Protein Ontology Report - LPSR:4 PR:000025498 - http://purl.obolibrary.org/obo/PR_000025498

Ontology Information
PRO ID	PR:000025498 Show OBO stanza
PRO name	lipopolysaccharide receptor complex 4
Synonyms	PRO-short-label: EXACT: LPSR:4
Definition	A lipopolysaccharide receptor complex that contains the soluble form of CD14, and the lipopolysaccharide (LPS) bound to LY96(MD-2). [PMID:1281215, PMID:16176659, PMID:7681988]
Comment	The soluble form of CD14 is able to transfer the lipopolysaccharide to MD-2 in the tissues where the membrane form is absent.
PRO Category	complex
Parent	GO:0046696 lipopolysaccharide receptor complex
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Independent Organism-Specific Category Number of Terms Category Number of Terms complex 1 organism-complex 1
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Complex Forms Display Category: All All complex organism-complex
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits

Complex PRO ID Name Short Label Definition Number in Complex PR:000025498 PR:000003299 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 LY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed glycosylated form that has been N-glycosylated at positions equivalent to Asn-26 and Asn-114 of the amino acid sequence represented by UniProtKB:Q9Y6Y9-1. Example: UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:17569869, PRO:CNA, PRO:DAN, TLR:AMM] PR:000025492 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 TLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1 that is the mature N-glycosylated form. Example: UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480] PR:000002147 CD14 molecule isoform 1 cleaved 2 soluble form CD14/iso:1/Clv:2/soluble A CD14 molecule isoform 1 cleaved 2 that lacks the GPI-anchor. [PMID:2779588] CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] PR:000037479 PR:000025786 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human) hLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:11706042, PMID:17569869, TLR:AMM] 2 PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human) hTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480] 2 PR:000035703 CD14 molecule isoform 1 cleaved 2 soluble form (human) hCD14/iso:1/Clv:2/soluble A CD14 molecule isoform 1 cleaved 2 soluble form in human. UniProtKB:P08571-1, 20-345. [PRO:DNx, UniProtKB:P08571] 2 CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2

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