Protein Ontology Report - hTRAF6 PR:Q9Y4K3 - http://purl.obolibrary.org/obo/PR_Q9Y4K3

This page represents a class of proteins encompassing all the protein products of the TRAF6 gene in Homo sapiens.

Ontology Information
PRO ID	PR:Q9Y4K3 Show OBO stanza / PAF / GPI
PRO name	TNF receptor-associated factor 6 (human)
Synonyms	PRO-short-label: EXACT: hTRAF6 Gene-based: RELATED: RNF85 | TRAF6 Other: EXACT: E3 ubiquitin-protein ligase TRAF6 (human) | RING finger protein 85 (human) | RING-type E3 ubiquitin transferase TRAF6 (human) | interleukin-1 signal transducer (human)
Definition	A TNF receptor-associated factor 6 that is encoded in the genome of human. [PRO:CNx, UniProtKB:Q9Y4K3]
PRO Category	organism-gene
Parent	PR:000002292 TNF receptor-associated factor 6
Gene Template	HGNC:12036 TRAF6
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 1 organism-modification 1
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	Reactome:R-HSA-166366, Reactome:R-HSA-450272, Reactome:R-HSA-936955, UniProtKB:Q9Y4K3

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTRAF6 forms found in complexes

hTRAF6 Component Complexes PR:000035714 hTRAF6/K63polyUbiq:1 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) PR:000035714 hTRAF6/K63polyUbiq:1 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human) PR:000035714 hTRAF6/K63polyUbiq:1 PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human) PR:000035714 hTRAF6/K63polyUbiq:1 PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human) PR:000035714 hTRAF6/K63polyUbiq:1 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) PR:000035714 hTRAF6/K63polyUbiq:1 PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human) PR:000035714 hTRAF6/K63polyUbiq:1 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) PR:Q9Y4K3 hTRAF6 PR:000037344 traf6:ticam1:activated TLR3 complex (human) PR:Q9Y4K3 hTRAF6 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000035714 hTRAF6/K63polyUbiq:1 Lys-124, PR:000044772 acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_25867 PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human) acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_23131 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_23131 located_in GO:0005829 cytosol Reactome:REACT_23131 PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_26039 PR:000037344 traf6:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_26036 located_in GO:0010008 endosome membrane Reactome:REACT_26036 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human) acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809 acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 located_in GO:0010008 endosome membrane Reactome:REACT_25948 PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human) acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 located_in GO:0010008 endosome membrane Reactome:REACT_6783 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005829 cytosol PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human) Reactome:REACT_23131 GO:0010008 endosome membrane PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_25948 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_25867 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_26036 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_26039 PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037344 traf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783

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