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Protein Ontology Report - hTLR4/iso:1/SigPep-/NGlyco:1

PR:000025787 - http://purl.obolibrary.org/obo/PR_000025787
Ontology Information
PRO ID PR:000025787 Show OBO stanza / GPI
PRO name Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
Synonyms
PRO-short-label: EXACT: hTLR4/iso:1/SigPep-/NGlyco:1
PRO-proteoform-std: EXACT: UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160
PRO-proteoform-ftid: EXACT: PRO_0000034722, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160
Other: EXACT: Toll-like receptor 4 isoform 1 cleaved and glycosylated 1 (human)
Definition A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480]
Comment Note: The Reactome cross-reference cites only glycosylations at positions 526 and 575, as these were found to be the key functional modifications. Nonetheless, structural studies indicate the modifications listed here provide a more-complete representation. [PRO:DAN, PMID:11706042]
PRO Category organism-modification
Parent PR:000025492 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1
Taxon NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTLR4/iso:1/SigPep-/NGlyco:1 forms found in complexes
hTLR4/iso:1/SigPep-/NGlyco:1 Component Complexes
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000036004 LY96:TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000044684 activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000025773 lipopolysaccharide receptor complex 3 (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000037479 lipopolysaccharide receptor complex 4 (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000027218 pTIRAP:PIP2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000025787 hTLR4/iso:1/SigPep-/NGlyco:1 PR:000028678 ticam2:activated TLR4 complex (human)

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