Protein Ontology Report - hMAP3K7 PR:O43318 - http://purl.obolibrary.org/obo/PR_O43318

This page represents a class of proteins encompassing all the protein products of the MAP3K7 gene in Homo sapiens.

Ontology Information
PRO ID	PR:O43318 Show OBO stanza / PAF / GPI
PRO name	mitogen-activated protein kinase kinase kinase 7 (human)
Synonyms	PRO-short-label: EXACT: hMAP3K7 Gene-based: RELATED: MAP3K7 | TAK1 Other: EXACT: TGF-beta-activated kinase 1 (human) | transforming growth factor-beta-activated kinase 1 (human)
Definition	A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43318]
PRO Category	organism-gene
Parent	PR:000003158 mitogen-activated protein kinase kinase kinase 7
Gene Template	HGNC:6859 MAP3K7
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 4 organism-modification 5
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	DTO:03100289, Reactome:R-HSA-168156, Reactome:R-HSA-450315, Reactome:R-HSA-9012677, UniProtKB:O43318

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hMAP3K7 forms found in complexes

hMAP3K7 Component Complexes PR:000035736 hMAP3K7/Phos:1 PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human) PR:000035736 hMAP3K7/Phos:1 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) PR:000035736 hMAP3K7/Phos:1 PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human) PR:O43318 hMAP3K7 PR:000035730 TAK1 kinase complex (human) PR:O43318 hMAP3K7 PR:000028440 TAB2/TAK1 complex (human) PR:O43318 hMAP3K7 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) PR:O43318 hMAP3K7 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_26039 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_26036 located_in GO:0010008 endosome membrane Reactome:REACT_26036 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000035730 TAK1 kinase complex (human) acts_upstream_of_or_within GO:0038095 Fc-epsilon receptor signaling pathway Reactome:REACT_163936 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222 PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human) acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_23131 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_23131 located_in GO:0005829 cytosol Reactome:REACT_23131 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005829 cytosol PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human) Reactome:REACT_23131 GO:0010008 endosome membrane PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_26036 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_26039 PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783

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