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Protein Ontology Report - (SMAD2:SMAD4):4

PR:000025970 - http://purl.obolibrary.org/obo/PR_000025970
Ontology Information
PRO ID PR:000025970 Show OBO stanza / PAF
PRO name smad2-smad4 protein complex 4
Synonyms
PRO-short-label: EXACT: (SMAD2:SMAD4):4
Definition A smad2-smad4 protein complex that contains smad4 and smad2 phosphorylated on a [S/T] residue within the MH1-MH2 domain linker region in response to decorin-induced Ca(2+) signaling. [PMID:11027280]
PRO Category complex
Parent GO:0071144 heteromeric SMAD protein complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000025947 PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human) hSMAD4/iso:1 A smad4 isoform 1 that is encoded in the genome of human. [PRO:CNA]
PR:000025936 smad2 isoform Long phosphorylated 3 (human) hSMAD2/iso:Long/Phos:3 A smad2 isoform Long phosphorylated 3 in human. This form is phosphorylated on a [S/T] residue within the MH1-MH2 domain linker region, in addition to the two last Ser residues of the SSxS C-terminal motif. UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046. [PMID:11027280]
PR:000025970 PR:000000366 smad4 isoform 1 SMAD4/iso:1 A smad4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13485-1 or a 1:1 ortholog thereof. [PRO:CNA, PRO:DAN]
PR:000000652 smad2 isoform Long phosphorylated 3 SMAD2/iso:Long/Phos:3 A smad2 isoform Long phosphorylated form in which the phosphorylation occurs at a [S/T] residue within the MH1-MH2 domain linker region in response to decorin-induced Ca(2+) signaling. [PMID:11027280]


Functional Annotation
PRO Term GO Annotation Evidence
PR:000025947
smad2-smad4 protein complex 4 (human)
acts_upstream_of_or_within GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:11027280
located_in GO:0005737 cytoplasm PMID:11027280
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005737 cytoplasm PR:000025947 smad2-smad4 protein complex 4 (human)

PMID:11027280

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