Protein Ontology Report - hTRAF3 PR:Q13114 - http://purl.obolibrary.org/obo/PR_Q13114

This page represents a class of proteins encompassing all the protein products of the TRAF3 gene in Homo sapiens.

Ontology Information
PRO ID	PR:Q13114 Show OBO stanza / PAF / GPI
PRO name	TNF receptor-associated factor 3 (human)
Synonyms	PRO-short-label: EXACT: hTRAF3 Gene-based: RELATED: CAP-1 | CRAF1 | TRAF3 | TRAFAMN Other: EXACT: CD40 receptor-associated factor 1 (human) | CD40-binding protein (human) | CD40BP (human) | LAP1 (human) | LMP1-associated protein 1 (human) | RING-type E3 ubiquitin transferase TRAF3 (human)
Definition	A TNF receptor-associated factor 3 that is encoded in the genome of human. [PRO:CNA]
PRO Category	organism-gene
Parent	PR:000002289 TNF receptor-associated factor 3
Gene Template	HGNC:12033 TRAF3
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 2 organism-modification 1
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	Reactome:R-HSA-914241, UniProtKB:Q13114

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTRAF3 forms found in complexes

hTRAF3 Component Complexes PR:000036032 hTRAF3/K63polyUbiq+ PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000036032 hTRAF3/K63polyUbiq+ PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) PR:000036032 hTRAF3/K63polyUbiq+ PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000036032 hTRAF3/K63polyUbiq+ PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000036032 hTRAF3/K63polyUbiq+ PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000036032 hTRAF3/K63polyUbiq+ PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000036032 hTRAF3/K63polyUbiq+ PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000036032 hTRAF3/K63polyUbiq+ PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000036032 hTRAF3/K63polyUbiq+ PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) PR:000036032 hTRAF3/K63polyUbiq+ PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000036032 hTRAF3/K63polyUbiq+ PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000036032 hTRAF3/K63polyUbiq+ PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000036032 hTRAF3/K63polyUbiq+ PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000036032 hTRAF3/K63polyUbiq+ PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:Q13114 hTRAF3 PR:000037310 traf3:ticam1:activated TLR3 complex (human) PR:Q13114 hTRAF3 PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:Q13114 hTRAF3 PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:Q13114 hTRAF3 PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:Q13114 hTRAF3 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human) PR:Q13114 hTRAF3 PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:Q13114 hTRAF3 PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:Q13114 hTRAF3 PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_26959 PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_124855 PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_26959 PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_124037 enables GO:0004842 ubiquitin-protein transferase activity Reactome:REACT_124037 located_in GO:0010008 endosome membrane Reactome:REACT_124037 PR:000037310 traf3:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0010008 endosome membrane PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_124037 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_124855 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) Reactome:REACT_26959 PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) Reactome:REACT_26959 PR:000037310 traf3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783

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