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Protein Ontology Report - MYC

PR:000000084 - http://purl.obolibrary.org/obo/PR_000000084
Ontology Information
PRO ID PR:000000084 Show OBO stanza / PAF
PRO name c-myc protein
Synonyms
PRO-short-label: EXACT: MYC
Gene-based: RELATED: BHLHE39
Other: EXACT: bHLHe39 | class E basic helix-loop-helix protein 39 | proto-oncogene c-Myc | transcription factor p64
Definition A Myc protein that is a translation product of the human MYC gene or a 1:1 ortholog thereof. The gene has 3 exons, with exon 1 lacking ATG codons. [PRO:CNA]
PRO Category gene
Parent PR:000000020 Myc protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 5
sequence 2 organism-sequence 4
modification 10 organism-modification 10
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

MYC forms found in complexes
MYC Component Complexes
PR:000026033 hMYC/iso:1/Ac:1 PR:000026035 Myc-max acetylated complex (human)
PR:000026038 hMYC/iso:1/UnMod PR:000026039 Myc-max complex 1 (human)
PR:P01106 hMYC PR:000025987 Myc-max complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000026039
Myc-max complex 1 (human)
enables GO:0070888 E-box binding PMID:15003254
PR:P01106-1
hMYC/iso:1
acts_upstream_of_or_within GO:0008283 cell population proliferation PMID:10962037
acts_upstream_of_or_within GO:0051726 regulation of cell cycle PMID:10962037
acts_upstream_of_or_within GO:0006357 regulation of transcription by RNA polymerase II PMID:16908182, PMID:2006410
enables GO:0005515 protein binding PMID:12706874
enables GO:0003700 DNA-binding transcription factor activity PMID:16908182, PMID:2006410
part_of GO:0005667 transcription factor complex PMID:16908182, PMID:2006410
PR:P01106-2
hMYC/iso:2
enables GO:0003700 DNA-binding transcription factor activity PMID:3277717
PR:P01108-1
mMYC/iso:1
located_in GO:0005634 nucleus PMID:15503302, PMID:16908182
PR:000026033
hMYC/iso:1/Ac:1
Lys-143/Lys-157/Lys-275/Lys-317/Lys-323/Lys-371, MOD:00394 		enables GO:0003700 DNA-binding transcription factor activity PMID:16126174
located_in GO:0005634 nucleus PMID:16126174
part_of GO:0005667 transcription factor complex PMID:16126174
PR:B2RSN1
mMYC/iso:2
enables GO:0003700 DNA-binding transcription factor activity PMID:7958908
part_of GO:0005667 transcription factor complex PMID:7958908
PR:000026035
Myc-max acetylated complex (human)
enables GO:0070888 E-box binding PMID:16126174
enables GO:0008134 transcription factor binding with PR:Q13105 hZBTB17 PMID:16126174
PR:000026052
mMYC/iso:1/Phos:1
Ser-62, MOD:00046 		acts_upstream_of_or_within GO:0006357 regulation of transcription by RNA polymerase II PMID:11018017
acts_upstream_of_or_within GO:0055072 iron ion homeostasis PMID:11018017
acts_upstream_of_or_within GO:0008283 cell population proliferation PMID:11018017
enables GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:11018017
located_in GO:0005634 nucleus PMID:11018017
part_of GO:0005667 transcription factor complex PMID:11018017
PR:000026055
hMYC/iso:1/Phos:3
Ser-62/Ser-71, MOD:00046 		acts_upstream_of_or_within GO:0045766 positive regulation of angiogenesis PMID:12676581
located_in GO:0005634 nucleus PMID:12676581
PR:000026054
hMYC/iso:1/Phos:2
Thr-58, MOD:00047|Ser-62, MOD:00046 		enables NOT GO:0003700 DNA-binding transcription factor activity PMID:7623799
PR:000026053
mMYC/iso:1/Phos:2
Thr-58, MOD:00047|Ser-62, MOD:00046 		located_in GO:0005634 nucleus PMID:14563837, PMID:15503302
PR:000036448
hMYC/iso:1/Phos:1
Ser-62, MOD:00046 		enables GO:0005515 protein binding with PR:O15169-1 hAXIN1/iso:1 PMID:19131971
PR:000026051
hMYC/iso:1/OGlyco:1
Thr-58, MOD:00806 		acts_upstream_of_or_within GO:0006357 regulation of transcription by RNA polymerase II PMID:11904304
enables GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:11904304
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000026033 hMYC/iso:1/Ac:1
Lys-143/Lys-157/Lys-275/Lys-317/Lys-323/Lys-371, MOD:00394
PMID:16126174
PR:000026052 mMYC/iso:1/Phos:1
Ser-62, MOD:00046
PMID:11018017
PR:000026053 mMYC/iso:1/Phos:2
Thr-58, MOD:00047|Ser-62, MOD:00046
PMID:14563837, PMID:15503302
PR:000026055 hMYC/iso:1/Phos:3
Ser-62/Ser-71, MOD:00046
PMID:12676581
PR:P01108-1 mMYC/iso:1

PMID:15503302, PMID:16908182

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