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Protein Ontology Report - TAK1 kinase complex

PR:000027077 - http://purl.obolibrary.org/obo/PR_000027077
Ontology Information
PRO ID PR:000027077 Show OBO stanza / PAF
PRO name TAK1 kinase complex
Synonyms
Other: RELATED: TAK1-TAB1-TAB2-TAB3
Definition A protein-containing complex that possesses protein kinase activity and activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases in response to TRAF6 signaling. It comprises the catalytic subunit TAK1 complexed to the regulatory subunits, termed TABs (TAK1-binding subunit). [PMID:16410796, PMID:17496917, PMID:18021073, PRO:CNA]
Comment Requested GO term.
PRO Category complex
Parent GO:0032991 protein-containing complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 2 organism-complex 3
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000027102 PR:Q62073 mitogen-activated protein kinase kinase kinase 7 (mouse) mMAP3K7 A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of mouse. [OMA:Q62073, PRO:CNA]
PR:Q8CF89 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (mouse) mTAB1 A TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 that is encoded in the genome of mouse. [OMA:Q8CF89, PRO:CNA]
PR:000027101 mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 (mouse) fam:mTAB2-mTAB3 A mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 that is encoded in the genome of mouse. [PMID:15327770, PRO:CNA]
PR:000035730 PR:O43318 mitogen-activated protein kinase kinase kinase 7 (human) hMAP3K7 A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43318] 1
PR:Q15750 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (human) hTAB1 A TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 that is encoded in the genome of human. [PRO:CNA] 1
PR:000027103 mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 (human) fam:hTAB2-hTAB3 A mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 that is encoded in the genome of human. [PMID:15327770, PRO:CNA] 1
PR:000027105 PR:Q62073 mitogen-activated protein kinase kinase kinase 7 (mouse) mMAP3K7 A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of mouse. [OMA:Q62073, PRO:CNA]
PR:Q99K90 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (mouse) mTAB2 A TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 that is encoded in the genome of mouse. [OMA:Q99K90, PRO:CNA]
PR:Q8CF89 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (mouse) mTAB1 A TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 that is encoded in the genome of mouse. [OMA:Q8CF89, PRO:CNA]


Functional Annotation
PRO Term GO Annotation Evidence
PR:000035730
TAK1 kinase complex (human)
acts_upstream_of_or_within GO:0038095 Fc-epsilon receptor signaling pathway Reactome:REACT_163936
acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809

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