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Protein Ontology Report - hIgG4/circulating

PR:000050312 -
Ontology Information
PRO ID PR:000050312 Show OBO stanza / GPI
PRO name IgG4 immunoglobulin complex, circulating (human)
PRO-short-label: EXACT: hIgG4/circulating
Other: EXACT: IgG4 antibody (human)
BROAD: IgG antibody (human)
Definition An IgG4 immunoglobulin complex (human) that is composed of two immunoglobulin heavy chains of an IgG4 isotype of the secretory isoform and two immunoglobulin light chains (kappa or lambda), held together by disulfide bonds and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. Note that secreted IgG4 often undergoes half-molecule exchange (exchange of one heavy chain-light chain arm for another) to form bivalent complexes (two independent binding sites) that are functionally molevalent in most biological situations. [GOC:add, PMID:25368619, PRO:ADD]
Comment Requested by=HIPC.Requested by=CL.
PRO Category organism-complex
Parent PR:000050308 IgG4 immunoglobulin complex (human)
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Category Number of Terms
organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000050312 PR:000050183 immunoglobulin light chain protein (human) hIgL An immunoglobulin light chain protein that is encoded in the genome of human. [PRO:DAN] 2
PR:000050300 IgG4 heavy chain protein, secretory isoform (human) hIgHG4/iso:secretory An IgG4 heavy chain protein (human) that is a translation product of some mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA. [GOC:add, PMID:17496345, PMID:9185563, PRO:ADD, PRO:DAN] 2