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Protein Ontology Report - RIPK1

PR:000014022 - http://purl.obolibrary.org/obo/PR_000014022
Ontology Information
PRO ID PR:000014022 Show OBO stanza / PAF
PRO name receptor-interacting serine/threonine-protein kinase 1
Synonyms
PRO-short-label: EXACT: RIPK1
Gene-based: RELATED: RIP | RIP1 | Rinp
Other: EXACT: RIP-1 | cell death protein RIP | receptor-interacting protein 1 | serine/threonine-protein kinase RIP
Definition A protein that is a translation product of the human RIPK1 gene or a 1:1 ortholog thereof. [PRO:DNx]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 2
sequence 1 organism-sequence 3
modification 3 organism-modification 4
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

RIPK1 forms found in complexes
RIPK1 Component Complexes
PR:000036051 hRIPK1/K63polyUbiq:1 PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:000036051 hRIPK1/K63polyUbiq:1 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036051 hRIPK1/K63polyUbiq:1 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036051 hRIPK1/K63polyUbiq:1 PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:000036107 mRIPK1/K63polyUbiq:1 PR:000036114 IkappaB kinase:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000036107 mRIPK1/K63polyUbiq:1 PR:000036117 pIKBK:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000036107 mRIPK1/K63polyUbiq:1 PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036107 mRIPK1/K63polyUbiq:1 PR:000036111 K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:Q13546 hRIPK1 PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)
PR:Q13546 hRIPK1 PR:000028435 TRADD:TRAF2:RIP1:FADD:caspase-8 complex (human)
PR:Q13546 hRIPK1 PR:000028434 TRAF2:TRADD:RIP1 complex (human)
PR:Q13546 hRIPK1 PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)
PR:Q13546 hRIPK1 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
PR:Q13546 hRIPK1 PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)
PR:Q13546 hRIPK1 PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:Q13546 hRIPK1 PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q13546 hRIPK1 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:Q13546 hRIPK1 PR:000037334 rip1:ticam1:activated TLR3 complex (human)
PR:Q13546 hRIPK1 PR:000028437 TRAF2:TRADD:RIP1:FADD (human)
PR:Q60855 mRIPK1 PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:Q60855 mRIPK1 PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037366
fadd:rip1:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037364
IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000036053
IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_26016
PR:000036051
hRIPK1/K63polyUbiq:1
Lys-377, PR:000044772 		located_in GO:0005737 cytoplasm Reactome:REACT_26236
PR:000036049
K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_25755
PR:000036060
pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
enables GO:0004197 cysteine-type endopeptidase activity Reactome:REACT_151344
located_in GO:0010008 endosome membrane Reactome:REACT_151344
PR:000036649
hRIPK1/iso:1/Ubiq:1
enables GO:0005515 protein binding with PR:Q8C669 mPELI1 PMID:19734906
PR:000037368
pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000036024
rip1:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_25948
PR:000036058
rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_151344
PR:000037362
K63-pUb-rip1:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037334
rip1:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037336
rip1:rip3:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000036101
rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005737 cytoplasm PR:000036051 hRIPK1/K63polyUbiq:1
Lys-377, PR:000044772
Reactome:REACT_26236
GO:0010008 endosome membrane PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25948
PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25755
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26016
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_151344
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_151344
PR:000037334 rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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