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Protein Ontology Report - TIRAP:PIP2:BTK:activated TLR4 complex

PR:000037472 - http://purl.obolibrary.org/obo/PR_000037472
Ontology Information
PRO ID PR:000037472 Show OBO stanza / PAF
PRO name TIRAP:PIP2:BTK:activated TLR4 complex
Synonyms
Other: EXACT: MAL:PI(4,5)P2:BTK:activated TLR4
Definition A receptor complex that is composed of PI(4,5)P2, TIRAP/MAL, and BTK, bound to activated TLR4 complex. [PMID:11544529, PMID:12724322, PMID:12888566, Reactome:R-HSA-2201331]
PRO Category complex
Parent GO:0043235 receptor complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 4
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037477 PR:P35991 tyrosine-protein kinase BTK (mouse) mBTK A tyrosine-protein kinase BTK that is encoded in the genome of mouse. [OMA:P35991, PRO:WCB] 2
PR:Q99JY1 Toll/interleukin-1 receptor domain-containing adapter protein (mouse) mTIRAP A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of mouse. [OMA:Q99JY1, PRO:CNA] 2
PR:000027171 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed glycosylated form in mouse that has been N-glycosylated on Asn residues at positions 26, 114, and 150 of the amino acid sequence represented by UniProtKB:Q9JHF9-1. UniProtKB:Q9JHF9-1, 19-160, Asn-26/Asn-114/Asn-150, MOD:00160. [PMID:17803912, PRO:CNA] 2
PR:000027172 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160. [PMID:17803912, PRO:CNA] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2
CHEBI:18348 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate A phosphatidylinositol bisphosphate in which the two phosphate groups are at C-4 and C-5 of the inositol moiety which has the 1D-myo configuration. [None]
PR:000037448 PR:000044351 tyrosine-protein kinase BTK, initiator methionine removed form (human) hBTK/InitMet- A tyrosine-protein kinase BTK, initiator methionine removed form in human. Example: UniProtKB:Q06187-1, 2-659. [PRO:CNA, UniProtKB:Q06187] 2
PR:000025786 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human) hLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:11706042, PMID:17569869, TLR:AMM] 2
PR:000027214 Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 (human) hTIRAP/iso:1/Phos:1 A Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 in human. UniProtKB:P58753-1, (Tyr-86, MOD:00048 or Tyr-106, MOD:00048 or Tyr-159, MOD:00048). [PMID:16439361, PMID:18070880, PRO:CNA] 2
PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human) hTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480] 2
PR:000037480 CD14 molecule isoform 1 cleaved 2 (human) hCD14/iso:1/Clv:2 A CD14 molecule isoform 1 cleaved 2 in human. This represents both the GPI-anchored and soluble forms. [PRO:CNA, PRO:DAN] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2
CHEBI:18348 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate A phosphatidylinositol bisphosphate in which the two phosphate groups are at C-4 and C-5 of the inositol moiety which has the 1D-myo configuration. [None]
PR:000037447 PR:P58753 Toll/interleukin-1 receptor domain-containing adapter protein (human) hTIRAP A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of human. [PRO:CNA] 2
PR:000044351 tyrosine-protein kinase BTK, initiator methionine removed form (human) hBTK/InitMet- A tyrosine-protein kinase BTK, initiator methionine removed form in human. Example: UniProtKB:Q06187-1, 2-659. [PRO:CNA, UniProtKB:Q06187] 2
PR:000025786 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human) hLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:11706042, PMID:17569869, TLR:AMM] 2
PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human) hTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480] 2
PR:000037480 CD14 molecule isoform 1 cleaved 2 (human) hCD14/iso:1/Clv:2 A CD14 molecule isoform 1 cleaved 2 in human. This represents both the GPI-anchored and soluble forms. [PRO:CNA, PRO:DAN] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2
CHEBI:18348 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate A phosphatidylinositol bisphosphate in which the two phosphate groups are at C-4 and C-5 of the inositol moiety which has the 1D-myo configuration. [None]
PR:000037478 PR:P35991 tyrosine-protein kinase BTK (mouse) mBTK A tyrosine-protein kinase BTK that is encoded in the genome of mouse. [OMA:P35991, PRO:WCB] 2
PR:000027171 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed glycosylated form in mouse that has been N-glycosylated on Asn residues at positions 26, 114, and 150 of the amino acid sequence represented by UniProtKB:Q9JHF9-1. UniProtKB:Q9JHF9-1, 19-160, Asn-26/Asn-114/Asn-150, MOD:00160. [PMID:17803912, PRO:CNA] 2
PR:000027216 Toll/interleukin-1 receptor domain-containing adapter protein phosphorylated 1 (mouse) mTIRAP/Phos:1 A Toll/interleukin-1 receptor domain-containing adapter protein (mouse) that has been phosphorylated on Tyr residues by the BTK in mouse. [PRO:CNA] 2
PR:000027172 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160. [PMID:17803912, PRO:CNA] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2
CHEBI:18348 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate A phosphatidylinositol bisphosphate in which the two phosphate groups are at C-4 and C-5 of the inositol moiety which has the 1D-myo configuration. [None]


Functional Annotation
PRO Term GO Annotation Evidence
PR:000037448
pTIRAP:PIP2:BTK:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_125282
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_125282
located_in GO:0005886 plasma membrane Reactome:REACT_125282
PR:000037447
TIRAP:PIP2:BTK:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_120882
acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_120882
enables GO:0004713 protein tyrosine kinase activity Reactome:REACT_120882
located_in GO:0005886 plasma membrane Reactome:REACT_120882
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005886 plasma membrane PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_120882
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282

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