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Protein Ontology Report - IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex

PR:000037363 - http://purl.obolibrary.org/obo/PR_000037363
Ontology Information
PRO ID PR:000037363 Show OBO stanza / PAF
PRO name IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex
Synonyms
Other: EXACT: activated TLR3:TRIF:K63-pUb-RIP1:IKKcomplex
Definition A protein-containing complex that is composed of activated Toll-like receptor 3 (TLR3), Ticam1 (TRIF), the death receptor RIPK1 (RIP1) cross-linked to K63-linked polyubiquitin, and the IKK complex (consisting of IKKA, IKKB and NEMO). [PMID:15064760, PMID:15814722, PMID:16115877, Reactome:R-HSA-937030]
Comment Requested by=TLR.
PRO Category complex
Parent GO:0032991 protein-containing complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037364 PR:O14920 inhibitor of nuclear factor kappa-B kinase subunit beta (human) hIKBKB An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14920] 1
PR:O15111 inhibitor of nuclear factor kappa-B kinase subunit alpha (human) hCHUK An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15111] 1
PR:Q8IUC6 TIR domain-containing adapter molecule 1 (human) hTICAM1 A TIR domain-containing adapter molecule 1 that is encoded in the genome of human. [PRO:CNA] 2
PR:Q9Y6K9 NF-kappa-B essential modulator (human) hIKBKG An NF-kappa-B essential modulator that is encoded in the genome of human. [PRO:DNx] 1
PR:000036051 receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 (human) hRIPK1/K63polyUbiq:1 A receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 in human. UniProtKB:Q13546, Lys-377, PR:000044772. [Reactome:R-HSA-937021] 2
PR:000037305 Toll-like receptor 3, signal peptide removed form (human) hTLR3/SigPep- A Toll-like receptor 3, signal peptide removed form in human. Example: UniProtKB:O15455-1, 24-904. [PMID:15340161, PRO:CNA, Reactome:R-HSA-1678955, Reactome:R-HSA-1679057, Reactome:R-HSA-167941, Reactome:R-HSA-2000341] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1


Functional Annotation
PRO Term GO Annotation Evidence
PR:000037364
IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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