PRO Entry Report - PR:000045370

Protein Forms Annotations

Ontology Information

PRO ID

PR:000045370 Show OBO stanza / PAF / GPI

PRO name

cyclin-dependent kinase inhibitor 1B isoform 1 unphosphorylated 2 (human)

Synonyms

PRO-short-label:	EXACT:	hCDKN1B/iso:1/UnPhos:2
PRO-proteoform-std:	EXACT:	UniProtKB:P46527-1, Tyr-88, PR:000026291

Definition

A cyclin-dependent kinase inhibitor 1B isoform 1 (human) that lacks phosphorylation at Tyr-88. UniProtKB:P46527-1, Tyr-88, PR:000026291. [PRO:CNA]

PRO Category

organism-modification

Parent

PR:P46527-1 cyclin-dependent kinase inhibitor 1B isoform 1 (human)

Taxon

Term Hierarchy Visualization

DAG

OLS

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:000045370 hCDKN1B/iso:1/UnPhos:2 Tyr-88, PR:000026291	acts_upstream_of_or_within	GO:0051318 G1 phase	PMID:17254966
	acts_upstream_of_or_within	GO:0008285 negative regulation of cell population proliferation	PMID:12244301
	enables	GO:0005515 protein binding with PR:P31749 hAKT1	PMID:12244301
	enables	GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity	PMID:17254966
	enables	GO:0044877 protein-containing complex binding with PR:000026741 cyclin D1:Cdk4 (human)	PMID:17254966
	located_in	GO:0005634 nucleus	PMID:12244301

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005634 nucleus	PR:000045370 hCDKN1B/iso:1/UnPhos:2 Tyr-88, PR:000026291	PMID:12244301

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