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Protein Ontology Report - hTGFBR2

PR:P37173 - http://purl.obolibrary.org/obo/PR_P37173
This page represents a class of proteins encompassing all the protein products of the TGFBR2 gene in Homo sapiens.
Ontology Information
PRO ID PR:P37173 Show OBO stanza / PAF / GPI
PRO name TGF-beta receptor type-2 (human)
Synonyms
PRO-short-label: EXACT: hTGFBR2
Gene-based: RELATED: TGFBR2
Other: EXACT: TGF-beta receptor type II (human) | TGF-beta type II receptor (human) | TGFR-2 (human) | TbetaR-II (human) | transforming growth factor-beta receptor type II (human)
Definition A TGF-beta receptor type-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P37173]
PRO Category organism-gene
Parent PR:000000005 TGF-beta receptor type-2
Gene Template HGNC:11773 TGFBR2
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 19
organism-modification 3
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTGFBR2 forms found in complexes
hTGFBR2 Component Complexes
PR:000025962 hTGFBR2/iso:RII-1/SigPep-/Phos:1 PR:000025963 transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000057
hTGFBR2/var:G357W
Gly-357, CHEBI:29954 		associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000051
hTGFBR2/var:R460H
Arg-460, CHEBI:29979 		associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000050
hTGFBR2/var:L308P
Leu-308, CHEBI:50342 		associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15235604
enables NOT GO:0005026 transforming growth factor beta receptor activity, type II PMID:15235604
PR:P37173-2
hTGFBR2/iso:RII-2
acts_upstream_of_or_within GO:0008284 positive regulation of cell population proliferation PMID:7959019
acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:7959019, PMID:8635485
enables GO:0005026 transforming growth factor beta receptor activity, type II PMID:7959019, PMID:8635485
enables GO:0050431 transforming growth factor beta binding PMID:8635485
PR:000000061
hTGFBR2/var:V387M
Val-387, CHEBI:16044 		acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11212236
enables GO:0005026 transforming growth factor beta receptor activity, type II decreased relative to PR:000000409 TGFBR2/iso:RII-1/SigPep- PMID:11212236
located_in GO:0016020 membrane PMID:11212236
PR:000036408
hTGFBR2/iso:RII-1/SigPep-
acts_upstream_of_or_within GO:0007181 transforming growth factor beta receptor complex assembly PMID:1310899, PMID:8774881
acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11483955
enables GO:0005515 protein binding with PR:000000616 TGFB1/iso:1/mature PMID:1310899
enables GO:0005515 protein binding with PR:000000634 TGFB3/iso:1/Clv:1 PMID:1850637
enables GO:0005026 transforming growth factor beta receptor activity, type II PMID:11483955
enables GO:0050431 transforming growth factor beta binding PMID:11850637, PMID:1310899
located_in GO:0016020 membrane PMID:1310899
PR:000000056
hTGFBR2/var:R537C
Arg-537, CHEBI:29950 		associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15235604
enables NOT GO:0005026 transforming growth factor beta receptor activity, type II PMID:15235604
PR:000000005
TGFBR2
acts_upstream_of_or_within GO:0006468 protein phosphorylation PIRSF:PIRSF037393
acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PIRSF:PIRSF037393
acts_upstream_of_or_within GO:0042127 regulation of cell population proliferation PIRSF:PIRSF037393
enables GO:0005515 protein binding PIRSF:PIRSF037393
enables GO:0004672 protein kinase activity PIRSF:PIRSF037393
PR:000000062
hTGFBR2/var:N435S
Asn-435, CHEBI:29999 		acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11212236
enables GO:0005026 transforming growth factor beta receptor activity, type II decreased relative to PR:000000409 TGFBR2/iso:RII-1/SigPep- PMID:11212236
PR:000000063
hTGFBR2/var:V447A
Val-447, CHEBI:46217 		acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11212236
enables GO:0005026 transforming growth factor beta receptor activity, type II decreased relative to PR:000000409 TGFBR2/iso:RII-1/SigPep- PMID:11212236
located_in GO:0016020 membrane PMID:11212236
PR:000000060
hTGFBR2/var:A355P
Ala-355, CHEBI:50342 		acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:15731757
associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15731757
located_in GO:0016020 membrane PMID:15731757
PR:000000054
hTGFBR2/var:R528C
Arg-528, CHEBI:29950 		associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000053
hTGFBR2/var:E526Q
Glu-526, CHEBI:30011 		associated_with_disease_progression DOID:3748 esophagus squamous cell carcinoma PMID:10789724
enables NOT GO:0005026 transforming growth factor beta receptor activity, type II PMID:10789724
PR:000000052
hTGFBR2/var:R460C
Arg-460, CHEBI:29950 		associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000064
hTGFBR2/var:S449F
Ser-449, CHEBI:29997 		associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15235604
enables NOT GO:0005026 transforming growth factor beta receptor activity, type II PMID:15235604
PR:000000065
hTGFBR2/var:L452M
Leu-452, CHEBI:16044 		acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11212236
enables GO:0005026 transforming growth factor beta receptor activity, type II decreased relative to PR:000000409 TGFBR2/iso:RII-1/SigPep- PMID:11212236
PR:000000055
hTGFBR2/var:R528H
Arg-528, CHEBI:29979 		associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000059
hTGFBR2/var:Y336N
Tyr-336, CHEBI:50347 		associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000058
hTGFBR2/var:T315M
Thr-315, CHEBI:16044 		acts_upstream_of_or_within GO:0008284 positive regulation of cell population proliferation PMID:9590282
associated_with_disease_progression DOID:3883 Lynch syndrome PMID:9590282
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0016020 membrane PR:000000060 hTGFBR2/var:A355P
Ala-355, CHEBI:50342
PMID:15731757
PR:000000061 hTGFBR2/var:V387M
Val-387, CHEBI:16044
PMID:11212236
PR:000000063 hTGFBR2/var:V447A
Val-447, CHEBI:46217
PMID:11212236
PR:000036408 hTGFBR2/iso:RII-1/SigPep-

PMID:1310899

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