Protein Ontology Report - TAK1 kinase complex PR:000027077 - http://purl.obolibrary.org/obo/PR_000027077

Ontology Information
PRO ID	PR:000027077 Show OBO stanza / PAF
PRO name	TAK1 kinase complex
Synonyms	Other: RELATED: TAK1-TAB1-TAB2-TAB3
Definition	A protein-containing complex that possesses protein kinase activity and activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases in response to TRAF6 signaling. It comprises the catalytic subunit TAK1 complexed to the regulatory subunits, termed TABs (TAK1-binding subunit). [PMID:16410796, PMID:17496917, PMID:18021073, PRO:CNA]
Comment	Requested GO term.
PRO Category	complex
Parent	GO:0032991 protein-containing complex
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Independent Organism-Specific Category Number of Terms Category Number of Terms complex 2 organism-complex 3
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Complex Forms Display Category: All All complex organism-complex
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits

Complex PRO ID Name Short Label Definition Number in Complex PR:000027102 PR:Q62073 mitogen-activated protein kinase kinase kinase 7 (mouse) mMAP3K7 A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of mouse. [OMA:Q62073, PRO:CNA] PR:Q8CF89 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (mouse) mTAB1 A TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 that is encoded in the genome of mouse. [OMA:Q8CF89, PRO:CNA] PR:000027101 mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 (mouse) fam:mTAB2-mTAB3 A mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 that is encoded in the genome of mouse. [PMID:15327770, PRO:CNA] PR:000035730 PR:O43318 mitogen-activated protein kinase kinase kinase 7 (human) hMAP3K7 A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43318] 1 PR:Q15750 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (human) hTAB1 A TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 that is encoded in the genome of human. [PRO:CNA] 1 PR:000027103 mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 (human) fam:hTAB2-hTAB3 A mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 that is encoded in the genome of human. [PMID:15327770, PRO:CNA] 1 PR:000027105 PR:Q62073 mitogen-activated protein kinase kinase kinase 7 (mouse) mMAP3K7 A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of mouse. [OMA:Q62073, PRO:CNA] PR:Q99K90 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (mouse) mTAB2 A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 that is encoded in the genome of mouse. [OMA:Q99K90, PRO:CNA] PR:Q8CF89 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (mouse) mTAB1 A TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 that is encoded in the genome of mouse. [OMA:Q8CF89, PRO:CNA]

Functional Annotation PRO Centric View GO Centric View
PRO Term GO Annotation Evidence PR:000035730 TAK1 kinase complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222 acts_upstream_of_or_within GO:0038095 Fc-epsilon receptor signaling pathway Reactome:REACT_163936

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