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Protein Ontology Report - free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)

PR:000037338 - http://purl.obolibrary.org/obo/PR_000037338
Ontology Information
PRO ID PR:000037338 Show OBO stanza / PAF / GPI
PRO name free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
Synonyms
Other: RELATED: activated TLR3:TRIF:K63-pUb-TRAF6:free K63-linked pUb:activated TAK1 complex (human)
Definition A free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex whose components are encoded in the genome of human. [PRO:VS, Reactome:R-HSA-936946]
Comment Requested by=TLR.
PRO Category organism-complex
Parent PR:000037337 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037338 PR:Q8IUC6 TIR domain-containing adapter molecule 1 (human) hTICAM1 A TIR domain-containing adapter molecule 1 that is encoded in the genome of human. [PRO:CNA] 2
PR:Q15750 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (human) hTAB1 A TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 that is encoded in the genome of human. [PRO:CNA] 2
PR:000035736 mitogen-activated protein kinase kinase kinase 7 phosphorylated 1 (human) hMAP3K7/Phos:1 A mitogen-activated protein kinase kinase kinase 7 phosphorylated 1 in human. UniProtKB:O43318, Thr-184/Thr-187, MOD:00047. [PRO:DNx, UniProtKB:O43318] 2
PR:000037305 Toll-like receptor 3, signal peptide removed form (human) hTLR3/SigPep- A Toll-like receptor 3, signal peptide removed form in human. Example: UniProtKB:O15455-1, 24-904. [PMID:15340161, PRO:CNA, Reactome:R-HSA-1678955, Reactome:R-HSA-1679057, Reactome:R-HSA-167941, Reactome:R-HSA-2000341] 2
PR:000035714 TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human) hTRAF6/K63polyUbiq:1 A TNF receptor-associated factor 6 K63-polyubiquitinated 1 in human. UniProtKB:Q9Y4K3, Lys-124, PR:000044772. [PRO:DAN, UniProtKB:Q9Y4K3] 2
PR:000035732 K63-polyubiquitin (human) hK63polyUbiq A K63-polyubiquitin in human. [Reactome:R-HSA-450152, Reactome:R-HSA-5682839, Reactome:R-HSA-6782513] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1


Functional Annotation
PRO Term GO Annotation Evidence
PR:000037338
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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