Protein Ontology Report - hPML PR:P29590 - http://purl.obolibrary.org/obo/PR_P29590

This page represents a class of proteins encompassing all the protein products of the PML gene in Homo sapiens.

Ontology Information
PRO ID	PR:P29590 Show OBO stanza / PAF / GPI
PRO name	protein PML (human)
Synonyms	PRO-short-label: EXACT: hPML Gene-based: RELATED: MYL | PML | PP8675 | RNF71 | TRIM19 Other: EXACT: E3 SUMO-protein ligase PML (human) | RING finger protein 71 (human) | RING-type E3 SUMO transferase PML (human) | promyelocytic leukemia protein (human) | tripartite motif-containing protein 19 (human)
Definition	A transcription factor PML that is encoded in the genome of human. [PRO:CNA, UniProtKB:P29590]
PRO Category	organism-gene
Parent	PR:000026474 transcription factor PML
Gene Template	HGNC:9113 PML
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 12 organism-modification 1
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	Reactome:R-HSA-1031706, Reactome:R-HSA-5624327, UniProtKB:P29590

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:P29590-3 hPML/iso:3 acts_upstream_of_or_within GO:0030578 PML body organization PMID:10779416 acts_upstream_of_or_within GO:0006915 apoptotic process PMID:9583681 acts_upstream_of_or_within GO:0030308 negative regulation of cell growth PMID:9583681 acts_upstream_of_or_within GO:0030308 negative regulation of cell growth PMID:7935403 acts_upstream_of_or_within GO:0030308 negative regulation of cell growth PMID:9395203 acts_upstream_of_or_within GO:0045930 negative regulation of mitotic cell cycle PMID:9395203 acts_upstream_of_or_within GO:0051726 regulation of cell cycle PMID:9583681 enables GO:0046982 protein heterodimerization activity PMID:7935403 enables GO:0005515 protein binding with PR:Q64127 mTRIM24 PMID:10610177 enables GO:0005515 protein binding with PR:P04489 E4orf3 (ADE05) PMID:16501113 enables GO:0005515 protein binding with PR:P45481 mCREBBP PMID:10610177 enables GO:0005515 protein binding with PR:P06400 hRB1 PMID:9448006 located_in GO:0031965 nuclear membrane PMID:16778193 located_in GO:0005634 nucleus PMID:9294197 located_in GO:0005737 cytoplasm PMID:16778193 PR:P29590-2 hPML/iso:2 acts_upstream_of_or_within GO:0002230 positive regulation of defense response to virus by host PMID:16873256 located_in GO:0005634 nucleus PMID:16778193 located_in GO:0005737 cytoplasm PMID:16778193 PR:P29590-1 hPML/iso:1 enables GO:0005515 protein binding with PR:Q13164 hMAPK7 PMID:20832753 located_in GO:0005737 cytoplasm PMID:16778193 located_in GO:0005634 nucleus PMID:16778193 located_in GO:0005737 cytoplasm PMID:9885291 PR:P29590-5 hPML/iso:5 acts_upstream_of_or_within GO:0051726 regulation of cell cycle PMID:12773567 acts_upstream_of_or_within GO:0032938 negative regulation of translation in response to oxidative stress PMID:16915281 acts_upstream_of_or_within GO:0050821 protein stabilization PMID:12773567 acts_upstream_of_or_within GO:0030308 negative regulation of cell growth PMID:9448006 acts_upstream_of_or_within GO:0006915 apoptotic process PMID:11080164 acts_upstream_of_or_within GO:0031065 positive regulation of histone deacetylation PMID:11259576 acts_upstream_of_or_within GO:0045892 negative regulation of DNA-templated transcription PMID:9448006 acts_upstream_of_or_within GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage PMID:12402044 acts_upstream_of_or_within GO:0006605 protein targeting PMID:11080164 acts_upstream_of_or_within GO:0006605 protein targeting PMID:15195100 enables GO:0005515 protein binding with PR:Q05516 hZBTB16 PMID:9294197 enables GO:0003713 transcription coactivator activity PMID:11080164 enables GO:0005515 protein binding with PR:Q92547 hTOPBP1 PMID:12773567 enables GO:0005515 protein binding with PR:Q05516 hZBTB16 PMID:9294197 enables GO:0003713 transcription coactivator activity PMID:15626733 enables GO:0005515 protein binding with PR:Q00987 hMDM2 PMID:12915590 enables GO:0005515 protein binding with PR:P06400 hRB1 PMID:9448006 enables GO:0005515 protein binding with PR:P04637 hTP53 PMID:11080164 enables GO:0005515 protein binding with PR:O15379 hHDAC3 PMID:11259576 enables GO:0005515 protein binding with PR:Q00987 hMDM2 PMID:12915590 enables GO:0005515 protein binding with PR:P62913 hRPL11 PMID:15195100 enables GO:0005515 protein binding with PR:Q92769 hHDAC2 PMID:11259576 enables GO:0005515 protein binding with PR:Q13547 hHDAC1 PMID:11259576 enables GO:0005515 protein binding with PR:O96017 hCHEK2 PMID:12402044 located_in GO:0005737 cytoplasm PMID:16778193 located_in GO:0005730 nucleolus PMID:16778193 located_in GO:0016363 nuclear matrix PMID:11080164 located_in GO:0016605 PML body PMID:9448006 PR:P29590-4 hPML/iso:4 acts_upstream_of_or_within GO:0030578 PML body organization PMID:8643677 acts_upstream_of_or_within GO:0002230 positive regulation of defense response to virus by host PMID:16873257 enables GO:0008270 zinc ion binding PMID:7729428 enables GO:0005515 protein binding with PR:P23769 hGATA2 PMID:10938104 enables GO:0005515 protein binding with PR:P14373 hTRIM27 PMID:9570750 enables GO:0005515 protein binding with PR:Q9UER7-1 hDAXX/iso:1 PMID:10669754 enables GO:0005515 protein binding with PR:P63073 mEIF4E PMID:11500381 enables GO:0005515 protein binding with PR:P63165 hSUMO1 PMID:9885291 enables GO:0005515 protein binding with PR:P63279 hUBE2I PMID:9885291 enables GO:0005515 protein binding with PR:Q03014 hHHEX PMID:10597310 enables GO:0050897 cobalt ion binding PMID:7729428 located_in GO:0016605 PML body PMID:9885291 PR:000026480 hPML/iso:1/Phos:1 Ser-403, MOD:00046|Thr-409, MOD:00047 located_in GO:0005634 nucleus PMID:20832753 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0016363 nuclear matrix PR:P29590-5 hPML/iso:5 PMID:11080164 GO:0016605 PML body PR:P29590-4 hPML/iso:4 PMID:9885291 PR:P29590-5 hPML/iso:5 PMID:9448006 GO:0005737 cytoplasm PR:P29590-1 hPML/iso:1 PMID:16778193 PR:P29590-1 hPML/iso:1 PMID:9885291 PR:P29590-2 hPML/iso:2 PMID:16778193 PR:P29590-3 hPML/iso:3 PMID:16778193 PR:P29590-5 hPML/iso:5 PMID:16778193 GO:0005730 nucleolus PR:P29590-5 hPML/iso:5 PMID:16778193 GO:0031965 nuclear membrane PR:P29590-3 hPML/iso:3 PMID:16778193 GO:0005634 nucleus PR:000026480 hPML/iso:1/Phos:1 Ser-403, MOD:00046|Thr-409, MOD:00047 PMID:20832753 PR:P29590-1 hPML/iso:1 PMID:16778193 PR:P29590-2 hPML/iso:2 PMID:16778193 PR:P29590-3 hPML/iso:3 PMID:9294197

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