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Protein Ontology Report - hSMAD2/iso:Long/Phos:1

PR:000025934 - http://purl.obolibrary.org/obo/PR_000025934
Ontology Information
PRO ID PR:000025934 Show OBO stanza / PAF / GPI
PRO name smad2 isoform Long phosphorylated 1 (human)
Synonyms
PRO-short-label: EXACT: hSMAD2/iso:Long/Phos:1
PRO-proteoform-std: EXACT: UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046
Definition A smad2 isoform Long phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046. [PMID:8980228, PMID:9346966]
Comment Kinase=("TGFBR1"; PR:000025963; Ser-465/Ser-467).
PRO Category organism-modification
Parent PR:000000650 smad2 isoform Long phosphorylated 1
Taxon NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hSMAD2/iso:Long/Phos:1 forms found in complexes
hSMAD2/iso:Long/Phos:1 Component Complexes
PR:000025934 hSMAD2/iso:Long/Phos:1 PR:000025951 smad2-smad4-ski protein complex 1 (human)
PR:000025934 hSMAD2/iso:Long/Phos:1 PR:000025933 smad2-smad4 protein complex 1 (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000025934
hSMAD2/iso:Long/Phos:1
Ser-465/Ser-467, MOD:00046 		acts_upstream_of_or_within GO:0006355 regulation of DNA-templated transcription PMID:15690394, PMID:9689110
acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209, PMID:8980228
acts_upstream_of_or_within GO:0007183 SMAD protein complex assembly PMID:9346966
acts_upstream_of_or_within GO:0007165 signal transduction PMID:8752209, PMID:8980228, PMID:9346966
enables GO:0003713 transcription coactivator activity PMID:9689110
enables GO:0046332 SMAD binding with PR:Q13485 hSMAD4 PMID:9311995
enables GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8980228, PMID:9346966
located_in GO:0005634 nucleus PMID:9006934, PMID:9346966
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000025934 hSMAD2/iso:Long/Phos:1
Ser-465/Ser-467, MOD:00046
PMID:9006934, PMID:9346966

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