in GO:0031526 brush border membrane MGI:73162, PMID:1648219
PR:000044463
mCEACAM1a/iso:4L/SigPep-/NGlycoAsn+
MOD:00160 		acts_upstream_of_or_within GO:0042130 negative regulation of T cell proliferation MGI:3693042, PMID:17081782
acts_upstream_of_or_within GO:0032703 negative regulation of interleukin-2 production MGI:3693042, PMID:17081782
acts_upstream_of_or_within GO:0042130 negative regulation of T cell proliferation MGI:5451119, PMID:23123061
located_in GO:0009897 external side of plasma membrane MGI:3693042, PMID:17081782
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0016020 membrane PR:000044489 mCEACAM1a/iso:4/NGlycoAsp+

MGI:63233, PMID:8402684
PR:000044489 mCEACAM1a/iso:4/NGlycoAsp+

MGI:5608587, PMID:2164599
PR:000044489 mCEACAM1a/iso:4/NGlycoAsp+

MGI:73162, PMID:1648219
PR:000044490 mCEACAM1a/iso:2/NGlycoAsp+

MGI:5608587, PMID:2164599
PR:000044490 mCEACAM1a/iso:2/NGlycoAsp+

MGI:63233, PMID:8402684
GO:0009897 external side of plasma membrane PR:000044463 mCEACAM1a/iso:4L/SigPep-/NGlycoAsn+
MOD:00160
MGI:3693042, PMID:17081782
PR:000044465 mCEACAM1a/iso:4S/SigPep-/NGlycoAsn+
MOD:00160
MGI:81180, PMID:8896983
PR:000044465 mCEACAM1a/iso:4S/SigPep-/NGlycoAsn+
MOD:00160
MGI:5608586, PMID:1633107
PR:P31809-4 mCEACAM1a/iso:2S

MGI:5503958, PMID:10491101
PR:P31809-4 mCEACAM1a/iso:2S

MGI:81180, PMID:8896983
GO:0031526 brush border membrane PR:000044489 mCEACAM1a/iso:4/NGlycoAsp+

MGI:73162, PMID:1648219
PR:000044490 mCEACAM1a/iso:2/NGlycoAsp+

MGI:73162, PMID:1648219
PR:000044501 mCEACAM1b/iso:4/SigPep-/NGlycoAsn+

MGI:73162, PMID:1648219
GO:0005615 extracellular space PR:000044469 mCEACAM1a/iso:4C1/SigPep-/NGlycoAsn+
MOD:00160
MGI:3848729, PMID:19358828
PR:000044470 mCEACAM1a/iso:2C1/SigPep-/NGlycoAsn+
MOD:00160
MGI:3848729, PMID:19358828
PR:000044471 mCEACAM1a/iso:2/SigPep-/NGlycoAsn+
MOD:00160
MGI:3848729, PMID:19358828
PR:000044502 mCEACAM1a/iso:C1/SigPep-/NGlycoAsn+

MGI:3848729, PMID:19358828

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