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Protein Ontology Report - hTIRAP

PR:P58753 - http://purl.obolibrary.org/obo/PR_P58753
This page represents a class of proteins encompassing all the protein products of the TIRAP gene in human.
Ontology Information
PRO ID PR:P58753 Show OBO stanza / PAF
PRO name Toll/interleukin-1 receptor domain-containing adapter protein (human)
Synonyms
PRO-short-label: hTIRAP
EXACT: MyD88 adapter-like protein (human); MyD88-2 (human); TIR domain-containing adapter protein (human); adaptor protein Wyatt (human)
Gene-based: MAL; TIRAP
Definition A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of human. [PRO:CNA]
PRO Category organism-gene
Parent PR:000001751 Toll/interleukin-1 receptor domain-containing adapter protein
Gene Template HGNC:17192 TIRAP
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 3
organism-modification 2
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTIRAP forms found in complexes
hTIRAP Component Complexes
PR:000001751 TIRAP PR:000025784 MYD88:TIRAP:activated TLR4 receptor
PR:000001751 TIRAP PR:000036006 TIRAP:PIP2 complex
PR:000001751 TIRAP PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex
PR:000027214 hTIRAP/iso:1/Phos:1 PR:000027218 pTIRAP:PIP2:activated TLR4 complex (human)
PR:000027214 hTIRAP/iso:1/Phos:1 PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000027214 hTIRAP/iso:1/Phos:1 PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:P58753 hTIRAP PR:000036014 TIRAP:PIP2 complex (human)
PR:P58753 hTIRAP PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:P58753 hTIRAP PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
PR:P58753-1 hTIRAP/iso:1 PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:P58753-1 hTIRAP/iso:1 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
PR:P58753-1 hTIRAP/iso:1 PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000027495
pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000001751
TIRAP
has_part Pfam:PF01582 TIR domain
PR:000036135
TIRAP:PIP2:activated TLR4 complex (human)
located_in GO:0005886 plasma membrane Reactome:REACT_152404
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222
PR:P58753-2
hTIRAP/iso:2
capable_of GO:0005546 phosphatidylinositol-4,5-bisphosphate binding PMID:24529375
PR:000037448
pTIRAP:PIP2:BTK:activated TLR4 complex (human)
located_in GO:0005886 plasma membrane Reactome:REACT_125282
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_125282
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_125282
PR:000036014
TIRAP:PIP2 complex (human)
located_in GO:0005886 plasma membrane Reactome:REACT_151450
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222
PR:000027192
pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000027183
IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000037447
TIRAP:PIP2:BTK:activated TLR4 complex (human)
capable_of GO:0004713 protein tyrosine kinase activity Reactome:REACT_120882
located_in GO:0005886 plasma membrane Reactome:REACT_120882
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_120882
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_120882
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002755 MyD88-dependent toll-like receptor signaling pathway PR:000036014 TIRAP:PIP2 complex (human)

Reactome:REACT_25222
PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)

Reactome:REACT_25222
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_120882
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282
GO:0034142 toll-like receptor 4 signaling pathway PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)

Reactome:REACT_6894
PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)

Reactome:REACT_6894
PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)

Reactome:REACT_6894
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_120882
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005886 plasma membrane PR:000036014 TIRAP:PIP2 complex (human)

Reactome:REACT_151450
PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)

Reactome:REACT_152404
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_120882
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282

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