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Protein Ontology Report - pTIRAP:PIP2:BTK:activated TLR4 complex (human)

PR:000037448 - http://purl.obolibrary.org/obo/PR_000037448
Ontology Information
PRO ID PR:000037448 Show OBO stanza / PAF
PRO name pTIRAP:PIP2:BTK:activated TLR4 complex (human)
Synonyms
EXACT: p-4Y-MAL:PI(4,5)P2:BTK:activated TLR4 (human); p-4Y-TIRAP:PI(4,5)P2:BTK:activated TLR4 (human); p4Y-MAL:PIP2:BTK:activated TLR4 (human)
Definition A TIRAP:PIP2:BTK:activated TLR4 complex that consists of PI(4,5)P2, tyrosine phosphorylated TIRAP/MAL, BTK, TLR4, MD2, CD14, LPS in human. TIRAP/MAL undergoes tyrosine phosphorylation mediated by Bruton's tyrosine kinase (BTK) within the complex. [PMID:12888566, Reactome:R-HSA-2201325]
Comment Kinase=("TIRAP:PIP2:BTK:activated TLR4 complex (human)"; PR:000037447).
PRO Category organism-complex
Parent PR:000037472 TIRAP:PIP2:BTK:activated TLR4 complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037448 PR:000044351 tyrosine-protein kinase BTK, initiator methionine removed form (human) hBTK/InitMet- A tyrosine-protein kinase BTK, initiator methionine removed form in human. Example: UniProtKB:Q06187-1, 2-659. [PRO:CNA, UniProtKB:Q06187] 2
PR:000025786 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human) hLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:11706042, PMID:17569869, TLR:AMM] 2
PR:000027214 Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 (human) hTIRAP/iso:1/Phos:1 A Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 in human. UniProtKB:P58753-1, (Tyr-86, MOD:00048 or Tyr-106, MOD:00048 or Tyr-159, MOD:00048). [PMID:16439361, PMID:18070880, PRO:CNA] 2
PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human) hTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480] 2
PR:000037480 CD14 molecule isoform 1 cleaved 2 (human) hCD14/iso:1/Clv:2 A CD14 molecule isoform 1 cleaved 2 in human. This represents both the GPI-anchored and soluble forms. [PRO:CNA, PRO:DAN] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2
CHEBI:18348 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate A phosphatidylinositol bisphosphate in which the two phosphate groups are at C-4 and C-5 of the inositol moiety which has the 1D-myo configuration. [None]


Functional Annotation
PRO Term GO Annotation Evidence
PR:000037448
pTIRAP:PIP2:BTK:activated TLR4 complex (human)
located_in GO:0005886 plasma membrane Reactome:REACT_125282
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_125282
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_125282
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002755 MyD88-dependent toll-like receptor signaling pathway PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282
GO:0034142 toll-like receptor 4 signaling pathway PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005886 plasma membrane PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282

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