PRO Entry Report - PR:000025773

Complex Forms Complex Subunits Annotations

Ontology Information

PRO ID

PR:000025773 Show OBO stanza / PAF / GPI

PRO name

lipopolysaccharide receptor complex 3 (human)

Synonyms

PRO-short-label:	EXACT:	h(LPSR:3)
Other:	BROAD:	TLR4:MD2:LPS:CD14 (human)

Definition

A lipopolysaccharide receptor complex 3 whose components are encoded in the genome of human. [PMID:11274165, PRO:VS]

PRO Category

organism-complex

Parent

PR:000025497 lipopolysaccharide receptor complex 3

Taxon

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Specific
Category	Number of Terms
organism-complex	3

Term Hierarchy Visualization

DAG

OLS

Related Cross References
DB identifiers	Reactome:R-HSA-166850, Reactome:R-HSA-2201299

Complex Forms

PRO ID & Category Annotation Subunits	Name	Short Label	Definition & Comment

Complex Subunits

Complex	PRO ID	Name	Short Label	Definition	Number in Complex
PR:000025773	PR:000025786	lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)	hLY96/iso:1/SigPep-/NGlyco:1	A lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:11706042, PMID:17569869, TLR:AMM]	2
	PR:000025787	Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)	hTLR4/iso:1/SigPep-/NGlyco:1	A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480]	2
	PR:000035702	CD14 molecule isoform 1 cleaved 2 GPI-anchored form (human)	hCD14/iso:1/Clv:2/anchored	A CD14 molecule isoform 1 cleaved 2 GPI-anchored form in human. UniProtKB:P08571-1, 20-345, Asn-345, MOD:00167. [Reactome:R-HSA-166033, Reactome:R-HSA-2201284]	2
	CHEBI:16412	lipopolysaccharide	lipopolysaccharide	Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]	2

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:000036137 lipopolysaccharide receptor complex 3; endosome membrane (human)	acts_upstream_of_or_within	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
	located_in	GO:0010008 endosome membrane	Reactome:REACT_6894
PR:000036136 lipopolysaccharide receptor complex 3; plasma membrane (human)	acts_upstream_of_or_within	GO:0002755 MyD88-dependent toll-like receptor signaling pathway	Reactome:REACT_6894
	located_in	GO:0005886 plasma membrane	Reactome:REACT_6894
PR:000025773 lipopolysaccharide receptor complex 3 (human)	acts_upstream_of_or_within	GO:0034142 toll-like receptor 4 signaling pathway	Reactome:REACT_6894

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005886 plasma membrane	PR:000036136 lipopolysaccharide receptor complex 3; plasma membrane (human)	Reactome:REACT_6894
GO:0010008 endosome membrane	PR:000036137 lipopolysaccharide receptor complex 3; endosome membrane (human)	Reactome:REACT_6894

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