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Protein Ontology report - TEC-type tyrosine-protein kinase
PR:000001967 - http://purl.obolibrary.org/obo/PR_000001967
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000001967   
  PRO nameTEC-type tyrosine-protein kinase 
  Synonyms
Other: EXACT:Tec family kinase
  Definition"A protein with core architecture consisting of a PH domain (Pfam:PF00169), a BTK-type zinc finger (Pfam:PF00779), an SH3 domain (Pfam:PF00018, an SH2 domain (Pfam:PF00017), and a Protein typrosine kinase domain (Pfam:PF07714)." [PRO:WCB] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 10                                        
         Sequence11                                                  Organism-Sequence 17                                        
         Modification2                                                  Organism-Modification 14                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF000602
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000001967

TEC-type tyrosine-protein kinase

TPCN2


"A protein with core architecture consisting of a PH domain (Pfam:PF00169), a BTK-type zinc finger (Pfam:PF00779), an SH3 domain (Pfam:PF00018, an SH2 domain (Pfam:PF00017), and a Protein typrosine kinase domain (Pfam:PF07714)." [PRO:WCB]


gene



PR:000002110

tyrosine-protein kinase BTK

BTK


"A TEC-type tyrosine-protein kinase that is a translation product of the human BTK gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:P35991

tyrosine-protein kinase BTK (mouse)

mBTK


"A tyrosine-protein kinase BTK that is encoded in the genome of mouse." [OMA:P35991, PRO:WCB]


Yes
organism-sequence



PR:P35991-1

tyrosine-protein kinase BTK isoform 1 (mouse)

mBTK/iso:1


"A tyrosine-protein kinase BTK isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


organism-modification



PR:000037482

tyrosine-protein kinase BTK phosphorylated 1 (mouse)

mBTK/Phos:1


"A tyrosine-protein kinase BTK (mouse) that is phosphorylated on two Tyr residues. Site 1 is a Tyr within the Src homology type 1 (SH1) domain and is transphosphorylated by a Src family tyrosine kinase. Site 2 is an autophosphorylation site within the Btk SH3 domain. UniProtKB:P35991, Tyr-223/Tyr-551, MOD:00048." [PMID:9326643]


organism-gene



PR:Q06187

tyrosine-protein kinase BTK (human)

hBTK


"A tyrosine-protein kinase BTK that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q06187]


organism-sequence



PR:Q06187-1

tyrosine-protein kinase BTK isoform BTK-A (human)

hBTK/iso:BTK-A


"A tyrosine-protein kinase BTK isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:Q06187-2

tyrosine-protein kinase BTK isoform BTK-C (human)

hBTK/iso:BTK-C


"A tyrosine-protein kinase BTK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q06187-2." [PRO:DNx, UniProtKB:Q06187]


organism-modification



PR:000044351

tyrosine-protein kinase BTK, initiator methionine removed form (human)

hBTK/InitMet-


"A tyrosine-protein kinase BTK, initiator methionine removed form in human. Example: UniProtKB:Q06187-1, 2-659." [PRO:CNA, UniProtKB:Q06187]


Yes
organism-modification



PR:000046518

tyrosine-protein kinase BTK, initiator methionine removed phosphorylated 2 (human)

hBTK/InitMet-/Phos:2


"A tyrosine-protein kinase BTK, initiator methionine removed form (human) that has been post-translationally modified to include phosphotyrosine at positions 223 and 551 of the amino acid sequence represented by UniProtKB:Q06187. UniProtKB:Q06187, 2-659, Tyr-223/Tyr-551, MOD:00048." [PRO:DNx, Reactome:R-HSA-2424454, Reactome:R-HSA-984807]


organism-modification



PR:000046519

tyrosine-protein kinase BTK, initiator methionine removed phosphorylated 1 (human)

hBTK/InitMet-/Phos:1


"A tyrosine-protein kinase BTK, initiator methionine removed form (human) that has been phosphorylated on the residue at the position equivalent to Tyr-551 of the amino acid sequence represented by UniProtKB:Q06187. UniProtKB:Q06187, 2-659, Tyr-551, MOD:00048." [PRO:DNx, Reactome:R-HSA-2685603]


organism-modification



PR:000045882

tyrosine-protein kinase BTK phosphorylated 1 (human)

hBTK/Phos:1


"A tyrosine-protein kinase BTK (human) that has been phosphorylated on the residue at the position equivalent to Tyr-551 of the amino acid sequence represented by UniProtKB:Q06187-1. Example: UniProtKB:Q06187-1, Tyr-551, MOD:00048." [iPTMnet:Q06187, PMID:11226282, PMID:7565679]


organism-modification



PR:000069637

tyrosine-protein kinase BTK deaminated 1 (human)

hBTK/Deam:1


"A tyrosine-protein kinase BTK (human) that has been deaminated on the residue at the position equivalent to Gln-103 of the amino acid sequence represented by UniProtKB:Q06187-1. Example: UniProtKB:Q06187-1, Gln-103, MOD:00685." [IEDB_epitope:1353605, PRO:DNx]


organism-modification



PR:000070839

tyrosine-protein kinase BTK deaminated 2 (human)

hBTK/Deam:2


"A tyrosine-protein kinase BTK (human) that has been deaminated on the residue at the position equivalent to Asn-381 of the amino acid sequence represented by UniProtKB:Q06187-1. Example: UniProtKB:Q06187-1, Asn-381, MOD:00684." [IEDB_epitope:1376974, PRO:DNx]


organism-modification



PR:000077962

tyrosine-protein kinase BTK methylated 1 (human)

hBTK/Me:1


"A tyrosine-protein kinase BTK (human) that has been methylated on the residue at the position equivalent to Cys-145 of the amino acid sequence represented by UniProtKB:Q06187-1. Example: UniProtKB:Q06187-1, Cys-145, MOD:00660." [IEDB_epitope:1018627, PRO:DNx]


sequence



PR:000002236

tyrosine-protein kinase BTK isoform 1

BTK/iso:1


"A tyrosine-protein kinase BTK that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q06187-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P35991-1

tyrosine-protein kinase BTK isoform 1 (mouse)

mBTK/iso:1


"A tyrosine-protein kinase BTK isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


organism-sequence



PR:Q06187-1

tyrosine-protein kinase BTK isoform BTK-A (human)

hBTK/iso:BTK-A


"A tyrosine-protein kinase BTK isoform 1 that is encoded in the genome of human." [PRO:JAN]


modification



PR:000026589

tyrosine-protein kinase BTK isoform 1, initiator methionine removed form

BTK/iso:1/InitMet-


"A tyrosine-protein kinase BTK isoform 1 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000018724

tyrosine-protein kinase BTK, initiator methionine removed form

BTK/InitMet-


"A tyrosine-protein kinase BTK that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000026589

tyrosine-protein kinase BTK isoform 1, initiator methionine removed form

BTK/iso:1/InitMet-


"A tyrosine-protein kinase BTK isoform 1 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000044351

tyrosine-protein kinase BTK, initiator methionine removed form (human)

hBTK/InitMet-


"A tyrosine-protein kinase BTK, initiator methionine removed form in human. Example: UniProtKB:Q06187-1, 2-659." [PRO:CNA, UniProtKB:Q06187]


Yes
organism-modification



PR:000046518

tyrosine-protein kinase BTK, initiator methionine removed phosphorylated 2 (human)

hBTK/InitMet-/Phos:2


"A tyrosine-protein kinase BTK, initiator methionine removed form (human) that has been post-translationally modified to include phosphotyrosine at positions 223 and 551 of the amino acid sequence represented by UniProtKB:Q06187. UniProtKB:Q06187, 2-659, Tyr-223/Tyr-551, MOD:00048." [PRO:DNx, Reactome:R-HSA-2424454, Reactome:R-HSA-984807]


organism-modification



PR:000046519

tyrosine-protein kinase BTK, initiator methionine removed phosphorylated 1 (human)

hBTK/InitMet-/Phos:1


"A tyrosine-protein kinase BTK, initiator methionine removed form (human) that has been phosphorylated on the residue at the position equivalent to Tyr-551 of the amino acid sequence represented by UniProtKB:Q06187. UniProtKB:Q06187, 2-659, Tyr-551, MOD:00048." [PRO:DNx, Reactome:R-HSA-2685603]


gene



PR:000002111

tyrosine-protein kinase ITK/TSK

ITK


"A TEC-type tyrosine-protein kinase that is a translation product of the human ITK gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:Q03526

tyrosine-protein kinase ITK/TSK (mouse)

mITK


"A tyrosine-protein kinase ITK/TSK that is encoded in the genome of mouse." [OMA:Q03526, PRO:DNx]


organism-sequence



PR:Q03526-1

tyrosine-protein kinase ITK/TSK isoform 1 (mouse)

mITK/iso:1


"A tyrosine-protein kinase ITK/TSK isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


organism-sequence



PR:Q5STT8

tyrosine-protein kinase ITK/TSK isoform 2 (mouse)

mITK/iso:2


"A tyrosine-protein kinase ITK/TSK isoform 2 that is encoded in the genome of mouse." [PRO:JAN]


organism-gene



PR:Q08881

tyrosine-protein kinase ITK/TSK (human)

hITK


"A tyrosine-protein kinase ITK/TSK that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q08881]


organism-sequence



PR:Q08881-1

tyrosine-protein kinase ITK/TSK isoform 1 (human)

hITK/iso:1


"A tyrosine-protein kinase ITK/TSK isoform 2 that is encoded in the genome of human." [PRO:JAN]


organism-modification



PR:000048074

tyrosine-protein kinase ITK/TSK phosphorylated 1 (human)

hITK/Phos:1


"A tyrosine-protein kinase ITK/TSK (human) that has been post-translationally modified to include phosphotyrosine at positions 180 and 512 of the amino acid sequence represented by UniProtKB:Q08881. UniProtKB:Q08881, Tyr-180/Tyr-512, MOD:00048." [PRO:DNx, Reactome:R-HSA-2685616]


organism-modification



PR:000048075

tyrosine-protein kinase ITK/TSK phosphorylated 2 (human)

hITK/Phos:2


"A tyrosine-protein kinase ITK/TSK (human) that has been phosphorylated on the residue at the position equivalent to Tyr-512 of the amino acid sequence represented by UniProtKB:Q08881. UniProtKB:Q08881, Tyr-512, MOD:00048." [PMID:9312162, PRO:DNx, Reactome:R-HSA-422519]


organism-modification



PR:000068201

tyrosine-protein kinase ITK/TSK cysteinylated 1 (human)

hITK/Cyst:1


"A tyrosine-protein kinase ITK/TSK (human) that has been cysteinylated on the residue at the position equivalent to Cys-432 of the amino acid sequence represented by UniProtKB:Q08881. UniProtKB:Q08881, Cys-432, MOD:00765." [IEDB_epitope:1568633, PRO:DNx]


organism-modification



PR:000069845

tyrosine-protein kinase ITK/TSK cysteinylated 2 (human)

hITK/Cyst:2


"A tyrosine-protein kinase ITK/TSK (human) that has been cysteinylated on the residue at the position equivalent to Cys-594 of the amino acid sequence represented by UniProtKB:Q08881. UniProtKB:Q08881, Cys-594, MOD:00765." [IEDB_epitope:932736, PRO:DNx]


organism-gene



PR:Q19726

non-specific protein-tyrosine kinase (worm)

ITK (worm)


"A tyrosine-protein kinase ITK/TSK that is encoded in the genome of worm." [PRO:WCB]


sequence



PR:000002238

tyrosine-protein kinase ITK/TSK isoform 1

ITK/iso:1


"A tyrosine-protein kinase ITK/TSK that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q03526-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:Q03526-1

tyrosine-protein kinase ITK/TSK isoform 1 (mouse)

mITK/iso:1


"A tyrosine-protein kinase ITK/TSK isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


sequence



PR:000002239

tyrosine-protein kinase ITK/TSK isoform 2

ITK/iso:2


"A tyrosine-protein kinase ITK/TSK that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08881-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:Q08881-1

tyrosine-protein kinase ITK/TSK isoform 1 (human)

hITK/iso:1


"A tyrosine-protein kinase ITK/TSK isoform 2 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:Q5STT8

tyrosine-protein kinase ITK/TSK isoform 2 (mouse)

mITK/iso:2


"A tyrosine-protein kinase ITK/TSK isoform 2 that is encoded in the genome of mouse." [PRO:JAN]


gene



PR:000002200

cytoplasmic tyrosine-protein kinase BMX

BMX


"A TEC-type tyrosine-protein kinase that is a translation product of the human BMX gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:P51813

cytoplasmic tyrosine-protein kinase BMX (human)

hBMX


"A cytoplasmic tyrosine-protein kinase BMX that is encoded in the genome of human." [PRO:WCB, UniProtKB:P51813]


organism-sequence



PR:P51813-1

cytoplasmic tyrosine-protein kinase BMX isoform 1 (human)

hBMX/iso:1


"A cytoplasmic tyrosine-protein kinase BMX isoform 2 that is encoded in the genome of human." [PRO:JAN]


organism-gene



PR:P97504

cytoplasmic tyrosine-protein kinase BMX (mouse)

mBMX


"A cytoplasmic tyrosine-protein kinase BMX that is encoded in the genome of mouse." [OMA:P97504, PRO:DNx]


organism-sequence



PR:P97504-1

cytoplasmic tyrosine-protein kinase BMX isoform 1 (mouse)

mBMX/iso:1


"A cytoplasmic tyrosine-protein kinase BMX isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


sequence



PR:000002323

cytoplasmic tyrosine-protein kinase BMX isoform 1

BMX/iso:1


"A cytoplasmic tyrosine-protein kinase BMX that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P97504-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P97504-1

cytoplasmic tyrosine-protein kinase BMX isoform 1 (mouse)

mBMX/iso:1


"A cytoplasmic tyrosine-protein kinase BMX isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


sequence



PR:000002324

cytoplasmic tyrosine-protein kinase BMX isoform 2

BMX/iso:2


"A cytoplasmic tyrosine-protein kinase BMX that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51813-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P51813-1

cytoplasmic tyrosine-protein kinase BMX isoform 1 (human)

hBMX/iso:1


"A cytoplasmic tyrosine-protein kinase BMX isoform 2 that is encoded in the genome of human." [PRO:JAN]


gene



PR:000002240

tyrosine-protein kinase Tec

TEC


"A TEC-type tyrosine-protein kinase that is a translation product of the human TEC gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:P24604

tyrosine-protein kinase Tec (mouse)

mTEC


"A tyrosine-protein kinase Tec that is encoded in the genome of mouse." [OMA:P24604, PRO:DNx]


organism-sequence



PR:P24604-1

tyrosine-protein kinase Tec isoform 1 (mouse)

mTEC/iso:1


"A tyrosine-protein kinase Tec isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


organism-sequence



PR:P24604-2

tyrosine-protein kinase Tec isoform 2 (mouse)

mTEC/iso:2


"A tyrosine-protein kinase Tec isoform 2 that is encoded in the genome of mouse." [PRO:JAN]


organism-sequence



PR:P24604-3

tyrosine-protein kinase Tec isoform 3 (mouse)

mTEC/iso:3


"A tyrosine-protein kinase Tec isoform 3 that is encoded in the genome of mouse." [PRO:JAN]


organism-sequence



PR:P24604-4

tyrosine-protein kinase Tec isoform 4 (mouse)

mTEC/iso:4


"A tyrosine-protein kinase Tec isoform 4 that is encoded in the genome of mouse." [PRO:JAN]


organism-sequence



PR:P24604-5

tyrosine-protein kinase Tec isoform 5 (mouse)

mTEC/iso:5


"A tyrosine-protein kinase Tec isoform 5 that is encoded in the genome of mouse." [PRO:JAN]


organism-sequence



PR:P24604-6

tyrosine-protein kinase Tec isoform 6 (mouse)

mTEC/iso:6


"A tyrosine-protein kinase Tec isoform 6 that is encoded in the genome of mouse." [PRO:JAN]


organism-gene



PR:P42680

tyrosine-protein kinase Tec (human)

hTEC


"A tyrosine-protein kinase Tec that is encoded in the genome of human." [PRO:WCB, UniProtKB:P42680]


organism-sequence



PR:P42680-1

tyrosine-protein kinase Tec isoform 1 (human)

hTEC/iso:1


"A tyrosine-protein kinase Tec isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-modification



PR:000049416

tyrosine-protein kinase Tec phosphorylated 1 (human)

hTEC/Phos:1


"A tyrosine-protein kinase Tec (human) that has been post-translationally modified to include phosphotyrosine at positions 206 and 519 of the amino acid sequence represented by UniProtKB:P42680. UniProtKB:P42680, Tyr-206/Tyr-519, MOD:00048." [PRO:DNx, Reactome:R-HSA-3448741]


organism-modification



PR:000049417

tyrosine-protein kinase Tec phosphorylated 2 (human)

hTEC/Phos:2


"A tyrosine-protein kinase Tec (human) that has been phosphorylated on the residue at the position equivalent to Tyr-519 of the amino acid sequence represented by UniProtKB:P42680. UniProtKB:P42680, Tyr-519, MOD:00048." [PRO:DNx, Reactome:R-HSA-3448739]


sequence



PR:000002366

tyrosine-protein kinase Tec isoform 1

TEC/iso:1


"A tyrosine-protein kinase Tec that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24604-1 or a 1:1 ortholog thereof. Tec is a cytoplasmic protein tyrosine kinase that participates in the signalling pathways of a broad range of cytokines." [PMID:10343129, PRO:JAN]


organism-sequence



PR:P24604-1

tyrosine-protein kinase Tec isoform 1 (mouse)

mTEC/iso:1


"A tyrosine-protein kinase Tec isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


organism-sequence



PR:P42680-1

tyrosine-protein kinase Tec isoform 1 (human)

hTEC/iso:1


"A tyrosine-protein kinase Tec isoform 1 that is encoded in the genome of human." [PRO:JAN]


sequence



PR:000002367

tyrosine-protein kinase Tec isoform 2

TEC/iso:2


"A tyrosine-protein kinase Tec that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24604-2 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P24604-2

tyrosine-protein kinase Tec isoform 2 (mouse)

mTEC/iso:2


"A tyrosine-protein kinase Tec isoform 2 that is encoded in the genome of mouse." [PRO:JAN]


sequence



PR:000002368

tyrosine-protein kinase Tec isoform 3

TEC/iso:3


"A tyrosine-protein kinase Tec that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24604-3 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P24604-3

tyrosine-protein kinase Tec isoform 3 (mouse)

mTEC/iso:3


"A tyrosine-protein kinase Tec isoform 3 that is encoded in the genome of mouse." [PRO:JAN]


sequence



PR:000002369

tyrosine-protein kinase Tec isoform 4

TEC/iso:4


"A tyrosine-protein kinase Tec that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24604-4 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P24604-4

tyrosine-protein kinase Tec isoform 4 (mouse)

mTEC/iso:4


"A tyrosine-protein kinase Tec isoform 4 that is encoded in the genome of mouse." [PRO:JAN]


sequence



PR:000002370

tyrosine-protein kinase Tec isoform 5

TEC/iso:5


"A tyrosine-protein kinase Tec that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24604-5 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P24604-5

tyrosine-protein kinase Tec isoform 5 (mouse)

mTEC/iso:5


"A tyrosine-protein kinase Tec isoform 5 that is encoded in the genome of mouse." [PRO:JAN]


sequence



PR:000002371

tyrosine-protein kinase Tec isoform 6

TEC/iso:6


"A tyrosine-protein kinase Tec that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24604-6 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P24604-6

tyrosine-protein kinase Tec isoform 6 (mouse)

mTEC/iso:6


"A tyrosine-protein kinase Tec isoform 6 that is encoded in the genome of mouse." [PRO:JAN]


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TPCN2 forms found in complexes   

TPCN2 Component
Complexes
PR:000044351 hBTK/InitMet- PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:P35991 mBTK PR:000037477 TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:000037478 pTIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:000037481 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (mouse)