PRO Entry Report - PR:000025947

Complex Forms Complex Subunits Annotations

Ontology Information

PRO ID

PR:000025947 Show OBO stanza / PAF / GPI

PRO name

smad2-smad4 protein complex 4 (human)

Synonyms

PRO-short-label:

EXACT:

h(SMAD2:SMAD4):4

Definition

A smad2-smad4 protein complex 4 whose components are encoded in the genome of human. [PMID:11027280]

PRO Category

organism-complex

Parent

PR:000025970 smad2-smad4 protein complex 4

Taxon

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Specific
Category	Number of Terms
organism-complex	1

Term Hierarchy Visualization

DAG

OLS

Complex Forms

PRO ID & Category Annotation Subunits	Name	Short Label	Definition & Comment

Complex Subunits

Complex	PRO ID	Name	Short Label	Definition	Number in Complex
PR:000025947	PR:Q13485-1	mothers against decapentaplegic homolog 4 isoform 1 (human)	hSMAD4/iso:1	A smad4 isoform 1 that is encoded in the genome of human. [PRO:CNA]
PR:000025947	PR:000025936	smad2 isoform Long phosphorylated 3 (human)	hSMAD2/iso:Long/Phos:3	A smad2 isoform Long phosphorylated 3 in human. This form is phosphorylated on a [S/T] residue within the MH1-MH2 domain linker region, in addition to the two last Ser residues of the SSxS C-terminal motif. UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046. [PMID:11027280]

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:000025947 smad2-smad4 protein complex 4 (human)	acts_upstream_of_or_within	GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway	PMID:11027280
PR:000025947 smad2-smad4 protein complex 4 (human)	located_in	GO:0005737 cytoplasm	PMID:11027280

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005737 cytoplasm	PR:000025947 smad2-smad4 protein complex 4 (human)	PMID:11027280

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